Li Han
YOU?
Author Swipe
View article: Prebiotic Effect of Oxidized Hydroxypropyl Starch via In Vitro and In Vivo
Prebiotic Effect of Oxidized Hydroxypropyl Starch via In Vitro and In Vivo Open
Most studies on resistant starch are limited to its effect on blood glucose; there are few studies on the prebiotic effects of resistant starch on the gut. In this experiment, through in vivo metabolism verification and in vitro simulated …
View article: Bovine Neutrophil β-Defensin-5 Provides Protection against Multidrug-Resistant Klebsiella pneumoniae via Regulating Pulmonary Inflammatory Response and Metabolic Response
Bovine Neutrophil β-Defensin-5 Provides Protection against Multidrug-Resistant Klebsiella pneumoniae via Regulating Pulmonary Inflammatory Response and Metabolic Response Open
Klebsiella pneumoniae (K. pneumoniae), a kind of zoonotic bacteria, is among the most common antibiotic-resistant pathogens, and it causes nosocomial infections that pose a threat to public health. In this study, the roles of synthetic bov…
View article: Ningxiang Pig-Derived Microbiota Affects the Growth Performance, Gut Microbiota, and Serum Metabolome of Nursery Pigs
Ningxiang Pig-Derived Microbiota Affects the Growth Performance, Gut Microbiota, and Serum Metabolome of Nursery Pigs Open
The gut microbiota is crucial for maintaining the host’s intestinal homeostasis and metabolism. This study investigated the effects of fecal microbiota transplantation (FMT) from Ningxiang pigs on the growth performance, fecal microbiota, …
View article: Development of a TaqMan probe-based multiplex real-time PCR for the simultaneous detection of four clinically important filamentous fungi
Development of a TaqMan probe-based multiplex real-time PCR for the simultaneous detection of four clinically important filamentous fungi Open
Filamentous fungi present significant health hazards to immunocompromised individuals globally; however, the prompt and precise identification of them during infection remains challenging. In this study, a TaqMan probe-based multiplex real…
View article: PD-1 Inhibitors Combined with Antiangiogenic Therapy with or Without Transarterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Propensity Matching Analysis
PD-1 Inhibitors Combined with Antiangiogenic Therapy with or Without Transarterial Chemoembolization in the Treatment of Hepatocellular Carcinoma: A Propensity Matching Analysis Open
Antiangiogenic therapy combined with PD-1 inhibitors combined with TACE has significant survival benefits for HCC patients.
View article: Screening and Validation of Internal Reference Genes for Quantitative Real-Time PCR Analysis of Leaf Color Mutants in Dendrobium officinale
Screening and Validation of Internal Reference Genes for Quantitative Real-Time PCR Analysis of Leaf Color Mutants in Dendrobium officinale Open
Leaf color mutants (LCMs) are important resources for studying diverse metabolic processes such as chloroplast biogenesis and differentiation, pigments’ biosynthesis and accumulation, and photosynthesis. However, in Dendrobium officinale, …
View article: Salicylic acid inhibits rice endocytic protein trafficking mediated by <scp>OsPIN3t</scp> and clathrin to affect root growth
Salicylic acid inhibits rice endocytic protein trafficking mediated by <span>OsPIN3t</span> and clathrin to affect root growth Open
SUMMARY Salicylic acid (SA) plays important roles in different aspects of plant development, including root growth, where auxin is also a major player by means of its asymmetric distribution. However, the mechanism underlying the effect of…
View article: Roles of Host Phospholipase D during Aspergillus fumigatus Infection in Mice
Roles of Host Phospholipase D during Aspergillus fumigatus Infection in Mice Open
Objective: Aspergillus fumigatus infection in the lungs is accompanied by the recruitment of innate immune cells, phagocytosis, and the release of inflammatory factors. Phospholipase D (PLD) is a key regulator of cell migration and phagocy…
View article: Identification of RNA-based cell-type markers for the stem cell manufacture system with a statistical scoring function
Identification of RNA-based cell-type markers for the stem cell manufacture system with a statistical scoring function Open
Cell-type biomarkers are useful in stem cell manufacture to monitor cell purification, cell quantity, and quality. However, the study on cell-type markers, specifically for stem cell manufacture, is limited. The emerging questions are whic…
View article: Improving three-dimensional human pluripotent cell culture efficiency via surface molecule coating
Improving three-dimensional human pluripotent cell culture efficiency via surface molecule coating Open
Human pluripotent stem cells (hPSCs) are ideal “raw materials” for making various human cell types for regenerative medicine and are needed in large numbers. 3D suspension culturing (e.g., stirred-tank bioreactor or STR), which suspends an…
View article: Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency
Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency Open
The protective effect of estrogens against cortical bone loss is mediated via direct actions on mesenchymal cells, but functional evidence for the mediators of these effects has only recently begun to emerge. We report that the matrix meta…
View article: Effect of transcutaneous electrical acupoint stimulation on bone loss for patients with foot and ankle fracture: a pragmatic randomized controlled trial.
Effect of transcutaneous electrical acupoint stimulation on bone loss for patients with foot and ankle fracture: a pragmatic randomized controlled trial. Open
TEAS treatment may confer additional benefits for bone loss in patients with immobilization after surgical fixation of ankle and foot fractures. Since this was a pilot study, the efficacy of TEAS requires further evaluation through full-sc…
View article: Novel Pathogenic Mutation of PNPLA1 Identified in Autosomal Recessive Congenital Ichthyosis: A Case Report
Novel Pathogenic Mutation of PNPLA1 Identified in Autosomal Recessive Congenital Ichthyosis: A Case Report Open
Autosomal recessive congenital ichthyosis (ARCI) is characterized by being born as collodion babies, hyperkeratosis, and skin scaling. We described a collodion baby at birth with mild ectropion, eclabium, and syndactyly. Whole exome sequen…
View article: Engineered human brown adipocyte microtissues improved glucose and insulin homeostasis in high fat diet-induced obese and diabetic mice
Engineered human brown adipocyte microtissues improved glucose and insulin homeostasis in high fat diet-induced obese and diabetic mice Open
A large population of people is affected by obesity (OB) and its associated type 2 diabetes mellitus(T2DM). There are currently no safe and long-lasting anti-OB/T2DM therapies. Clinical data and preclinical transplantation studies show tha…
View article: Long Terminal Repeat Retrotransposon <i>Afut4</i> Promotes Azole Resistance of Aspergillus fumigatus by Enhancing the Expression of <i>sac1</i> Gene
Long Terminal Repeat Retrotransposon <i>Afut4</i> Promotes Azole Resistance of Aspergillus fumigatus by Enhancing the Expression of <i>sac1</i> Gene Open
Aspergillus fumigatus causes a series of invasive diseases, including the high-mortality invasive aspergillosis, and has been a serious global health threat because of its increased resistance to the first-line clinical triazoles. We analy…
View article: Complement receptor 3 mediates<i>Aspergillus fumigatus</i>internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK
Complement receptor 3 mediates<i>Aspergillus fumigatus</i>internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK Open
Complement receptor 3 (CD11b/CD18) is an important receptor that mediates adhesion, phagocytosis and chemotaxis in various immunocytes. The conidia of the medically-important pathogenic fungus, Aspergillus fumigatus can be internalized int…
View article: Essential Role of CRIM1 on Endometrial Receptivity in Goat
Essential Role of CRIM1 on Endometrial Receptivity in Goat Open
In domestic ruminants, endometrial receptivity is related to successful pregnancy and economic efficiency. Despite several molecules having been reported in the past regarding endometrial receptivity regulation, much regarding the mechanis…
View article: Structural insights into the activation of human calcium-sensing receptor
Structural insights into the activation of human calcium-sensing receptor Open
Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that maintains Ca 2+ homeostasis in serum. Here, we present the cryo-electron microscopy structures of the CaSR in the inactive and active states. Complemented with prev…
View article: Elevation of the unfolded protein response increases RANKL expression
Elevation of the unfolded protein response increases RANKL expression Open
Increased production of the osteoclastogenic cytokine RANKL is a common feature of pathologic bone loss, but the underlying cause of this increase is poorly understood. The unfolded protein response (UPR) is activated in response to accumu…
View article: Discovery and identification of medium‐chain fatty acid responsive promoters in <i>Saccharomyces cerevisiae</i>
Discovery and identification of medium‐chain fatty acid responsive promoters in <i>Saccharomyces cerevisiae</i> Open
Medium‐chain fatty acids (MCFAs) and their derivatives are important chemicals that can be used in lubricants, detergents, and cosmetics. MCFAs can be produced in several microbes, although production is not high. Dynamic regulation by syn…
View article: Change in soil microbial quotient along an altitudinal gradient in an alpine-gorge region
Change in soil microbial quotient along an altitudinal gradient in an alpine-gorge region Open
We conducted a 3-year in-situ soil core incubation experiment in dry valley shrub (A1), a valley-mountain ecotone forest (A2), a subalpine coniferous forest (A3), an alpine coniferous forest (A4) and an alpine meadow (A5) across a 2431-m a…
View article: High Azole Resistance in <i>Aspergillus fumigatus</i> Isolates from Strawberry Fields, China, 2018
High Azole Resistance in <i>Aspergillus fumigatus</i> Isolates from Strawberry Fields, China, 2018 Open
In 2018, we conducted a cross-sectional study to investigate azole resistance in environmental Aspergillus fumigatus isolates obtained from different agricultural fields in China. Using 63 soil cores, we cultured for azole-resistant A. fum…
View article: Comparison of Two Typing Methods for Characterization of Azole Resistance in Aspergillus fumigatus from Potting Soil Samples in a Chinese Hospital
Comparison of Two Typing Methods for Characterization of Azole Resistance in Aspergillus fumigatus from Potting Soil Samples in a Chinese Hospital Open
To understand the characterizations of azole resistance in Aspergillus fumigatus from potting soil samples in the hospital, a total of 58 samples were collected. Among 106 A. fumigatus samples obtained, 5 isolates from 4 soil samples locat…
View article: Stimulation of Piezo1 by mechanical signals promotes bone anabolism
Stimulation of Piezo1 by mechanical signals promotes bone anabolism Open
Mechanical loading, such as caused by exercise, stimulates bone formation by osteoblasts and increases bone strength, but the mechanisms are poorly understood. Osteocytes reside in bone matrix, sense changes in mechanical load, and produce…