Lin Deng
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View article: Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets
Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets Open
Lipid droplets (LDs) are evolutionarily conserved organelles essential for cellular metabolism. They form and grow at the endoplasmic reticulum (ER), requiring lipid transfer between these compartments, yet the underlying molecular mechani…
View article: Finding a Diagnosis in Obscure Gastrointestinal Bleeding: A Case of Small Bowel Neuroendocrine Tumor
Finding a Diagnosis in Obscure Gastrointestinal Bleeding: A Case of Small Bowel Neuroendocrine Tumor Open
Small bowel or mid-gut gastrointestinal (GI) bleeding has been historically difficult to diagnose and is believed to be the main culprit of what was once termed obscure GI bleeding. Small bowel bleeding is difficult to evaluate due to its …
View article: RsMYB8-RsMYB73 module positively regulates parthenocarpic fruitsetting via elevating <i>RsGA3ox9</i> expression in seedless chestnut rose (<i>Rosa sterilis</i>)
RsMYB8-RsMYB73 module positively regulates parthenocarpic fruitsetting via elevating <i>RsGA3ox9</i> expression in seedless chestnut rose (<i>Rosa sterilis</i>) Open
Fruit growth and development are generally initiated following successful pollination and fertilization. Seedless chestnut rose (Rosa sterilis), an elite promising fruit tree for both edible and medicinal purposes due to the extremely high…
View article: Decoding the interplay between m <sup>6</sup> A modification and stress granule stability by live-cell imaging
Decoding the interplay between m <sup>6</sup> A modification and stress granule stability by live-cell imaging Open
N 6 -methyladenosine (m 6 A)–modified mRNAs and their cytoplasmic reader YTHDFs are colocalized with stress granules (SGs) under stress conditions, but the interplay between m 6 A modification and SG stability remains unclear. Here, we pre…
View article: Liaohe Oilfield Reservoir Parameters Inversion Based on Composite Dislocation Model Utilizing Two-Dimensional Time-Series InSAR Observations
Liaohe Oilfield Reservoir Parameters Inversion Based on Composite Dislocation Model Utilizing Two-Dimensional Time-Series InSAR Observations Open
To address the industry’s demand for sustainable oilfield development and safe production, it is crucial to enhance the scientific rigor and accuracy of monitoring ground stability and reservoir parameter inversion. For the above purposes,…
View article: Regeneration of Propriospinal Axons in Rat Transected Spinal Cord Injury through a Growth-Promoting Pathway Constructed by Schwann Cells Overexpressing GDNF
Regeneration of Propriospinal Axons in Rat Transected Spinal Cord Injury through a Growth-Promoting Pathway Constructed by Schwann Cells Overexpressing GDNF Open
Unsuccessful axonal regeneration in transected spinal cord injury (SCI) is mainly attributed to shortage of growth factors, inhibitory glial scar, and low intrinsic regenerating capacity of severely injured neurons. Previously, we construc…
View article: Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex
Biogenesis of Rab14-positive endosome buds at Golgi–endosome contacts by the RhoBTB3–SHIP164–Vps26B complex Open
Early endosomes (EEs) are crucial in cargo sorting within vesicular trafficking. While cargoes destined for degradation are retained in EEs and eventually transported to lysosomes, recycled cargoes for the plasma membrane (PM) or the Golgi…
View article: An association analysis of lipidome and transcriptome highlights the involvement of MmGDPD1 in regulating low phosphorus tolerance in Malus mandshurica
An association analysis of lipidome and transcriptome highlights the involvement of MmGDPD1 in regulating low phosphorus tolerance in Malus mandshurica Open
Phosphorus (Pi) plays a crucial role in the growth and development of plants. Membrane lipid regulation is one of the main mechanisms underlying plant adaptation to Pi deficiency. Previously, the high tolerance to low-Pi stress was justifi…
View article: Detection of Frog Virus 3 by Integrating RPA-CRISPR/Cas12a-SPM with Deep Learning
Detection of Frog Virus 3 by Integrating RPA-CRISPR/Cas12a-SPM with Deep Learning Open
A fast, easy-to-implement, highly sensitive, and point-of-care (POC) detection system for frog virus 3 (FV3) is proposed. Combining recombinase polymerase amplification (RPA) and CRISPR/Cas12a, a limit of detection (LoD) of 100 aM (60.2 co…
View article: A distinct class of pan-cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association study
A distinct class of pan-cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association study Open
Alternative polyadenylation (APA) plays an important role in cancer initiation and progression; however, current genome- and transcriptome-wide association studies (GWAS and TWAS, respectively) mostly ignore APA when identifying putative c…
View article: Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sites
Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sites Open
ER tubules form and maintain membrane contact sites (MCSs) with late endosomes/lysosomes (LE/lys). The molecular composition and cellular functions of these MCSs are poorly understood. Here, we find that Tex2, an SMP domain-containing lipi…
View article: A Possible Role of VPS13B in the Formation of Golgi-Lipid Droplet Contacts Associating with the ER
A Possible Role of VPS13B in the Formation of Golgi-Lipid Droplet Contacts Associating with the ER Open
While the physical interactions between the Golgi apparatus (Golgi) and lipid droplets (LDs) have been suggested through system-level imaging, the Golgi-LD membrane contact sites (MCSs) remain largely uncharacterized. Here, we show evidenc…
View article: Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection
Angiotensin-Converting Enzyme 2-Based Biosensing Modalities and Devices for Coronavirus Detection Open
Rapid and cost-effective diagnostic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are a critical and valuable weapon for the coronavirus disease 2019 (COVID-19) pandemic response. SARS-CoV-2 invasion is primarily m…
View article: A complex containing RhoBTB3-SHIP164-Vps26B promotes the biogenesis of early endosome buds at Golgi-endosome contacts
A complex containing RhoBTB3-SHIP164-Vps26B promotes the biogenesis of early endosome buds at Golgi-endosome contacts Open
Early endosomes (EEs) are central hubs for cargo sorting in vesicular trafficking. Cargoes destined for degradation retain in EEs that are eventually delivered to lysosomes, while recycled cargo destined for the plasma membrane (PM) or to …
View article: Detection of Frog virus 3 via the system integrating RPA-CRISPR/Cas12a-SPM with deep learning
Detection of Frog virus 3 via the system integrating RPA-CRISPR/Cas12a-SPM with deep learning Open
Frog virus 3 (FV3, genera Ranavirus , family Iridoviridae ), a double-stranded DNA virus, results in irreparable damage to biodiversity and significant economic losses to aquaculture. Although the existing FV3 detection methods are of high…
View article: Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sites
Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sites Open
ER tubules form and maintain membrane contact sites (MCSs) with late endosomes/lysosomes (LE/lys). The molecular composition and cellular functions of these MCSs are poorly understood. Here we find that Tex2, an SMP domain-containing lipid…
View article: Cross−Talk between Transcriptome Analysis and Physiological Characterization Identifies the Genes in Response to the Low Phosphorus Stress in Malus mandshurica
Cross−Talk between Transcriptome Analysis and Physiological Characterization Identifies the Genes in Response to the Low Phosphorus Stress in Malus mandshurica Open
Phosphorus (Pi) is a macronutrient essential for plant growth, development, and reproduction. However, there is not an efficient available amount of Pi that can be absorbed by plants in the soil. Previously, an elite line, MSDZ 109, select…
View article: Editorial: DNA Replication Stress and Cell Fate
Editorial: DNA Replication Stress and Cell Fate Open
International audience
View article: Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System
Amplification-free detection of viral RNA by super resolution imaging-based CRISPR/Cas13a System Open
RNA detection is crucial for biological research and clinical diagnosis. The current methods include both direct and amplification-based RNA detection. These methods require complicated procedures, suffering from low sensitivity, slow turn…
View article: CCDC 1876002: Experimental Crystal Structure Determination
CCDC 1876002: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1589374: Experimental Crystal Structure Determination
CCDC 1589374: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …