Liv Eidsmo
YOU?
Author Swipe
View article: Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis
Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis Open
Importance Smoking and obesity are associated with risk of hidradenitis suppurativa, and both are considered important environmental risk factors. However, a causal relationship remains unproven. Objective To primarily investigate the rela…
View article: Scalable Acid-Aided Lysis of Skin Samples Improves Proteome Coverage
Scalable Acid-Aided Lysis of Skin Samples Improves Proteome Coverage Open
Liquid chromatography-mass spectrometry is an evolving tool for comprehensive proteomic analyses across tissues. Despite the widespread use of liquid chromatography-mass spectrometry in dermatology, full-thickness human skin remains challe…
Researcher Reflections—Inspiring Paths in Academia Open
The journey of early‐career researchers (ECRs) in immunology is marked by many challenges but also exciting prospects. Here we bring a snapshot of the recent ECR workshop organized by the Young European Federation of Immunology Societies (…
Secukinumab and Dead Sea Climatotherapy Impact Resolved Psoriasis Skin Differently Potentially Affecting Disease Memory Open
Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients, through distinct mechanisms. However, recurrence in the same areas after treatments suggests the existence of a molecular scar. We aimed to compare the mo…
View article: Investigation of plaque psoriasis relapse after secukinumab withdrawal in patients from two phase III studies
Investigation of plaque psoriasis relapse after secukinumab withdrawal in patients from two phase III studies Open
Background Secukinumab is effective against a range of psoriatic manifestations. Investigating psoriasis (PsO) relapse following secukinumab discontinuation could provide insights into long-term PsO remission. Objectives To examine PsO rel…
View article: The cellular microenvironment regulates CX3CR1 expression on CD8 <sup>+</sup> T cells and the maintenance of CX3CR1 <sup>+</sup> CD8 <sup>+</sup> T cells
The cellular microenvironment regulates CX3CR1 expression on CD8 <sup>+</sup> T cells and the maintenance of CX3CR1 <sup>+</sup> CD8 <sup>+</sup> T cells Open
Expression levels of the chemokine receptor CX3CR1 serve as high‐resolution marker delineating functionally distinct antigen‐experienced T‐cell states. The factors that influence CX3CR1 expression in T cells are, however, incompletely unde…
Method for high‐plex analysis of immune cells in human skin using the GeoMx system Open
Specific T cell populations in the skin have been demonstrated as important disease drivers in several dermatoses. Due to the unique skin architecture, these cells are not grouped together in structures but dispersedly spread out throughou…
Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor Open
Cutaneous T-cell lymphomas (CTCL) are characterized by focal infiltration of malignant T cell clones in solitary skin lesions. Many CTCL patients experience an indolent disease, but some progress to advanced disease with high fatality. We …
View article: Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation
Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation Open
T cells differentiate into functionally distinct states upon antigen encounter. These states are delineated by different cell surface markers for murine and human T cells, which hamper cross-species translation of T cell properties. We aim…
Secukinumab demonstrates superiority over narrow‐band ultraviolet B phototherapy in new‐onset moderate to severe plaque psoriasis patients: Week 52 results from the <span>STEPIn</span> study Open
Background Biologic treatments have been studied mainly in patients with a long‐term history of psoriasis and previous treatment failures. Objectives The purpose of this primary analysis of the STEPIn study is to determine whether early in…
View article: T cells in resolved allergic contact dermatitis steer tissue inflammation and <scp>MMP</scp>‐12–driven tissue modulation
T cells in resolved allergic contact dermatitis steer tissue inflammation and <span>MMP</span>‐12–driven tissue modulation Open
Tissue resident memory T cells contribute to localized immunity in barrier tissues such as the skin1 but are also implicated in local relapse of focal inflammatory skin diseases, including allergic contact dermatitis (ACD) and psoriasis.2-…
A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen Open
Significance The nine-member transglutaminase protein family includes five known autoantigens. Because of the frequent roles of transglutaminases in autoimmunity, we decided to explore whether the remaining members might also constitute au…
Vancomycin‐Loaded Microneedle Arrays against Methicillin‐Resistant <i>Staphylococcus Aureus</i> Skin Infections Open
Skin and soft tissue infections (SSTIs) caused by methicillin‐resistant Staphylococcus aureus (MRSA) are a major healthcare burden, often treated with intravenous injection of the glycopeptide antibiotic vancomycin (VAN). However, low loca…
View article: Single-cell analysis reveals MHCII expressing keratinocytes in pressure ulcers with worse healing outcomes
Single-cell analysis reveals MHCII expressing keratinocytes in pressure ulcers with worse healing outcomes Open
Pressure ulcer (PU) is a chronic wound often seen in spinal cord injury patients and other bed-bound individuals, particularly in the elderly population. Despite its association with high mortality, the pathophysiology of PU remains poorly…
Intestinal helminth infection transforms the CD4+ T cell composition of the skin Open
Intestinal helminth parasites can alter immune responses to vaccines, other infections, allergens and autoantigens, indicating effects on host immune responses in distal barrier tissues. We herein show that C57BL/6 mice infected with the s…
Long-term Outcomes and Prognosis in New-Onset Psoriasis Open
The findings of this cohort study suggest that combinations of clinical characteristics at onset and activating genes in the IL-23 pathway are significantly associated with the clinical course of psoriasis, whereas joint pain and periphera…
Cellular scars and local crosstalk in relapsing psoriasis: an example of a skin sticking disease Open
Psoriasis is an inflammatory disease that arises in genetically predisposed individuals. Chronic skin lesions that contain activated immune cells can persist for years. Systemic inhibition of TNF, IL‐17 and IL‐23 cytokines has revolutioniz…
View article: Secukinumab treatment in new‐onset psoriasis: aiming to understand the potential for disease modification – rationale and design of the randomized, multicenter <scp>STEPI</scp>n study
Secukinumab treatment in new‐onset psoriasis: aiming to understand the potential for disease modification – rationale and design of the randomized, multicenter <span>STEPI</span>n study Open
Background To date, biological treatments have been assessed in subjects with a long‐term history of psoriasis and previous failures to systemic and topical therapies. In rheumatoid arthritis and other immune‐mediated inflammatory diseases…
Human Langerhans Cells with Pro-inflammatory Features Relocate within Psoriasis Lesions Open
Psoriasis is a common skin disease that presents with well-demarcated patches of inflammation. Recurrent disease in fixed areas of the skin indicates a localized disease memory that is preserved in resolved lesions. In line with such conce…