Liuhanghang Cheng
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View article: Achieving ideal surgical outcomes by identifying the dominant supratrochlear artery for forehead flap harvesting: A comparative study
Achieving ideal surgical outcomes by identifying the dominant supratrochlear artery for forehead flap harvesting: A comparative study Open
Background: Despite being considered the golden standard for nasal reconstruction for decades, there has been a lack of detailed investigation into the hemodynamic differences between bilateral supratrochlear vessels during forehead flap p…
View article: The cyclization of human salivary Histatin 1 via click chemistry for skin wound healing
The cyclization of human salivary Histatin 1 via click chemistry for skin wound healing Open
View article: A Modified Hyaluronic Acid–Based Dissolving Microneedle Loaded With Daphnetin Improved the Treatment of Psoriasis
A Modified Hyaluronic Acid–Based Dissolving Microneedle Loaded With Daphnetin Improved the Treatment of Psoriasis Open
Psoriasis is a common chronic immune-inflammatory disease. Challenges exist in the present treatment of psoriasis, such as difficulties in transdermal drug administration and severe side effects. We hope to achieve a better therapeutic out…
View article: Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast
Histatin 1 enhanced the speed and quality of wound healing through regulating the behaviour of fibroblast Open
Objectives Histatin 1(Hst 1) has been proved to promote wound healing. However, there was no specific study on the regulation made by Hst 1 of fibroblasts in the process of wound healing. This research comprehensively studied the regulatio…
View article: Co-administration of platelet-rich plasma and small intestinal submucosa is more beneficial than their individual use in promoting acute skin wound healing
Co-administration of platelet-rich plasma and small intestinal submucosa is more beneficial than their individual use in promoting acute skin wound healing Open
Background Acute skin wounds may compromise the skin barrier, posing a risk of infection. Small intestinal submucosa (SIS) is widely used to treat acute and chronic wounds. However, the efficacy of SIS to accelerate wound healing still nee…
View article: Hematopoietic stem cells can differentiate into pericytes and myofibroblast in wound healing, not bone Mesenchymal stem cells
Hematopoietic stem cells can differentiate into pericytes and myofibroblast in wound healing, not bone Mesenchymal stem cells Open
Background Hematopoietic stem cells(HSCs) and mesenchymal stem cells(MSCs) can participate in wound healing. However, very few studies had shown HSCs and MSCs could arrive to the wound and differentiate into tissues. In this study, we inte…
View article: Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste
Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste Open
A rapid wound healing is beneficial for not only recovering esthetics but also reducing pain, complications and healthcare burdens. For such a purpose, continuous efforts have been taken to develop viable dressing material. Acellular derma…
View article: Investigating the effect of age on platelet ultrastructure using transmission electron microscopy
Investigating the effect of age on platelet ultrastructure using transmission electron microscopy Open
In the present study, the age‐ and sex‐related differences in platelet ultrastructure were investigated using transmission electron microscopy (TEM). A total of 15 healthy volunteers were grouped according to age, with 5 people in each of …
View article: Issue Information
Issue Information Open
TK"), who passed away on 20 Feb 2019 at the age of 88, was a pillar of the wound healing community.His role as a trauma surgeon and his curiosity as an investigator emerged over 5 decades ago.He became Director of the Wound Healing Laborat…
View article: DNA hypermethylation of Fgf16 and Tbx22 associated with cleft palate during palatal fusion
DNA hypermethylation of Fgf16 and Tbx22 associated with cleft palate during palatal fusion Open
Taken together, these results suggest that hypermethylation of Fgf16 and Tbx22 is associated with decreased gene expression, which might be responsible for developmental failure of palatal fusion, eventually resulting in the formation of C…
View article: Position-dependent correlation between TBX22 exon 5 methylation and palatal shelf fusion in the development of cleft palate
Position-dependent correlation between TBX22 exon 5 methylation and palatal shelf fusion in the development of cleft palate Open
DNA methylation is essential for spatiotemporally-regulated gene expression in embryonic development. TBX22 (Chr X: 107667964-107688978) functioning as a transcriptional repressor affects DNA binding, sumoylation, and transcriptional repre…
View article: DNA hypermethylation of Fgf16 and Tbx22 associated with cleft palate during palatal fusion
DNA hypermethylation of Fgf16 and Tbx22 associated with cleft palate during palatal fusion Open
Objective: Cleft palate (CP) is a congenital birth defect caused by the failure of palatal fusion. Little is known about the potential role of DNA methylation in the pathogenesis of CP. This study aimed to explore the potential role of DNA…
View article: Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment
Redirecting differentiation of mammary progenitor cells by 3D bioprinted sweat gland microenvironment Open
Background Mammary progenitor cells (MPCs) maintain their reproductive potency through life, and their specific microenvironments exert a deterministic control over these cells. MPCs provides one kind of ideal tools for studying engineered…
View article: Differential Innervation of Secretory Coils and Ducts in Human Eccrine Sweat Glands
Differential Innervation of Secretory Coils and Ducts in Human Eccrine Sweat Glands Open
Sweat secretion is mainly controlled by autonomic nerves whereas sweat reabsorption is less affected by nerve activity.
View article: Genome-Wide DNA Methylation Analysis During Palatal Fusion Reveals the Potential Mechanism of Enhancer Methylation Regulating Epithelial Mesenchyme Transformation
Genome-Wide DNA Methylation Analysis During Palatal Fusion Reveals the Potential Mechanism of Enhancer Methylation Regulating Epithelial Mesenchyme Transformation Open
Epithelial mesenchyme transformation (EMT) of the medial edge epithelium (MEE) is the crucial process during palatal fusion. This work is aimed to elucidate the enhancer regulatory mechanism by genome-wide DNA methylation analysis of EMT d…