Longfei Wu
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View article: Causal associations between diet and thromboembolism: A 2-sample Mendelian randomization study
Causal associations between diet and thromboembolism: A 2-sample Mendelian randomization study Open
Studies have revealed links between diet and cardiovascular conditions such as venous thromboembolism (VTE). The potential causal relationship between dietary habits and VTE remains ambiguous. This study aimed to assess the causal associat…
View article: Association of insulin resistance indices with outcomes after endovascular treatment in acute basilar artery occlusion
Association of insulin resistance indices with outcomes after endovascular treatment in acute basilar artery occlusion Open
Among BAO patients who underwent EVT, the TyG index could strongly predict unfavorable functional recovery and mortality, whereas the METS-IR was mainly associated with mortality. These findings indicate that TyG may help in refining risk …
View article: Early antiplatelet therapy was associated with reduced neurological deterioration in stroke patients treated with intravenous thrombolysis
Early antiplatelet therapy was associated with reduced neurological deterioration in stroke patients treated with intravenous thrombolysis Open
BACKGROUND: Patients with acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) are at high risk of early neurological deterioration (END) due to increased platelet activation. OBJECTIVES: The objective of the study was t…
View article: Programmed Cell Death of Chondrocytes, Synovial Cells, Osteoclasts, and Subchondral Bone Cells in Osteoarthritis
Programmed Cell Death of Chondrocytes, Synovial Cells, Osteoclasts, and Subchondral Bone Cells in Osteoarthritis Open
Osteoarthritis (OA) is a common and debilitating chronic disease characterized by severe inflammation and progressive damage to adjacent tissues and cartilage. Traditional risk factors such as obesity, gender, and aging have long been reco…
View article: Acidic tumor microenvironment–modulated nanoparticle potentiates gastric cancer photoimmunotherapy
Acidic tumor microenvironment–modulated nanoparticle potentiates gastric cancer photoimmunotherapy Open
Our results revealed that the combination of FX-11@PEG-Ce6-based photodynamic therapy and immunotherapy could achieve a synergistic antitumor effect with excellent biosafety, presenting great therapeutic potential for enhanced photoimmunot…
View article: Lactylation‐Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib
Lactylation‐Driven HECTD2 Limits the Response of Hepatocellular Carcinoma to Lenvatinib Open
Drug resistance remains a major hurdle for the therapeutic efficacy of lenvatinib in hepatocellular carcinoma (HCC). However, the underlying mechanisms remain largely undetermined. Unbiased proteomic screening is performed to identify the …
View article: Role and Mechanism of Mitochondrial Ribosomal Proteins in Septic Myocardial Injury
Role and Mechanism of Mitochondrial Ribosomal Proteins in Septic Myocardial Injury Open
The findings suggest that both MRPS16 and MRPL47 can mitigate mitochondrial injury by attenuating mitochondrial biosynthesis dysfunction, energy metabolism disorders, and Ca2+ disturbances caused by septic myocardial injury. This ultimatel…
View article: Licochalcone a: A promising antiparasitic drug against giardiasis
Licochalcone a: A promising antiparasitic drug against giardiasis Open
Giardiasis, caused by Giardia duodenalis, is a prevalent and significant zoonotic disease. While nitroimidazole drugs are primarily used to treat giardiasis, the urgent need for the development and formulation of new drugs has arisen due t…
View article: Clostridium butyricum, a future star in sepsis treatment
Clostridium butyricum, a future star in sepsis treatment Open
Sepsis is a systemic inflammatory response syndrome of multiorgan failure caused by dysregulation of the host response to infection and is a major cause of death in critically ill patients. In recent years, with the continuous development …
View article: Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg
Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg Open
Sepsis-induced myocardial injury has become a major threat to patient health and safety. Intestinal microbiota imbalance plays a crucial role in sepsis regulation. Using 16srRNA technology, we explored how intestinal colonization of Clostr…
View article: Role of plasma suPAR, sTNFR1, and sTNFR2 levels in risk stratification and outcome prediction of complicated acute kidney injury in elderly patients with coronavirus disease 2019
Role of plasma suPAR, sTNFR1, and sTNFR2 levels in risk stratification and outcome prediction of complicated acute kidney injury in elderly patients with coronavirus disease 2019 Open
Elderly patients had increased risks of complicated AKI. Indicators such as suPAR, sTNFR1, and sTNFR2 can assist in assessing the risk in patients with COVID-19 complicated AKI, with suPAR demonstrating the highest prognostic efficacy as a…
View article: Mild hypothermia therapy attenuates early BBB leakage in acute ischemic stroke
Mild hypothermia therapy attenuates early BBB leakage in acute ischemic stroke Open
Reperfusion therapy inevitably leads to brain–blood barrier (BBB) disruption and promotes damage despite its benefits for acute ischaemic stroke (AIS). An effective brain cytoprotective treatment is still needed as an adjunct to reperfusio…
View article: Night shift work was associated with functional outcomes in acute ischemic stroke patients treated with endovascular thrombectomy
Night shift work was associated with functional outcomes in acute ischemic stroke patients treated with endovascular thrombectomy Open
Our findings suggest that late night shift work is significantly associated with unfavorable outcomes in patients with AIS after EVT.
View article: Hypothermic neuroprotection by targeted cold autologous blood transfusion in a non-human primate stroke model
Hypothermic neuroprotection by targeted cold autologous blood transfusion in a non-human primate stroke model Open
Over decades, nearly all attempts to translate the benefits of therapeutic hypothermia in stroke models of lower-order species to stroke patients have failed. Potentially overlooked reasons may be biological gaps between different species …
View article: Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia
Dual-sized hollow particle incorporated fibroin thermal insulating coatings on catheter for cerebral therapeutic hypothermia Open
Selective endovascular hypothermia has been used to provide cooling-induced cerebral neuroprotection, but current catheters do not support thermally-insulated transfer of cold infusate, which results in an increased exit temperature, cause…
View article: The optimum anticoagulation time after endovascular thrombectomy for atrial fibrillation-related large vessel occlusion stroke: a real-world study
The optimum anticoagulation time after endovascular thrombectomy for atrial fibrillation-related large vessel occlusion stroke: a real-world study Open
Objectives To investigate the relationship between the initiation time of anticoagulation after endovascular treatment (EVT) and the outcomes in atrial fibrillation (AF)-related acute ischemic stroke (AIS) patients. Methods In this prospec…
View article: Association of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with outcomes in stroke patients achieving successful recanalization by endovascular thrombectomy
Association of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with outcomes in stroke patients achieving successful recanalization by endovascular thrombectomy Open
Objective Serum inflammatory biomarkers play crucial roles in the development of acute ischemic stroke (AIS). In this study, we explored the association between inflammatory biomarkers including platelet-to-lymphocyte ratio (PLR), neutroph…
View article: Ischemic post-conditioning in acute ischemic stroke thrombectomy: A phase-I duration escalation study
Ischemic post-conditioning in acute ischemic stroke thrombectomy: A phase-I duration escalation study Open
Background Previous experimental studies have found that ischemic post-conditioning exhibits neuroprotective effects by alleviating ischemia-reperfusion injury in an acute ischemic stroke model, and its efficacy is thought to be related to…
View article: Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion
Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion Open
Among patients with stroke due to basilar-artery occlusion who presented 6 to 24 hours after symptom onset, thrombectomy led to a higher percentage with good functional status at 90 days than medical therapy but was associated with procedu…
View article: Safety and efficacy of different tirofiban administration routes on acute ischemic stroke patients with successful recanalization: A propensity score matching analysis
Safety and efficacy of different tirofiban administration routes on acute ischemic stroke patients with successful recanalization: A propensity score matching analysis Open
Objective This study aimed to explore the effect of different administration routes of a low dose of tirofiban on acute ischemic stroke (AIS) patients with successful recanalization after endovascular treatment (EVT). Methods This is a coh…
View article: Association between the time of day at stroke onset and functional outcome of acute ischemic stroke patients treated with endovascular therapy
Association between the time of day at stroke onset and functional outcome of acute ischemic stroke patients treated with endovascular therapy Open
To investigate the association between time-of-day of stroke onset and functional outcome in patients with acute ischemic stroke(AIS) treated with endovascular thrombectomy(EVT). AIS patients treated with EVT between January 2013 and Decem…
View article: Elevated pulsatility index is associated with poor functional outcome in stroke patients treated with thrombectomy: A retrospective cohort study
Elevated pulsatility index is associated with poor functional outcome in stroke patients treated with thrombectomy: A retrospective cohort study Open
Aims To evaluate pulsatility index (PI) in patients with acute ischemic stroke (AIS) who underwent endovascular thrombectomy (EVT). Methods Patients were retrospectively recruited if their stroke were secondary to middle cerebral artery (M…
View article: The intra‐arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy
The intra‐arterial selective cooling infusion system: A mathematical temperature analysis and in vitro experiments for acute ischemic stroke therapy Open
Introduction The neuroprotection of acute ischemic stroke patients can be achieved by intra‐arterial selective cooling infusion using cold saline, which can decrease brain temperature without influencing the body core temperature. This app…
View article: Dysregulation of Principal Circulating miRNAs in Non-human Primates Following Ischemic Stroke
Dysregulation of Principal Circulating miRNAs in Non-human Primates Following Ischemic Stroke Open
Despite the recent interest in plasma microRNA (miRNA) biomarkers in acute ischemic stroke patients, there is limited knowledge about the miRNAs directly related to stroke itself due to the multiple complications in patients, which has hin…