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View article: Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat (Diabetes Metab J 2025;49:990-1005)
Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat (Diabetes Metab J 2025;49:990-1005) Open
View article: The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation
The neuroprotective effect of cannabidiol is enhanced by resveratrol and alpha-lipoic acid in social isolation Open
Introduction Post-traumatic stress disorder (PTSD) is a chronic psychiatric condition characterized by persistent cognitive and affective disturbances following exposure to severe trauma. In rodents, prolonged post-weaning social isolation…
View article: Hydroxyl carboxylic acid receptor-2 (HCAR2) as a potential target in neurometabolic diseases
Hydroxyl carboxylic acid receptor-2 (HCAR2) as a potential target in neurometabolic diseases Open
Hydroxycarboxylic acid receptor 2 (HCAR2) is a G-protein-coupled receptor initially identified for its role in lipid metabolism. Beyond its classical metabolic functions, HCAR2 plays a pivotal role in chronic inflammatory diseases, neurome…
View article: Modulatory activity of N-palmitoyl-D-glucosamine in bridging gut dysbiosis and pain mechanisms
Modulatory activity of N-palmitoyl-D-glucosamine in bridging gut dysbiosis and pain mechanisms Open
Gut dysbiosis, characterized by an imbalance in the composition and function of microbiota, has emerged as a critical factor in the regulation of pain transmission and behavior through the gut–brain axis. When dysbiosis occurs, these regul…
View article: Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat
Effects of CXCR1/2 Blockade with Ladarixin on Streptozotocin-Induced Type 1 Diabetes Mellitus and Peripheral Neuropathy and Retinopathy in Rat Open
Background: The CXC motif chemokine ligand 8 (CXCL8)-CXC motif chemokine receptor 1/2 (CXCR1/2) axis has been implicated in type 1 diabetes mellitus (T1DM). Its actions on non-immune cells may also contribute to T1DM-associated complicatio…
View article: Acute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats
Acute kappa opioid receptor blocking disrupts the pro-cognitive effect of cannabidiol in neuropathic rats Open
Cannabidiol has been shown to ameliorate neuropathic pain and its affective components. Previous studies highlighted the pharmacological interaction between the CBD and opioid system, particularly the MOR, but the understanding of the inte…
View article: Combining Acmella oleracea and Boswellia serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia
Combining Acmella oleracea and Boswellia serrata extracts: a novel pharmacological approach in inflammatory vestibulodynia Open
Vulvodynia is a chronic pain condition that affects the vulvar area, often resulting in significant discomfort and a reduced quality of life. Current treatments for vulvodynia are limited, and there is a need for more effective therapeutic…
View article: Identification of Cannabidiolic and Cannabigerolic Acids as <scp>MTDL AChE</scp>, <scp>BuChE,</scp> and <scp>BACE</scp>‐1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies
Identification of Cannabidiolic and Cannabigerolic Acids as <span>MTDL AChE</span>, <span>BuChE,</span> and <span>BACE</span>‐1 Inhibitors Against Alzheimer's Disease by In Silico, In Vitro, and In Vivo Studies Open
Cannabidiolic (CBDA) and cannabigerolic (CBGA) acids are naturally occurring compounds from Cannabis sativa plant, previously identified by us as dual PPARα/γ agonists. Since the development of multitarget‐directed ligands (MTDL) represent…
View article: Corrigendum: Long-term efficacy and reduced side-effects of buprenorphine in patients with moderate and severe chronic pain
Corrigendum: Long-term efficacy and reduced side-effects of buprenorphine in patients with moderate and severe chronic pain Open
[This corrects the article DOI: 10.3389/fphar.2024.1454601.].
View article: Lighting the shades of hidden pain: a role for spinal cord neurons and microglia in vestibulodynia
Lighting the shades of hidden pain: a role for spinal cord neurons and microglia in vestibulodynia Open
View article: Long-term efficacy and reduced side-effects of buprenorphine in patients with moderate and severe chronic pain
Long-term efficacy and reduced side-effects of buprenorphine in patients with moderate and severe chronic pain Open
Background Chronic pain significantly impacts quality of life and poses substantial public health challenges. Buprenorphine, a synthetic analog of thebaine, is recognized for its potential in managing moderate to severe chronic pain with f…
View article: Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo
Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo Open
Endoplasmic reticulum (ER) remodeling is vital for cellular organization. ER-phagy, a selective autophagy targeting ER, plays an important role in maintaining ER morphology and function. The FAM134 protein family, including FAM134A, FAM134…
View article: A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs Open
We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain. Optical activation of systemic JF-NP-26, a caged, normally inactive, negative allosteric modulator (…
View article: Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI
Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI Open
Background Despite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular determinants on long-term consequences, such as dementia and Alzheimer’s disease (AD). Methods Here…
View article: Author response: A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
Author response: A ‘double-edged’ role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs Open
View article: PEA-OXA restores cognitive impairments associated with vitamin D deficiency-dependent alterations of the gut microbiota
PEA-OXA restores cognitive impairments associated with vitamin D deficiency-dependent alterations of the gut microbiota Open
There is a growing evidence suggesting the association of vitamin D deficiency (VDD) and cognitive impairment. In this study we evaluated the possible involvement of gut microbiota in the cognitive impairments mediated by VDD and investiga…
View article: A “double-edged” role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs
A “double-edged” role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs Open
Knowing the site of drug action is important to optimize effectiveness and address any side effects. We used light-sensitive drugs to identify the brain region-specific role of mGlu5 metabotropic glutamate receptors in the control of pain.…
View article: Combination Drug Therapy for the Management of Chronic Neuropathic Pain
Combination Drug Therapy for the Management of Chronic Neuropathic Pain Open
Chronic neuropathic pain (NP) is an increasingly prevalent disease and leading cause of disability which is challenging to treat. Several distinct classes of drugs are currently used for the treatment of chronic NP, but each drug targets o…
View article: Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of SnakeVenom, on Formalin-induced Inflammation in Mice
Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of SnakeVenom, on Formalin-induced Inflammation in Mice Open
Background: Integrins, important extracellular matrix (ECM) receptor proteins, are affected by inflammation and can participate in the maintenance of many painful conditions. Although they are ubiquitous and changeable across all cell type…
View article: LOCUS COERULEUS MEDIATES THE PHARMACOLOGICAL EFFECTS OF 2-PENTADECYL-2-OXAZOLINE IN A MOUSE MODEL OF NEUROPATHIC PAIN: THE DUALISM OF LOCUS COERULEUS NEURONS ACTIVITY
LOCUS COERULEUS MEDIATES THE PHARMACOLOGICAL EFFECTS OF 2-PENTADECYL-2-OXAZOLINE IN A MOUSE MODEL OF NEUROPATHIC PAIN: THE DUALISM OF LOCUS COERULEUS NEURONS ACTIVITY Open
View article: Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP
Scopolamine-Induced Memory Impairment in Mice: Effects of PEA-OXA on Memory Retrieval and Hippocampal LTP Open
Transient global amnesia, both persistent and transient, is a very common neuropsychiatric syndrome. Among animal models for amnesia and testing new drugs, the scopolamine test is the most widely used for transient global amnesia (TGA). Th…
View article: Mediator complex in neurological disease
Mediator complex in neurological disease Open
Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and ischemic), and inherent neurodegenerative diseases cause acquired disability in humans, representing a leading cause of death worldwide. The Mediator compl…
View article: Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC)
Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC) Open
View article: <i>In Silico</i>-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists
<i>In Silico</i>-Guided Rational Drug Design and Synthesis of Novel 4-(Thiophen-2-yl)butanamides as Potent and Selective TRPV1 Agonists Open
We describe an in silico-guided rational drug design and the synthesis of the suggested ligands, aimed at improving the TRPV1-ligand binding properties and the potency of N-(4-hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl) butana…
View article: Ketoprofen, lysine and gabapentin co-crystal magnifies synergistic efficacy and tolerability of the constituent drugs: Pre-clinical evidences towards an innovative therapeutic approach for neuroinflammatory pain
Ketoprofen, lysine and gabapentin co-crystal magnifies synergistic efficacy and tolerability of the constituent drugs: Pre-clinical evidences towards an innovative therapeutic approach for neuroinflammatory pain Open
Chronic pain is an enormous public health concern, and its treatment is still an unmet medical need. Starting from data highlighting the promising effects of some nonsteroidal anti-inflammatory drugs in combination with gabapentin in pain …
View article: The semisynthetic cannabinoid Hexahydrocannabinol (HHC)
The semisynthetic cannabinoid Hexahydrocannabinol (HHC) Open
Cannabis is a double-faced plant with uncountable therapeutic properties, on one side, and controversial psychotropic activities, on the other side, modulated by CB1 endocannabinoid receptors. Δ 9 -Tetrahydrocannabinol (Δ 9 -THC) has been …
View article: Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1)
Potential role of the hydroxyl carboxylic acid receptor type 2 (HCAR2) in microglia pathophysiology: A possible cross-talk with C-X-C chemokine receptor 1 (CXCR1) Open
Following insults or injury, microglia cells are activated contributing to the cytotoxic response or by promoting an immune-mediated damage resolution. Microglia cells express HCA2R, a hydroxy carboxylic acid (HCA) receptor, which has been…
View article: 2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic receptor back into play
2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic receptor back into play Open
The 2-pentadecyl-2-oxazoline (PEA-OXA) is a natural compound with protective action in neuro-inflammation. We have previously shown that PEA-OXA behaves as an α2 adrenergic receptor (α2AR) antagonist and a putative protean agonist on hista…
View article: Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol
Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol Open
Neuroinflammation is an emerging therapeutic target in chronic degenerative and autoimmune diseases, such as osteoarthritis (OA) and rheumatoid arthritis. Mast cells (MCs) play a key role in the homeostasis of joints and the activation of …
View article: Bayesian Network Analysis for Prediction of Unplanned Hospital Readmissions of Cancer Patients with Breakthrough Cancer Pain and Complex Care Needs
Bayesian Network Analysis for Prediction of Unplanned Hospital Readmissions of Cancer Patients with Breakthrough Cancer Pain and Complex Care Needs Open
Background: Unplanned hospital readmissions (HRAs) are very common in cancer patients. These events can potentially impair the patients’ health-related quality of life and increase cancer care costs. In this study, data-driven prediction m…