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View article: Role of serological biomarkers in evaluating and predicting endoscopic activity in inflammatory bowel disease
Role of serological biomarkers in evaluating and predicting endoscopic activity in inflammatory bowel disease Open
BACKGROUND Diagnosis of inflammatory bowel disease and assessment of disease activity are fundamentally reliant on endoscopy. Nonetheless, it is costly and invasive, highlighting the necessity for more accessible and non-invasive biomarker…
View article: Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura
Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura Open
View article: 8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus
8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus Open
Respiratory syncytial virus (RSV), along with other prominent respiratory RNA viruses such as influenza and SARS-CoV-2, significantly contributes to the global incidence of respiratory tract infections. These pathogens induce the productio…
View article: Correlates and consequences of atrial fibrillation in a prospective study of 25 000 participants in the China Kadoorie Biobank
Correlates and consequences of atrial fibrillation in a prospective study of 25 000 participants in the China Kadoorie Biobank Open
Aims The prevalence of atrial fibrillation (AF) is positively correlated with prior cardiovascular diseases (CVD) and CVD risk factors but is lower in Chinese than Europeans despite their higher burden of CVD. We examined the prevalence an…
View article: The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases
The potential for OGG1 inhibition to be a therapeutic strategy for pulmonary diseases Open
Thus, the strategic targeting of the active site pocket of OGG1 through the application of small molecules introduces an innovative trajectory for advancing redox medicine. This approach holds particular significance in the context of pulm…
View article: Site-specific acetylation of polynucleotide kinase 3′-phosphatase regulates its distinct role in DNA repair pathways
Site-specific acetylation of polynucleotide kinase 3′-phosphatase regulates its distinct role in DNA repair pathways Open
Mammalian polynucleotide kinase 3′-phosphatase (PNKP), a DNA end-processing enzyme with 3′-phosphatase and 5′-kinase activities, is involved in multiple DNA repair pathways, including base excision (BER), single-strand break (SSBR), and do…
View article: OGG1 as an Epigenetic Reader Affects NFκB: What This Means for Cancer
OGG1 as an Epigenetic Reader Affects NFκB: What This Means for Cancer Open
8-oxoguanine glycosylase 1 (OGG1), which was initially identified as the enzyme that catalyzes the first step in the DNA base excision repair pathway, is now also recognized as a modulator of gene expression. What is important for cancer i…
View article: The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection
The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection Open
SARS-CoV-2 infection-induced aggravation of host innate immune response not only causes tissue damage and multiorgan failure in COVID-19 patients but also induces host genome damage and activates DNA damage response pathways. To test wheth…
View article: OGG1 as an Epigenetic Reader Affects NFκB: What This Means for Cancer
OGG1 as an Epigenetic Reader Affects NFκB: What This Means for Cancer Open
8-oxoguanine glycosylase 1 (OGG1), which was initially identified as the enzyme that catalyzes the first step in the DNA base excision repair pathway, is now known also as a modulator of gene expression. What is important for cancer, is th…
View article: 8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-κB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276
8-Oxoguanine DNA glycosylase 1 selectively modulates ROS-responsive NF-κB targets through recruitment of MSK1 and phosphorylation of RelA/p65 at Ser276 Open
Nuclear factor kappa B (NF-κB) activity is regulated by various posttranslational modifications, of which Ser276 phosphorylation of RelA/p65 is particularly impacted by reactive oxygen species (ROS). This modification is responsible for se…
View article: Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury
Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury Open
Recent advances have uncovered the non-random distribution of 7, 8-dihydro-8-oxoguanine (8-oxoGua) induced by reactive oxygen species, which is believed to have epigenetic effects. Its cognate repair protein, 8-oxoguanine DNA glycosylase 1…
View article: Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1
Epigenetic control of type III interferon expression by 8-oxoguanine and its reader 8-oxoguanine DNA glycosylase1 Open
Interferons (IFNs) are secreted cytokines with the ability to activate expression of IFN stimulated genes that increase resistance of cells to virus infections. Activated transcription factors in conjunction with chromatin remodelers induc…
View article: Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection
Nei-like DNA glycosylase 2 selectively antagonizes interferon-β expression upon respiratory syncytial virus infection Open
View article: Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model
Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model Open
Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. IPF is currently treated with pirfenidone and nintedani…
View article: Is the proximal tubule the focus of tubulointerstitial fibrosis?
Is the proximal tubule the focus of tubulointerstitial fibrosis? Open
View article: 8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury
8-Oxoguanine targeted by 8-oxoguanine DNA glycosylase 1 (OGG1) is central to fibrogenic gene activation upon lung injury Open
Reactive oxygen species (ROS) are implicated in epithelial cell-state transition and deposition of extracellular matrix upon airway injury. Of the many cellular targets of ROS, oxidative DNA modification is a major driving signal. However,…
View article: Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice
Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice Open
Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by bc004004 gene, were expressed abundantly in brain tissues with unknown functions. We treated bc004004-/- mice with …
View article: Pharmacological OGG1 inhibition decreases murine allergic airway inflammation
Pharmacological OGG1 inhibition decreases murine allergic airway inflammation Open
Background and aim: Allergic asthma is a complex inflammatory disease involving type 2 innate lymphoid cells, type 2 T helper cells, macrophages, and eosinophils. The disease is characterized by wheezing, dyspnea, coughing, chest tightness…
View article: RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection
RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection Open
Respiratory syncytial virus (RSV), or human orthopneumovirus, is a negative-sense RNA virus that is the causative agent of severe lower respiratory tract infections in children and is associated with exacerbations of adult lung disease. Th…
View article: Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice
Lack of bombesin receptor–activated protein attenuates bleomycin-induced pulmonary fibrosis in mice Open
Bombesin receptor–activated protein (BRAP) was found to express in the interstitial cells of human fibrotic lungs with unknown function. Its homologous protein, encoded by BC004004 gene, was also present in mouse lung tissues. We used BC00…
View article: The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection
The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection Open
Compromised DNA repair capacity of individuals could play a critical role in the severity of SARS-CoV-2 infection-induced COVID-19. We therefore analyzed the expression of DNA repair genes in publicly available transcriptomic datasets of C…
View article: OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice
OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice Open
Allergic asthma is a complex disease characterized by dyspnea, coughing, chest tightness and airway remodeling, for which there is no cure and is symptomatically treated with inhaled β2-agonist and/or corticosteroids. Molecular mechanisms …
View article: OGG1 in Lung—More than Base Excision Repair
OGG1 in Lung—More than Base Excision Repair Open
As the organ executing gas exchange and directly facing the external environment, the lungs are challenged continuously by various stimuli, causing the disequilibration of redox homeostasis and leading to pulmonary diseases. The breakdown …
View article: CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway
CTNNAL1 participates in the regulation of mucus overproduction in HDM‐induced asthma mouse model through the YAP‐ROCK2 pathway Open
Our previous study indicated that adhesion molecule catenin alpha‐like 1(CTNNAL1) is downregulated in airway epithelial cells of asthma patients and asthma animal model but little is known about how the CTNNAL1 affects asthma pathogenesis.…
View article: Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice
Lack of bombesin receptor-activated protein homologous protein impairs hippocampal synaptic plasticity and promotes chronic unpredictable mild stress induced behavioral changes in mice Open
Bombesin receptor-activated protein (BRAP) and its homologous protein in mice, which is encoded by bc004004 gene, were expressed abundantly in brain tissues with unknown functions. We treated bc004004-/- mice with …
View article: Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions
Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions Open
The primary cause of morbidity and mortality from infection with respiratory syncytial virus (RSV) is the excessive innate immune response(s) (IIR) in which reactive oxygen species (ROS) play key role(s). However, the mechanisms for these …
View article: Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections
Endothelial Dysfunction through Oxidatively Generated Epigenetic Mark in Respiratory Viral Infections Open
The bronchial vascular endothelial network plays important roles in pulmonary pathology during respiratory viral infections, including respiratory syncytial virus (RSV), influenza A(H1N1) and importantly SARS-Cov-2. All of these infections…
View article: 8-oxoguanine DNA glycosylase1 recognizes oxidatively-generated epitranscriptomic marks on nascent mRNAs to promote RSV replication
8-oxoguanine DNA glycosylase1 recognizes oxidatively-generated epitranscriptomic marks on nascent mRNAs to promote RSV replication Open
Respiratory syncytial virus (RSV) infection induces an oxidizing environment linked to increased viral load, expression of pro-inflammatory genes, and excessive lung inflammation. The mechanisms of how reactive oxygen species (ROS) promote…
View article: Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription
Enzymatically inactive OGG1 binds to DNA and steers base excision repair toward gene transcription Open
8‐Oxoguanine DNA glycosylase1 (OGG1)‐initiated base excision repair (BER) is the primary pathway to remove the pre‐mutagenic 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) from DNA. Recent studies documented 8‐oxoG serves as an epigenetic‐like mark and…
View article: Epigenetic regulation of TIMP1 expression by 8‐oxoguanine DNA glycosylase‐1 binding to DNA:RNA hybrid
Epigenetic regulation of TIMP1 expression by 8‐oxoguanine DNA glycosylase‐1 binding to DNA:RNA hybrid Open
8‐Oxoguanine DNA glycosylase‐1 (OGG1)‐initiated base excision repair pathway is primarily responsible for 7, 8‐dihydro‐8‐oxoguanine (8‐oxoG) removal from DNA. Recent studies, however, have shown that 8‐oxoG in gene regulatory elements may …