Liwu Fu
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View article: KSQ‐4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1‐Mediated Multidrug Resistant Cancers
KSQ‐4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1‐Mediated Multidrug Resistant Cancers Open
Multidrug resistance (MDR) remarkably hinders the success of clinical chemotherapy in carcinomas. The ATP‐binding cassette (ABC) transporter as ABCB1, ABCG2, and ABCC1 are most crucial to drive MDR. Regrettably, no MDR modulators have been…
View article: Clinical applications of circulating tumor cells in metastasis and therapy
Clinical applications of circulating tumor cells in metastasis and therapy Open
Circulating tumor cells (CTCs), which serve as an early indicator of tumors in peripheral blood, are closely associated with unfavorable prognoses in individuals with cancer. Gaining a thorough understanding of the heterogeneity and specif…
View article: Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy
Tumor-associated macrophages remodel the suppressive tumor immune microenvironment and targeted therapy for immunotherapy Open
Despite the significant advances in the development of immune checkpoint inhibitors (ICI), primary and acquired ICI resistance remains the primary impediment to effective cancer immunotherapy. Residing in the tumor microenvironment (TME), …
View article: Cardiotoxicity of small-molecule kinase inhibitors in cancer therapy
Cardiotoxicity of small-molecule kinase inhibitors in cancer therapy Open
Cancer is one of the leading causes of death worldwide. Recent advances in precision oncology have enabled many specific cancer patient populations to respond well and achieve longer survival with small-molecule kinase inhibitors, which ha…
View article: Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion
Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion Open
The crosstalk between immunity and cancer in the regulation of tumor growth is considered a hallmark of cancer. Antitumor immunity refers to the innate and adaptive immune responses that regulate cancer development and proliferation. Tumor…
View article: Correction: Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance
Correction: Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance Open
View article: Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance
Intra-tumoral sphingobacterium multivorum promotes triple-negative breast cancer progression by suppressing tumor immunosurveillance Open
View article: Resistance to antibody–drug conjugates: A review
Resistance to antibody–drug conjugates: A review Open
Antibody-drug conjugates (ADCs) are antitumor drugs composed of monoclonal antibodies and cytotoxic payload covalently coupled by a linker. Currently, 15 ADCs have been clinically approved worldwide. More than 100 clinical trials at differ…
View article: Kinematics modeling and analysis of large parabolic cylindrical deployable antenna support mechanism
Kinematics modeling and analysis of large parabolic cylindrical deployable antenna support mechanism Open
A high deployment ratio, large aperture, lightweight design, and high precision are the trends in the development of future deployable antennas. To meet the mission requirements of spaceborne antennas, a large parabolic cylindrical deploya…
View article: PBA2, a novel inhibitor of the β-catenin/CBP pathway, eradicates chronic myeloid leukemia including BCR-ABL T315I mutation
PBA2, a novel inhibitor of the β-catenin/CBP pathway, eradicates chronic myeloid leukemia including BCR-ABL T315I mutation Open
View article: BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo Open
Background Multidrug resistance (MDR) limits successful cancer chemotherapy. P-glycoprotein (P-gp), BCRP and MRP1 are the key triggers of MDR. Unfortunately, no MDR modulator was approved by FDA to date. Here, we will investigate the effec…
View article: Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis Open
View article: Protein tyrosine phosphatase PTPH1 potentiates receptor tyrosine kinase HER2 oncogenesis via a PDZ-coupled and phosphorylation-driven scaffold
Protein tyrosine phosphatase PTPH1 potentiates receptor tyrosine kinase HER2 oncogenesis via a PDZ-coupled and phosphorylation-driven scaffold Open
Cancer cell overexpresses numerus proteins, however, how these up-regulated proteins, especially those enzymatically opposite kinases and phosphatases, act together to promote oncogenesis is unknown. Here, we reported that protein tyrosine…
View article: Small-molecule agents for cancer immunotherapy
Small-molecule agents for cancer immunotherapy Open
View article: CM082 Enhances the Efficacy of Chemotherapeutic Drugs by Inhibiting the Drug Efflux Function of ABCG2
CM082 Enhances the Efficacy of Chemotherapeutic Drugs by Inhibiting the Drug Efflux Function of ABCG2 Open
[This corrects the article DOI: 10.1016/j.omto.2019.12.007.].
View article: The strategies to cure cancer patients by eradicating cancer stem-like cells
The strategies to cure cancer patients by eradicating cancer stem-like cells Open
Cancer stem-like cells (CSCs), a subpopulation of cancer cells, possess remarkable capability in proliferation, self-renewal, and differentiation. Their presence is recognized as a crucial factor contributing to tumor progression and metas…
View article: A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal
A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block “eat-me” signal Open
Immune checkpoint inhibitors (ICIs) have induced durable clinical responses in a subset of patients with colorectal cancer (CRC). However, the dis-satisfactory response rate and the lack of appropriate biomarkers for selecting suitable pat…
View article: Supplemental table S3 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors
Supplemental table S3 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors Open
Ibrutinib does not significantly sensitizes ABCG2-overexpressing cells to mitoxantrone.
View article: Data from Osimertinib (AZD9291) Enhanced the Efficacy of Chemotherapeutic Agents in ABCB1- and ABCG2-Overexpressing Cells <i>In Vitro, In Vivo</i>, and <i>Ex Vivo</i>
Data from Osimertinib (AZD9291) Enhanced the Efficacy of Chemotherapeutic Agents in ABCB1- and ABCG2-Overexpressing Cells <i>In Vitro, In Vivo</i>, and <i>Ex Vivo</i> Open
The overexpression of ATP-binding cassette (ABC) transporters has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. In our study, we investigated whether osimertinib (AZD9291), a third-generation …
View article: Supplementary Figure Legends from Osimertinib (AZD9291) Enhanced the Efficacy of Chemotherapeutic Agents in ABCB1- and ABCG2-Overexpressing Cells <i>In Vitro, In Vivo</i>, and <i>Ex Vivo</i>
Supplementary Figure Legends from Osimertinib (AZD9291) Enhanced the Efficacy of Chemotherapeutic Agents in ABCB1- and ABCG2-Overexpressing Cells <i>In Vitro, In Vivo</i>, and <i>Ex Vivo</i> Open
Figure Legend for Supplementary Figure 1
View article: Supplemental Figures 1-7 from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2
Supplemental Figures 1-7 from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2 Open
Figure S1. 14-3-3σ contributes to IR resistance. Figure S2. 14-3-3σ contributes to IR resistance in H1299 cells. Figure S3. 14-3-3σ modulates IR-induced γ-H2AX in H1299 cells. Figure S4. 14-3-3σ promotes NHEJ but not HR repair of DSBs…
View article: Supplemental table S1 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors
Supplemental table S1 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors Open
Ibrutinib significantly sensitizes ABCB1-overexpressing cells to vincristine and colchicine.
View article: Supplemental table S2 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors
Supplemental table S2 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors Open
Ibrutinib significantly sensitizes ABCC10-overexpressing cells to vincristine.
View article: Data from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors
Data from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors Open
Paclitaxel is one of the most widely used antineoplastic drugs in the clinic. Unfortunately, the occurrence of cellular resistance has limited its efficacy and application. The ATP-binding cassette subfamily B member 1 (ABCB1/P-glycoprotei…
View article: Supplementary S1 from Osimertinib (AZD9291) Enhanced the Efficacy of Chemotherapeutic Agents in ABCB1- and ABCG2-Overexpressing Cells <i>In Vitro, In Vivo</i>, and <i>Ex Vivo</i>
Supplementary S1 from Osimertinib (AZD9291) Enhanced the Efficacy of Chemotherapeutic Agents in ABCB1- and ABCG2-Overexpressing Cells <i>In Vitro, In Vivo</i>, and <i>Ex Vivo</i> Open
Figure S1. The express type of EGFR in S1, S1-MI-80, KB and KBv200 cell lines
View article: Supplemental Figures 1-7 from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2
Supplemental Figures 1-7 from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2 Open
Figure S1. 14-3-3σ contributes to IR resistance. Figure S2. 14-3-3σ contributes to IR resistance in H1299 cells. Figure S3. 14-3-3σ modulates IR-induced γ-H2AX in H1299 cells. Figure S4. 14-3-3σ promotes NHEJ but not HR repair of DSBs…
View article: Data from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2
Data from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2 Open
14-3-3σ has been implicated in the development of chemo and radiation resistance and in poor prognosis of multiple human cancers. While it has been postulated that 14-3-3σ contributes to these resistances via inhibiting apoptosis and arres…
View article: Supplemental table S3 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors
Supplemental table S3 from The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors Open
Ibrutinib does not significantly sensitizes ABCG2-overexpressing cells to mitoxantrone.
View article: Supplemental Tables from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2
Supplemental Tables from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2 Open
Supplemental Table S1. Sequence of shRNAs and siRNAs. Supplemental Table S2. Sequences of primers for real time RT-PCR.
View article: Supplemental Tables from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2
Supplemental Tables from 14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2 Open
Supplemental Table S1. Sequence of shRNAs and siRNAs. Supplemental Table S2. Sequences of primers for real time RT-PCR.