Lixue Huang
YOU?
Author Swipe
View article: Identification of Key Biomarkers for Systemic Lupus Erythematosus Progression and Therapy Response: A Bulk RNA‐Sequencing‐Based Bioinformatics Study
Identification of Key Biomarkers for Systemic Lupus Erythematosus Progression and Therapy Response: A Bulk RNA‐Sequencing‐Based Bioinformatics Study Open
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs and has a higher prevalence in women of reproductive age. The increasing global incidence of this disease poses a significant public…
View article: Identification of basement membrane–associated genes as biomarkers for atrial fibrillation
Identification of basement membrane–associated genes as biomarkers for atrial fibrillation Open
Atrial fibrillation (AF) is the most common persistent arrhythmia, contributing substantially to morbidity, mortality, and healthcare burden. The basement membrane is essential for tissue homeostasis and disease regulation. Exploring the r…
View article: Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis
Vitamin A and vitamin B12 levels and coronary artery atherosclerosis: Univariate and multivariate Mendelian randomization analysis Open
Coronary artery atherosclerosis (CAA) stands as a prominent etiological contributor to global cardiovascular morbidity and mortality. Its pathogenesis entails intricate interplays among genetic predisposition, environmental factors, and li…
View article: Mendelian Randomization and Machine Learning Reveal Immune Cell and Gene Drivers in Systemic Lupus Erythematosus
Mendelian Randomization and Machine Learning Reveal Immune Cell and Gene Drivers in Systemic Lupus Erythematosus Open
Background Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unclear pathogenesis. Recent studies suggest that immune cell phenotypes may play a causal role. This study aimed to uncover causal immune cell types, key g…
View article: Mendelian randomisation and single-cell transcriptomic analyses reveal serotonin promotes multiple sclerosis progression by suppressing adenosine deaminase activity
Mendelian randomisation and single-cell transcriptomic analyses reveal serotonin promotes multiple sclerosis progression by suppressing adenosine deaminase activity Open
Objective To investigate the causal relationship between serotonin levels, adenosine deaminase (ADA) activity and multiple sclerosis (MS) progression using an integrative multi-omics approach. Methods and analysis A two-sample Mendelian ra…
View article: Integrated multi-omics analysis reveals diagnostic biomarkers and therapeutic targets for systemic lupus erythematosus
Integrated multi-omics analysis reveals diagnostic biomarkers and therapeutic targets for systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with poorly understood molecular mechanisms. This study investigated causal relationships between plasma proteins and SLE using two-sample Mendelian randomization analysis…
View article: Mendelian randomization investigation: Exploring the relationship between phosphatidylinositol levels and hypertrophic cardiomyopathy risk through interleukin-20 receptor subunit alpha expression
Mendelian randomization investigation: Exploring the relationship between phosphatidylinositol levels and hypertrophic cardiomyopathy risk through interleukin-20 receptor subunit alpha expression Open
This Mendelian randomization study investigated the causal relationship between phosphatidylinositol (PI) levels and hypertrophic cardiomyopathy (HCM) risk, while evaluating the potential mediating role of interleukin-20 receptor subunit a…
View article: Heterogeneous Activation of Signaling Pathways and Therapeutic Vulnerabilities in KSHV‐Associated Primary Effusion Lymphoma Cell Lines
Heterogeneous Activation of Signaling Pathways and Therapeutic Vulnerabilities in KSHV‐Associated Primary Effusion Lymphoma Cell Lines Open
Primary effusion lymphoma (PEL) is a rare and aggressive B‐cell malignancy caused by Kaposi's sarcoma‐associated herpesvirus (KSHV), with limited treatment options and poor prognosis. KSHV‐encoded proteins and miRNAs activate multiple sign…
View article: The improved prediction value of neutrophil to lymphocyte ratio to pneumonia severity scores for mortality in the older people with community-acquired pneumonia
The improved prediction value of neutrophil to lymphocyte ratio to pneumonia severity scores for mortality in the older people with community-acquired pneumonia Open
View article: Identification of key genes and diagnostic biomarkers for peripheral atherosclerosis: A multi-omics approach
Identification of key genes and diagnostic biomarkers for peripheral atherosclerosis: A multi-omics approach Open
Peripheral atherosclerosis (PAS), characterized by lipid plaque accumulation in arterial walls, significantly increases cardiovascular risk. This study aimed to identify molecular biomarkers and elucidate underlying mechanisms of PAS progr…
View article: Development and validation of a clinical-friendly model for predicting 180-day mortality in the older with community-acquired pneumonia
Development and validation of a clinical-friendly model for predicting 180-day mortality in the older with community-acquired pneumonia Open
This study developed and validated a prediction model for long-term mortality in older patients with CAP, showing better discriminatory power and accuracy over CURB-65.
View article: Intrinsic Capacity Deficits and 6-Month Outcomes in Older Adults with Acute LRTIs: A Multi-Center Study
Intrinsic Capacity Deficits and 6-Month Outcomes in Older Adults with Acute LRTIs: A Multi-Center Study Open
IC deficits were prevalent and associated with increased re-hospitalization in older adults with LRTIs. Early detection and targeted interventions may reduce re-hospitalization rates and improve patient outcomes.
View article: Efficacy and safety of isavuconazole versus voriconazole for the treatment of invasive fungal infections: a meta-analysis with trial sequential analysis
Efficacy and safety of isavuconazole versus voriconazole for the treatment of invasive fungal infections: a meta-analysis with trial sequential analysis Open
View article: Bidirectional Mendelian randomization reveals causal immune cell phenotypes in rheumatoid arthritis
Bidirectional Mendelian randomization reveals causal immune cell phenotypes in rheumatoid arthritis Open
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation in synovial joints and influenced by genetic and environmental factors. The immune system, comprising various cells that either exacerbate o…
View article: The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia
The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia Open
View article: Myeloid dendritic cells and periodontal disease association: integrated study of single-cell sequencing and Mendelian randomization analysis
Myeloid dendritic cells and periodontal disease association: integrated study of single-cell sequencing and Mendelian randomization analysis Open
Background Periodontal disease is a widespread inflammatory condition that compromises the supporting structures of the teeth, potentially resulting in tooth loss if left untreated. Despite advancements in therapeutic interventions and an …
View article: Post-COVID-19 condition symptoms 6–12 months after hospitalisation in Wuhan – Authors' reply
Post-COVID-19 condition symptoms 6–12 months after hospitalisation in Wuhan – Authors' reply Open
View article: Immune Responses in Discharged COVID-19 Patients With and Without Long COVID Symptoms
Immune Responses in Discharged COVID-19 Patients With and Without Long COVID Symptoms Open
The immune mechanisms of long coronavirus disease 2019 (COVID) are not yet fully understood. We aimed to investigate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific memory immune responses in discharged COVID-19 p…
View article: Association of Monocyte Count With Lung Function and Exercise Capacity Among Hospitalized COVID‐19 Survivors: A 2‐Year Cohort Study
Association of Monocyte Count With Lung Function and Exercise Capacity Among Hospitalized COVID‐19 Survivors: A 2‐Year Cohort Study Open
Background Abnormal changes of monocytes have been observed in acute COVID‐19, whereas associations of monocyte count with long COVID were not sufficiently elucidated. Methods A cohort study was conducted among COVID‐19 survivors discharge…
View article: Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors
Impact of corticosteroids on initiation and half-year durability of humoral response in COVID-19 survivors Open
View article: Risk factors associated with functional decline in older hospital survivors with acute lower respiratory tract infections: a prospective cohort study
Risk factors associated with functional decline in older hospital survivors with acute lower respiratory tract infections: a prospective cohort study Open
Objective To evaluate the dynamics of basic activity of daily living (BADL) in older patients with acute lower respiratory tract infections (LRTIs) during acute phase and to investigate risk factors associated with decreased physical funct…
View article: Recurrent and persistent fever after SARS-CoV-2 infection in patients with follicular lymphoma: A case series
Recurrent and persistent fever after SARS-CoV-2 infection in patients with follicular lymphoma: A case series Open
Although persistent or recurrent COVID-19 infection is well described in some immunosuppressed patient cohort, to date, there have been no reports of this phenomenon in the context of repeatedly negative SARS-CoV-2 testing in the upper res…
View article: Association between cardiopulmonary bypass time and mortality among patients with acute respiratory distress syndrome after cardiac surgery
Association between cardiopulmonary bypass time and mortality among patients with acute respiratory distress syndrome after cardiac surgery Open
Background Cardiopulmonary bypass (CPB) can lead to lung injury and even acute respiratory distress syndrome (ARDS) through triggering systemic inflammatory response. The objective of this study was to investigate the impact of CPB time on…
View article: Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors
Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors Open
National Natural Science Foundation of China; Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences; Clinical Research Operating Fund of Central High Level Hospitals; the Talent Program of the Chinese Academy of M…
View article: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study
6-month consequences of COVID-19 in patients discharged from hospital: a cohort study Open
View article: Association between cardiopulmonary bypass time and clinical outcomes among patients with acute respiratory distress syndrome after cardiac surgery
Association between cardiopulmonary bypass time and clinical outcomes among patients with acute respiratory distress syndrome after cardiac surgery Open
Background: Cardiopulmonary bypass (CPB) can lead to lung injury and even acute respiratory distress syndrome (ARDS) through triggering systemic inflammatory response. The objective of this study was to investigate the impact of CPB time o…
View article: Lung-function trajectories in COVID-19 survivors after discharge: A two-year longitudinal cohort study
Lung-function trajectories in COVID-19 survivors after discharge: A two-year longitudinal cohort study Open
This work was supported by Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (CIFMS 2021-I2M-1-048) and the National Key Research and Development Program of China (2021YFC0864700).
View article: A glimpse into long COVID and symptoms – Authors' reply
A glimpse into long COVID and symptoms – Authors' reply Open
View article: Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study
Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study Open
View article: Rheumatic Symptoms Following Coronavirus Disease 2019 (COVID-19): A Chronic Post–COVID-19 Condition
Rheumatic Symptoms Following Coronavirus Disease 2019 (COVID-19): A Chronic Post–COVID-19 Condition Open
Background Detailed characteristics of rheumatic symptoms of coronavirus disease 2019 (COVID-19) were still unknown. We aim to investigate the proportions, characteristics, and risk factors of this condition. Methods In this prospective, l…