Xishi Liu
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View article: Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium
Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium Open
STUDY QUESTION Do all ectopic endometrial lesions (endometriosis and adenomyosis) universally have activated estrogen signaling? SUMMARY ANSWER Estrogen signaling diminishes concordantly with increased fibrosis in ectopic endometrium, with…
View article: Dienogest Treatment of Symptomatic Adenomyosis: An In-Depth Meta-Analysis
Dienogest Treatment of Symptomatic Adenomyosis: An In-Depth Meta-Analysis Open
eview question / Objective PICOS Framework: Population: Women with symptomatic adenomyosis, particularly those experiencing dysmenorrhea.Intervention: Treatment with dienogest
View article: Reproductive outcomes in women with uterine fibroids: High-intensity focused ultrasound vs. myomectomy
Reproductive outcomes in women with uterine fibroids: High-intensity focused ultrasound vs. myomectomy Open
keywords, and their combinations were used to search for all possible publications: high-intensity focused ultrasound ablation, HIFU, laparoscopy, l a p a ro s c o p e s , l a p a ro s c o p i c , l a p a ro t o m y, laparotomies, abdomina…
View article: Shorter Anogenital Distance in Women with Ovarian Endometriomas and Adenomyosis, but Not Uterine Leiomyomas
Shorter Anogenital Distance in Women with Ovarian Endometriomas and Adenomyosis, but Not Uterine Leiomyomas Open
We investigated whether anogenital distance (AGD) is associated with adenomyosis, endometriosis and uterine leiomyomas (UL, also called uterine fibroids). We recruited 81 women with UL, 105 with ovarian endometrioma (OE), 116 with adenomyo…
View article: Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target
Aberrant expression of histone deacetylase 8 in endometriosis and its potential as a therapeutic target Open
Purpose To screen Zn 2+ ‐dependent histone deacetylase (HDAC) 1‐11 in endometriotic cells and then evaluated the HDACs identified from the screening in ovarian endometrioma (OE) and deep endometriotic (DE) lesions, and to evaluate the ther…
View article: Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis
Corroborating evidence for aberrant expression of histone deacetylase 8 in endometriosis Open
Purpose The aim of this study was to evaluate the dynamic change in staining of Class I HDACs and Hdac6 in lesions harvested serially from different time points in mice with induced endometriosis. In addition, the effect of Hdac8 activatio…
View article: Interleukin-33 Derived from Endometriotic Lesions Promotes Fibrogenesis through Inducing the Production of Profibrotic Cytokines by Regulatory T Cells
Interleukin-33 Derived from Endometriotic Lesions Promotes Fibrogenesis through Inducing the Production of Profibrotic Cytokines by Regulatory T Cells Open
In endometriosis, it has been widely believed that the local immunological milieu is Th2-skewed. Regulatory T cells (Tregs) promote fibrogenesis of endometriosis through the transforming growth factor β1 (TGF-β1) and platelet-derived growt…
View article: Neonatal feeding of an estrogen receptor β agonist induces external adenomyosis-like lesions in ICR mouse
Neonatal feeding of an estrogen receptor β agonist induces external adenomyosis-like lesions in ICR mouse Open
Objective: Despite the fact that adenomyosis is a fairly common gynecological disorder, its pathogenesis remains elusive. Several theories on the pathogenesis of adenomyosis have been proposed, but none of them has been proven experimental…
View article: Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis
Activation of α7 nicotinic acetylcholine receptor retards the development of endometriosis Open
Background Women with endometriosis have been shown to have a reduced vagal tone as compared with controls and vagotomy promoted while vagus nerve stimulation (VNS) decelerated the progression of endometriosis in mice. Extensive research a…
View article: Perioperative Suppression of Schwann Cell Dedifferentiation Reduces the Risk of Adenomyosis Resulting from Endometrial–Myometrial Interface Disruption in Mice
Perioperative Suppression of Schwann Cell Dedifferentiation Reduces the Risk of Adenomyosis Resulting from Endometrial–Myometrial Interface Disruption in Mice Open
We have recently demonstrated that endometrial–myometrial interface (EMI) disruption (EMID) can cause adenomyosis in mice, providing experimental evidence for the well-documented epidemiological finding that iatrogenic uterine procedures i…
View article: Unveiling the Pathogenesis of Adenomyosis through Animal Models
Unveiling the Pathogenesis of Adenomyosis through Animal Models Open
Background: Adenomyosis is a common gynecological disorder traditionally viewed as “elusive”. Several excellent review papers have been published fairly recently on its pathogenesis, and several theories have been proposed. However, the fa…
View article: How does the extent of fibrosis in adenomyosis lesions contribute to heavy menstrual bleeding?
How does the extent of fibrosis in adenomyosis lesions contribute to heavy menstrual bleeding? Open
Purpose To investigate how the extent of fibrosis in adenomyosis lesions contributes to heavy menstrual bleeding (HMB). Methods We recruited 57 women with histologically confirmed adenomyosis, 29 of whom reported moderate/heavy bleeding (M…
View article: Tetramethylpyrazine Stalls Lesional Progression via Inducing Senescence in Mouse with Induced Deep Endometriosis
Tetramethylpyrazine Stalls Lesional Progression via Inducing Senescence in Mouse with Induced Deep Endometriosis Open
So far, the pressing need for the development of non-hormonal therapeutics for endometriosis has been unfulfilled. In light of the evidence that platelets play important roles in the development of endometriosis and that tetramethylpyrazin…
View article: Changing prostaglandin E2 (PGE<sub>2</sub>) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE<sub>2</sub> receptor EP2 and EP4
Changing prostaglandin E2 (PGE<sub>2</sub>) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE<sub>2</sub> receptor EP2 and EP4 Open
Purpose We investigated the change, if any, in prostaglandin E2 (PGE 2 ) signaling in endometriotic lesions of different developmental stages in mouse. In addition, we evaluated the effect of treatment of mice with induced deep endometrios…
View article: Higher fibrotic content of endometriotic lesions is associated with diminished prostaglandin E2 signaling
Higher fibrotic content of endometriotic lesions is associated with diminished prostaglandin E2 signaling Open
Purpose While the prevailing view holds that the prostaglandin E2 (PGE 2 ) signaling plays a vital role in endometriosis, PGE 2 also is known to be anti‐fibrotic. We investigated the immunostaining of COX‐2, EP2, and EP4, along with fibrot…
View article: The relevance of plasma R-spondin 1 and Slit2 as predictive biomarkers in cervical cancer chemotherapy and radiotherapy
The relevance of plasma R-spondin 1 and Slit2 as predictive biomarkers in cervical cancer chemotherapy and radiotherapy Open
The levels of Rspo1 and Slit2 correlate positively to the tolerance of the patients. In contrast, the levels of Rspo1 and Slit2 showed a negative correlation to the morbidity score of the patients undergoing CT and/or RT. Thus, Rspo1 and S…
View article: Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis
Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis Open
Background Accumulating data indicate that sensory nerve derived neuropeptides such as substance P and calcitonin gene related-protein (CGRP) can accelerate the progression of endometriosis via their respective receptors, so can agonists t…
View article: Reduced vagal tone in women with endometriosis and auricular vagus nerve stimulation as a potential therapeutic approach
Reduced vagal tone in women with endometriosis and auricular vagus nerve stimulation as a potential therapeutic approach Open
View article: Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis
Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis Open
Endometriosis is a hormonal disease, as well as a chronic inflammatory disease. While various immune cells are documented to be involved in endometriosis, there is a wanton lack of a bigger picture on how these cells are coordinated to wor…
View article: Mesothelial Cells Participate in Endometriosis Fibrogenesis Through Platelet-Induced Mesothelial-Mesenchymal Transition
Mesothelial Cells Participate in Endometriosis Fibrogenesis Through Platelet-Induced Mesothelial-Mesenchymal Transition Open
Context While fibrosis in endometriosis has recently loomed prominently, the sources of myofibroblasts, the principal effector cell in fibrotic diseases, remain largely obscure. Mesothelial cells (MCs) can be converted into myofibroblasts …
View article: Response to Letter to the Editor from Liu et al: “Evidence in Support for the Progressive Nature of Ovarian Endometriomas”
Response to Letter to the Editor from Liu et al: “Evidence in Support for the Progressive Nature of Ovarian Endometriomas” Open
View article: Early maternal separation accelerates the progression of endometriosis in adult mice
Early maternal separation accelerates the progression of endometriosis in adult mice Open
View article: Evidence in Support for the Progressive Nature of Ovarian Endometriomas
Evidence in Support for the Progressive Nature of Ovarian Endometriomas Open
Context Whether endometriosis is a progressive disease is a highly contentious issue. While progression is reported to be unlikely in asymptomatic deep endometriosis, progression in symptomatic deep endometriosis has recently been reported…
View article: Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells
Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells Open
View article: Platelets drive fibrogenesis through induction of endothelial-mesemchymal transition (EndoMT) in endometriosis
Platelets drive fibrogenesis through induction of endothelial-mesemchymal transition (EndoMT) in endometriosis Open
View article: Concurrent Learning Curves of 3-Dimensional and Robotic-Assisted Laparoscopic Radical Hysterectomy for Early-Stage Cervical Cancer Using 2-Dimensional Laparoscopic Radical Hysterectomy as a Benchmark: A Single Surgeon’s Experience
Concurrent Learning Curves of 3-Dimensional and Robotic-Assisted Laparoscopic Radical Hysterectomy for Early-Stage Cervical Cancer Using 2-Dimensional Laparoscopic Radical Hysterectomy as a Benchmark: A Single Surgeon’s Experience Open
BACKGROUND For early-stage cervical cancers, radical hysterectomy (RH) with pelvic lymphadenectomy has been the standard care. This study compared the learning curves and intra-, peri-, and post-operative outcomes for 3-dimensional laparos…
View article: Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis
Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis Open
View article: Activated Platelets Induce Hypoxia-Inducible Factor-1α Expression Likely through Transforming Growth Factor-β1 in Human Endometrial Stromal Cells
Activated Platelets Induce Hypoxia-Inducible Factor-1α Expression Likely through Transforming Growth Factor-β1 in Human Endometrial Stromal Cells Open
Objective: Endometriosis is a common gynecological disease with an enigmatic pathogenesis. Recent studies suggest that the behavior of normal endometrial stromal cells can dramatically change under hypoxic conditions, which effectively tur…
View article: Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis
Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis Open
Endometriotic lesions are known to be hyperinnervated, especially in lesions of deep endometriosis (DE), which are frequently in close proximity to various nerve plexuses. DE lesions typically have higher fibromuscular content than that of…
View article: Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis
Sensory nerve-derived neuropeptides accelerate the development and fibrogenesis of endometriosis Open
This research was supported by Grants 81471434 (SWG), 81530040 (SWG), 81771553 (SWG), 81671436 (XSL) and 81871144 (XSL) from the National Natural Science Foundation of China and an Excellence in Centres of Clinical Medicine grant (2017ZZ01…