Liyan Gu
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View article: Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion
Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion Open
Background Despite the remarkable clinical outcomes of epidermal growth factor receptor (EGFR)-targeted therapies in patients with lung cancer, therapeutic resistance eventually develops. This study elucidates the role of galectin-9 (Gal-9…
View article: Overcoming resistance in HER2-positive gastric cancer: a case report on the synergistic effect of pembrolizumab and trastuzumab
Overcoming resistance in HER2-positive gastric cancer: a case report on the synergistic effect of pembrolizumab and trastuzumab Open
Introduction: The first-line standard therapy for advanced HER2-positive gastric cancer is chemotherapy combined with trastuzumab and pembrolizumab, while pembrolizumab alone does not benefit as a monotherapy in patients with mismatch repa…
View article: Effectiveness of preoperative oral nutritional supplements in colorectal cancer patients undergoing surgery: A systematic review and meta analysis
Effectiveness of preoperative oral nutritional supplements in colorectal cancer patients undergoing surgery: A systematic review and meta analysis Open
Summary: Background & aims: Poor nutritional status has been shown to have a detrimental effect on the prognosis of patients undergoing surgery. Oral nutritional supplements (ONS) are commonly used in the preoperative period to improve the…
View article: Prolonged usage of fosaprepitant for prevention of delayed chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly emetogenic chemotherapy
Prolonged usage of fosaprepitant for prevention of delayed chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly emetogenic chemotherapy Open
Background Even though chemotherapy-induced nausea and vomiting (CINV) can be well controlled in the acute phase, the incidence of delayed CINV remains high. In this study, we intend to investigate whether prolonged use of NK-1 receptor an…
View article: Prolonged usage of fosaprepitant for prevention of delayed CINV in patients receiving highly emetogenic chemotherapy
Prolonged usage of fosaprepitant for prevention of delayed CINV in patients receiving highly emetogenic chemotherapy Open
Background: Even though chemotherapy-induced nausea and vomiting (CINV) can be well controlled in the acute phase, the incidence of delayedCINV remains high. In this study, we intend to investigate whether prolonged use of NK-1 receptor an…
View article: TP53 Mutation Mapping in Advanced Non-Small Cell Lung Cancer: A Real-World Retrospective Cohort Study
TP53 Mutation Mapping in Advanced Non-Small Cell Lung Cancer: A Real-World Retrospective Cohort Study Open
Background: TP53 is frequently mutated in solid tumors, but its basic mutation mapping is mixed, particularly in aggressive-stage lung cancer. Experimental Design: We curated a total of 139 advanced non-small cell lung cancer (NSCLC) patie…
View article: Prolonged usage of fosaprepitant for prevention of delayed CINV in patients receiving highly emetogenic chemotherapy
Prolonged usage of fosaprepitant for prevention of delayed CINV in patients receiving highly emetogenic chemotherapy Open
Background: Even though chemotherapy-induced nausea and vomiting (CINV) can be well controlled in the acute phase, the incidence of delayed CINV remains high. In this study, we intend to investigate whether prolonged use of NK-1 receptor a…
View article: Retrospective study of <scp>EGFR</scp>‐mutant lung adenocarcinoma with bone metastatic clinical features
Retrospective study of <span>EGFR</span>‐mutant lung adenocarcinoma with bone metastatic clinical features Open
Background With more and more target medicine application in lung cancer, lots of patients take medicine at home, the treatment bone metastasis and screen of bone metastasis always has been neglected until skeletal‐related events (SREs) su…
View article: Application of Multifunctional Targeting Epirubicin Liposomes in the Treatment of Non-Small-Cell Lung Cancer [Corrigendum]
Application of Multifunctional Targeting Epirubicin Liposomes in the Treatment of Non-Small-Cell Lung Cancer [Corrigendum] Open
[This corrects the article DOI: 10.2147/IJN.S141787.].
View article: Effects of comprehensive care on complications, oxygenation indexes and guardian's psychological mood of children with neonatal respiratory distress syndrome.
Effects of comprehensive care on complications, oxygenation indexes and guardian's psychological mood of children with neonatal respiratory distress syndrome. Open
Comprehensive care is effective for children with NRDS, which can improve oxygenation indexes and lung injury, reduce the incidence of complications, and improve the psychological mood of parents.
View article: Totally implantable venous access devices: The supraclavicular percutaneous approach and early complications
Totally implantable venous access devices: The supraclavicular percutaneous approach and early complications Open
It is safe and feasible to implant TIVADs by supraclavicular venipuncture. Ultrasound guidance combined with X-ray monitoring during operation significantly improves the surgery success rate and reduces the risk of early complications. Unc…
View article: [Molecular Mechanism and Progression of Primary Resistance to EGFR-TKI
- Analysis of 2 Cases].
[Molecular Mechanism and Progression of Primary Resistance to EGFR-TKI
- Analysis of 2 Cases]. Open
Tyrosine kinase inhibitor (TKI) have been proved to be effective in the treatment of advanced non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) sensitive mutation, which is superior to chemotherapy. H…
View article: Retrospective study of the efficacy and toxicity of lobaplatin‐etoposide chemotherapy in small cell lung cancer
Retrospective study of the efficacy and toxicity of lobaplatin‐etoposide chemotherapy in small cell lung cancer Open
Background A retrospective study was conducted to assess the efficacy and toxicity of lobaplatin‐etoposide (EL) chemotherapy for small cell lung cancer (SCLC). Methods The clinical data of 50 patients treated in our department from May 201…
View article: MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands
MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands Open
Hyperplasia of mammary glands (HMG) is also termed mammary dysplasia. In China, the number of patients suffering from breast hyperplasia is increasing annually. MicroRNAs (miRNAs; length, 19-24 nucleotides), a group of small endogenous non…
View article: Shenqi Fuzheng Injection Reverses Cisplatin Resistance through Mitofusin‐2‐Mediated Cell Cycle Arrest and Apoptosis in A549/DDP Cells
Shenqi Fuzheng Injection Reverses Cisplatin Resistance through Mitofusin‐2‐Mediated Cell Cycle Arrest and Apoptosis in A549/DDP Cells Open
The goal of this evaluation was to examine the mechanisms of Shenqi Fuzheng injection (SFI), an extract made from the plants Radix Astragali and Radix Codonopsis , in the process of chemotherapy sensitivity in non‐small‐cell lung cancer (N…
View article: Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer
Application of multifunctional targeting epirubicin liposomes in the treatment of non-small-cell lung cancer Open
Chemotherapy for aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe systemic toxicity. Herein, we develo…