Qianwen Liu
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View article: Magnetic resonance‐guided split‐course hypo‐fractionated radiotherapy with concurrent chemotherapy and consolidative immunotherapy in locally advanced non–small cell lung cancer: A single arm, phase 2 study
Magnetic resonance‐guided split‐course hypo‐fractionated radiotherapy with concurrent chemotherapy and consolidative immunotherapy in locally advanced non–small cell lung cancer: A single arm, phase 2 study Open
Background To evaluate the efficacy and safety of magnetic resonance (MR)‐guided split‐course hypo‐fractionated radiotherapy (hypo‐RT) with concurrent chemotherapy followed by consolidative immunotherapy (CIT) in locally advanced non–small…
View article: A Prognostic Gene Model with Psychological Stress-related Genes Captures Immune Activation in Breast Cancer
A Prognostic Gene Model with Psychological Stress-related Genes Captures Immune Activation in Breast Cancer Open
View article: Clinical significance and minimal clinically important differences for the survival outcomes in randomized clinical trials of lung cancer
Clinical significance and minimal clinically important differences for the survival outcomes in randomized clinical trials of lung cancer Open
View article: Development and validation of a nomogram for predicting long-term survival in pN + esophageal squamous cell carcinoma treated using radical resection without neoadjuvant therapy
Development and validation of a nomogram for predicting long-term survival in pN + esophageal squamous cell carcinoma treated using radical resection without neoadjuvant therapy Open
This study developed a prognostic nomogram for pN + ESCC patients who have not undergone neoadjuvant therapy and have undergone radical resection, providing superior predictive accuracy compared to the TNM staging system and easy to use in…
View article: Pan-immune-inflammation value predicts survival of patients with oesophageal squamous cell carcinoma receiving immunotherapy and chemoradiotherapy: a pooled analysis of two phase II trials
Pan-immune-inflammation value predicts survival of patients with oesophageal squamous cell carcinoma receiving immunotherapy and chemoradiotherapy: a pooled analysis of two phase II trials Open
High PIV zenith during CRT strongly predicts poorer survival outcomes in patients with ESCC treated with combined immunotherapy and CRT. These peaks are associated with higher MLD, reduced interferon α response, interferon γ response and i…
View article: Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial
Safety, pharmacokinetic, pharmacodynamic, and efficacy properties of orally administered APG-2449 in patients with advanced ALK and ROS1 non-small-cell lung cancer: a multicentre, open-label, single-arm phase 1 trial Open
Ascentage Pharma Group Corp Ltd. (Hong Kong).
View article: Consolidative nivolumab versus observation in unresectable stage III non-small cell lung cancer patients following neoadjuvant nivolumab plus chemotherapy and concurrent chemoradiotherapy (CA209-7AL): a randomized clinical trial
Consolidative nivolumab versus observation in unresectable stage III non-small cell lung cancer patients following neoadjuvant nivolumab plus chemotherapy and concurrent chemoradiotherapy (CA209-7AL): a randomized clinical trial Open
View article: A preliminary analysis of integrating thymosin α1 into concurrent chemoradiotherapy and consolidative immunotherapy in unresectable locally advanced non-small cell lung cancer
A preliminary analysis of integrating thymosin α1 into concurrent chemoradiotherapy and consolidative immunotherapy in unresectable locally advanced non-small cell lung cancer Open
Integrating Tα1 into CCRT and consolidative immunotherapy could have a synergistic effect in patients with LA-NSCLC. This combination may enhance survival outcomes and reduce treatment-related toxicity. Further randomized trial is warrante…
View article: Transcriptome analysis of peach seedlings ( <i>Prunus davidiana</i> ) experiencing drought stress
Transcriptome analysis of peach seedlings ( <i>Prunus davidiana</i> ) experiencing drought stress Open
The frequency of drought is expected to rise in many parts of the world with increasing climate change. Despite being an economically valuable plant species, the molecular mechanisms regulating the responses of peach ( Prunus davidiana ) t…
View article: MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance
MicroRNA-mediated autophagy regulation in thyroid cancer drug resistance Open
Thyroid cancer, particularly papillary thyroid cancer (PTC), represents the most prevalent endocrine malignancy. Despite advancements in therapeutic strategies, drug resistance significantly hampers clinical outcomes. Autophagy, an evoluti…
View article: Interpretable machine learning models for predicting childhood myopia from school-based screening data
Interpretable machine learning models for predicting childhood myopia from school-based screening data Open
View article: Long-Term Morphological and Hemodynamic Changes of Intercostal Artery Patch Following Thoracoabdominal Aortic Aneurysm Repair
Long-Term Morphological and Hemodynamic Changes of Intercostal Artery Patch Following Thoracoabdominal Aortic Aneurysm Repair Open
View article: Pulsed Strategy Steers the Structural Evolution of Cu Metal–Organic Framework for CO<sub>2</sub> Reduction to Methane
Pulsed Strategy Steers the Structural Evolution of Cu Metal–Organic Framework for CO<sub>2</sub> Reduction to Methane Open
The electrochemical CO 2 reduction reaction (CO 2 RR) to produce hydrocarbon fuels, such as methane (CH 4 ), offers a promising pathway to address the dual challenges of climate change and energy shortage. Although copper‐based metal‐organ…
View article: A Threat Flow Classification Method Based on Feature Fusion and Weighted Attention
A Threat Flow Classification Method Based on Feature Fusion and Weighted Attention Open
With the rapid development of the Internet, the increasing network traffic has brought a greater burden to network management. At the same time, abnormal traffic attacks on network equipment pose significant security risks. Classifying net…
View article: Phase 1b/2 study of ADG106, a 4-1BB/CD137 agonist, in combination with toripalimab in patients with advanced solid tumors
Phase 1b/2 study of ADG106, a 4-1BB/CD137 agonist, in combination with toripalimab in patients with advanced solid tumors Open
View article: Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study
Causal associations between atrial fibrillation and esophageal cancer: a two-sample Mendelian randomization study Open
This two-sample MR analysis suggested that AF was causally associated with an increased risk of EC.
View article: Nomograms for predicting the prognosis in multiple primary esophageal squamous cell carcinoma
Nomograms for predicting the prognosis in multiple primary esophageal squamous cell carcinoma Open
These nomograms could effectively predict the 1-year, 3-year and 5-year survival outcomes of patients with SMPESCs. Furthermore, adjuvant therapy has the potential to improve OS in patients with lymph node metastasis.
View article: Social support, self-efficacy, self-esteem, and self-management behaviors among people living with HIV/AIDS in China: a structural equation modeling analysis
Social support, self-efficacy, self-esteem, and self-management behaviors among people living with HIV/AIDS in China: a structural equation modeling analysis Open
View article: Development and application of a serious adverse events risk model for concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma
Development and application of a serious adverse events risk model for concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma Open
The objective of this study was to construct a concise prediction model for serious adverse events (SAEs) in order to assess the likelihood of SAE occurrence among hospitalized patients undergoing concurrent chemoradiotherapy. An electroni…
View article: Early change of plasma Epstein-Barr virus DNA load and the viral lytic genome level could positively predict clinical outcome in recurrent or metastatic nasopharyngeal carcinoma receiving anti-programmed cell death 1 monotherapy
Early change of plasma Epstein-Barr virus DNA load and the viral lytic genome level could positively predict clinical outcome in recurrent or metastatic nasopharyngeal carcinoma receiving anti-programmed cell death 1 monotherapy Open
View article: Single‐cell <scp>RNA</scp> sequencing elucidated the landscape of breast cancer brain metastases and identified <scp>ILF2</scp> as a potential therapeutic target
Single‐cell <span>RNA</span> sequencing elucidated the landscape of breast cancer brain metastases and identified <span>ILF2</span> as a potential therapeutic target Open
Distant metastasis remains the primary cause of morbidity in patients with breast cancer. Hence, the development of more efficacious strategies and the exploration of potential targets for patients with metastatic breast cancer are urgentl…
View article: Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells
Multidrug resistance transporters P-gp and BCRP limit the efficacy of ATR inhibitor ceralasertib in cancer cells Open
The therapeutic effect of chemotherapy and targeted therapy are known to be limited by drug resistance. Substantial evidence has shown that ATP-binding cassette (ABC) transporters P-gp and BCRP are significant contributors to multidrug res…
View article: CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1–CXCR2 induced NETs
CD276 regulates the immune escape of esophageal squamous cell carcinoma through CXCL1–CXCR2 induced NETs Open
Background CD276 (B7-H3), a pivotal immune checkpoint, facilitates tumorigenicity, invasiveness, and metastasis by escaping immune surveillance in a variety of tumors; however, the underlying mechanisms facilitating immune escape in esopha…
View article: Integrating bulk and single-cell sequencing data to construct a Scissor+ dendritic cells prognostic model for predicting prognosis and immune responses in ESCC
Integrating bulk and single-cell sequencing data to construct a Scissor+ dendritic cells prognostic model for predicting prognosis and immune responses in ESCC Open
View article: Risk assessment of extra-uterine involvement and prognosis in young type I endometrial carcinoma with high or moderate differentiation and less than 1/2 myometrial invasion
Risk assessment of extra-uterine involvement and prognosis in young type I endometrial carcinoma with high or moderate differentiation and less than 1/2 myometrial invasion Open
Surgery with adnexal preservation and without systematic lymphadenectomy could be employed for the patients who are high differentiation with less than 1/2 myometrial invasion or moderate differentiation without myometrial invasion, but no…
View article: Event Temporal Relation Extraction based on Retrieval-Augmented on LLMs
Event Temporal Relation Extraction based on Retrieval-Augmented on LLMs Open
Event temporal relation (TempRel) is a primary subject of the event relation extraction task. However, the inherent ambiguity of TempRel increases the difficulty of the task. With the rise of prompt engineering, it is important to design e…
View article: Whether surgical procedure can improve the prognosis of endometrial cancer arising in adenomyosis (EC-AIA)? A systematic review and meta-analysis
Whether surgical procedure can improve the prognosis of endometrial cancer arising in adenomyosis (EC-AIA)? A systematic review and meta-analysis Open
Purpose: Endometrial cancer arising in adenomyosis (EC-AIA) is frequently detected accidentally following a general hysterectomy for adenomyosis. Whether supplemental lymphadenectomy in patients with EC-AIA can improve the survival outcome…
View article: RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma
RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma Open
View article: The power and the promise of synthetic lethality for clinical application in cancer treatment
The power and the promise of synthetic lethality for clinical application in cancer treatment Open
Synthetic lethality is a phenomenon wherein the simultaneous deficiency of two or more genes results in cell death, while the deficiency of any individual gene does not lead to cell death. In recent years, synthetic lethality has emerged a…
View article: Evolution of genome and immunogenome in esophageal squamous cell carcinomas driven by neoadjuvant chemoradiotherapy
Evolution of genome and immunogenome in esophageal squamous cell carcinomas driven by neoadjuvant chemoradiotherapy Open
Background Neoadjuvant chemoradiotherapy (NCRT) followed by surgery is a standard treatment for locally advanced esophageal squamous cell carcinomas (ESCCs). However, evolution of genome and immunogenome in ESCCs driven by NCRT remain inco…