Liya Gu
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View article: Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS–STING-dependent apoptosis
Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS–STING-dependent apoptosis Open
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin ( HTT ) gene. The repeat-expanded HTT encodes a mutated HTT (mHTT), which is known to induce DNA double-strand breaks (…
View article: Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy
Heat shock protein DNAJA2 regulates transcription-coupled repair by triggering CSB degradation via chaperone-mediated autophagy Open
Transcription-coupled nucleotide excision repair (TC-NER) is an important genome maintenance system that preferentially removes DNA lesions on the transcribed strand of actively transcribed genes, including non-coding genes. TC-NER involve…
View article: The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks
The mismatch recognition protein MutSα promotes nascent strand degradation at stalled replication forks Open
Mismatch repair (MMR) is a replication-coupled DNA repair mechanism and plays multiple roles at the replication fork. The well-established MMR functions include correcting misincorporated nucleotides that have escaped the proofreading acti…
View article: Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair
Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair Open
DNA mismatch repair (MMR) relies on MutS and MutL ATPases for mismatch recognition and strand-specific nuclease recruitment to remove mispaired bases in daughter strands. However, whether the MutS–MutL complex coordinates MMR by ATP-depend…
View article: Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas
Author Correction: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Correction: Phosphorylation of proliferating cell nuclear antigen promotes cancer progression by activating the ATM/Akt/GSK3β/Snail signaling pathway.
Correction: Phosphorylation of proliferating cell nuclear antigen promotes cancer progression by activating the ATM/Akt/GSK3β/Snail signaling pathway. Open
VOLUME 294 (2019) PAGES 7037–7045 The affiliation for the corresponding author was missing information. The correct footnote should read as follows. Holder of a CPRIT Scholar in Cancer Research and the Reece A. Overcash, Jr. Chair for Rese…
View article: Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas
Identification of novel genetic variants predisposing to familial oral squamous cell carcinomas Open
Oral squamous cell carcinoma (OSCC) is a common subtype of head and neck squamous cell carcinoma (HNSCC), but the pathogenesis underlying familial OSCCs is unknown. Here, we analyzed whole-genome sequences of a family with autosomal domina…
View article: Mechanism of Curcuma wenyujin Rhizoma on Acute Blood Stasis in Rats Based on a UPLC-Q/TOF-MS Metabolomics and Network Approach
Mechanism of Curcuma wenyujin Rhizoma on Acute Blood Stasis in Rats Based on a UPLC-Q/TOF-MS Metabolomics and Network Approach Open
Rhizome of Curcuma wenyujin, which is called EZhu in China, is a traditional Chinese medicine used to treat blood stasis for many years. However, the underlying mechanism of EZhu is not clear at present. In this study, plasma metabolomics …
View article: Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction
Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction Open
Significance Somatic mutations converting glycine 34 of histone H3 (H3G34) to a large side chain-containing residue (e.g., arginine, valine) cause pediatric gliomas; however, the mechanism of this is unknown. Because H3K36me3 is involved i…
View article: H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation
H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation Open
Histone H3 trimethylation at lysine 36 (H3K36me3) is an important histone mark involved in both transcription elongation and DNA mismatch repair (MMR). It is known that H3K36me3 recruits the mismatch-recognition protein MutSα to replicatin…
View article: Supplementary Material for: Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients
Supplementary Material for: Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients Open
Background: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD. Methods: This is a multicente…
View article: PowerPoint Slides for: Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients
PowerPoint Slides for: Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients Open
Background: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD. Methods: This is a multicente…
View article: PowerPoint Slides for: Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients
PowerPoint Slides for: Prognostic Value of the Delivery Dialysis Dose on Twice-Weekly Hemodialysis Patients Open
Background: Few studies have evaluated the prognostic value of dialysis dose in twice-weekly hemodialysis (HD). A single-pool Kt/V (spKt/V) over 1.70 may benefit patients receiving twice-weekly maintenance HD. Methods: This is a multicente…
View article: Arsenic Inhibits DNA Mismatch Repair by Promoting EGFR Expression and PCNA Phosphorylation
Arsenic Inhibits DNA Mismatch Repair by Promoting EGFR Expression and PCNA Phosphorylation Open
Both genotoxic and non-genotoxic chemicals can act as carcinogens. However, while genotoxic compounds lead directly to mutations that promote unregulated cell growth, the mechanism by which non-genotoxic carcinogens lead to cellular transf…
View article: Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA
Human DNA Exonuclease TREX1 Is Also an Exoribonuclease That Acts on Single-stranded RNA Open
3' repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the antiviral response. In this work, we show that TREX1 is also a RNA exonuclease. Purified TREX1 displays robust exoribonuclease activity tha…
View article: Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis
Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis Open
Significance DNA replication accuracy is critical for genetic stability and is ensured by high-fidelity replicative DNA polymerases and the mismatch repair (MMR) system, both of which are regulated by the proliferating cell nuclear antigen…