Liyan Mao
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View article: Risk Factor Analysis of CRE Infections at Different Anatomical Sites in ICU Patients
Risk Factor Analysis of CRE Infections at Different Anatomical Sites in ICU Patients Open
Objectives: This study aimed to identify differences in risk factors for carbapenem-resistant Enterobacteriaceae (CRE) infections across different anatomical sites and to explore risk factors associated with mortality in CRE-infected patie…
View article: Nymphaea “Eldorado” flower extract targets serpine 1 to attenuate inflammatory and antioxidant crosstalk in zebrafish
Nymphaea “Eldorado” flower extract targets serpine 1 to attenuate inflammatory and antioxidant crosstalk in zebrafish Open
Chronic inflammation and oxidative stress are pivotal drivers of pathological conditions, necessitating safer plant-derived therapeutic alternatives. This study elucidates the anti-inflammatory and antioxidant mechanisms of Nymphaea “Eldor…
View article: [Risk prediction of demoralization syndrome in patients with oral cancer].
[Risk prediction of demoralization syndrome in patients with oral cancer]. Open
Our risk prediction mo-del of the demoralization syndrome in patients with oral cancer performed robustly in validation cohorts of different nur-sing environments. The model has good correction and good discrimination and can be used as an…
View article: A tympanitis-related brain abscess caused by Helcococcus kunzii in China: a case report and literature review
A tympanitis-related brain abscess caused by Helcococcus kunzii in China: a case report and literature review Open
Background Infections attributed to Helcococcus kunzii are rarely documented, especially in relation to brain abscesses. This study aims to report the first documented case of a brain abscess associated with tympanitis caused by H. kunzii …
View article: Blood-based diagnosis of pediatric tuberculosis: A prospective cohort study in South Africa and Dominican Republic
Blood-based diagnosis of pediatric tuberculosis: A prospective cohort study in South Africa and Dominican Republic Open
Serum MAP-TB results can effectively diagnose pediatric TB, including unconfirmed and extrapulmonary TB missed by current methods, and correspond to effective treatment.
View article: A complicated case of refractory multiple drug-resistant peritoneal dialysis-associated peritonitis due to teratoma
A complicated case of refractory multiple drug-resistant peritoneal dialysis-associated peritonitis due to teratoma Open
Peritoneal dialysis-associated peritonitis is a leading cause of treatment discontinuation and mortality among peritoneal dialysis patients. The presence of multidrug-resistant organisms further complicates management, particularly in pati…
View article: Multicentre evaluation of <i>in vitro</i> activity of contezolid against drug-resistant <i>Staphylococcus</i> and <i>Enterococcus</i>
Multicentre evaluation of <i>in vitro</i> activity of contezolid against drug-resistant <i>Staphylococcus</i> and <i>Enterococcus</i> Open
Background To investigate susceptibility to contezolid, a novel oxazolidinone, multicentre surveillance was conducted involving 2449 strains of Staphylococcus and Enterococcus collected from 65 hospitals across China. Methods The MICs of c…
View article: Using immune clusters for classifying Mycobacterium tuberculosis infection
Using immune clusters for classifying Mycobacterium tuberculosis infection Open
We depicted the immune landscape of patients with ATB and LTBI. Three immune subtypes were identified in ATB patients with different severity.
View article: Aquilaria sinensis leaf tea affects the immune system and increases sleep in zebrafish
Aquilaria sinensis leaf tea affects the immune system and increases sleep in zebrafish Open
The importance of adequate sleep for good health cannot be overstated. Excessive light exposure at night disrupts sleep, therefore, it is important to find more healthy drinks that can promote sleep under sleep-disturbed conditions. The pr…
View article: Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum
Nanopore-based disease diagnosis using pathogen-derived tryptic peptides from serum Open
Nanopore sensors have shown great utility in nucleic acid detection and sequencing approaches. Recent studies also indicate that current signatures produced by peptide-nanopore interactions can distinguish high purity peptide mixtures, but…
View article: <scp>CD39</scp> pathway inhibits Th1 cell function in tuberculosis
<span>CD39</span> pathway inhibits Th1 cell function in tuberculosis Open
The role of CD39 pathway in Th1 cell function in tuberculosis (TB) is rarely elucidated. The present study aims to investigate the modulating mechanism of CD39 pathway during Mycobacterium tuberculosis (MTB) infection. CD39 expression was …
View article: Diagnostic Model for Discrimination Between Tuberculous Meningitis and Bacterial Meningitis
Diagnostic Model for Discrimination Between Tuberculous Meningitis and Bacterial Meningitis Open
Background The differential diagnosis between tuberculous meningitis (TBM) and bacterial meningitis (BM) remains challenging in clinical practice. This study aimed to establish a diagnostic model that could accurately distinguish TBM from …
View article: Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection
Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells and Tuberculosis Antigen/Phytohemagglutinin Ratio for Discriminating Active Tuberculosis From Latent Tuberculosis Infection Open
Background Novel approaches for tuberculosis (TB) diagnosis, especially for distinguishing active TB (ATB) from latent TB infection (LTBI), are urgently warranted. The present study aims to determine whether the combination of HLA-DR on My…
View article: The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes
The Dynamic Immunological Parameter Landscape in Coronavirus Disease 2019 Patients With Different Outcomes Open
Objectives The longitudinal and systematic evaluation of immunity in coronavirus disease 2019 (COVID-19) patients is rarely reported. Methods Parameters involved in innate, adaptive, and humoral immunity were continuously monitored in COVI…
View article: Activation Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells Promoting the Discrimination Between Active Tuberculosis and Latent Tuberculosis Infection
Activation Phenotype of Mycobacterium tuberculosis-Specific CD4+ T Cells Promoting the Discrimination Between Active Tuberculosis and Latent Tuberculosis Infection Open
Background Rapid and effective discrimination between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains a challenge. There is an urgent need for developing practical and affordable approaches targeting this issue. …
View article: Lymphocyte-Related Immunological Indicators for Stratifying Mycobacterium tuberculosis Infection
Lymphocyte-Related Immunological Indicators for Stratifying Mycobacterium tuberculosis Infection Open
Background Easily accessible tools that reliably stratify Mycobacterium tuberculosis (MTB) infection are needed to facilitate the improvement of clinical management. The current study attempts to reveal lymphocyte-related immune characteri…
View article: Combination of Blood Routine Examination and T-SPOT.TB Assay for Distinguishing Between Active Tuberculosis and Latent Tuberculosis Infection
Combination of Blood Routine Examination and T-SPOT.TB Assay for Distinguishing Between Active Tuberculosis and Latent Tuberculosis Infection Open
Background Distinguishing between active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remains challenging. Methods Between 2013 and 2019, 2,059 (1,097 ATB and 962 LTBI) and another 883 (372 ATB and 511 LTBI) participants wer…
View article: Lymphocyte Non-Specific Function Detection Facilitating the Stratification of Mycobacterium tuberculosis Infection
Lymphocyte Non-Specific Function Detection Facilitating the Stratification of Mycobacterium tuberculosis Infection Open
Background Inadequate tuberculosis (TB) diagnostics, especially for discrimination between active TB (ATB) and latent TB infection (LTBI), are major hurdle in the reduction of the disease burden. The present study aims to investigate the r…
View article: Using Routine Laboratory Markers and Immunological Indicators for Predicting Pneumocystis jiroveci Pneumonia in Immunocompromised Patients
Using Routine Laboratory Markers and Immunological Indicators for Predicting Pneumocystis jiroveci Pneumonia in Immunocompromised Patients Open
Background Pneumocystis jiroveci pneumonia (PJP) is the most common opportunistic infection in immunocompromised patients. The accurate prediction of PJP development in patients undergoing immunosuppressive therapy remains challenge. Metho…
View article: Diagnostic Value of T-SPOT.TB Assay for Tuberculous Peritonitis: A Meta-Analysis
Diagnostic Value of T-SPOT.TB Assay for Tuberculous Peritonitis: A Meta-Analysis Open
Background: Tuberculous peritonitis (TP) is a common form of abdominal tuberculosis (TB). Diagnosing TP remains challenging in clinical practice. The aim of the present meta-analysis was to evaluate the diagnostic accuracy of peripheral bl…
View article: Combination of prealbumin and tuberculosis‐specific antigen/phytohemagglutinin ratio for discriminating active tuberculosis from latent tuberculosis infection
Combination of prealbumin and tuberculosis‐specific antigen/phytohemagglutinin ratio for discriminating active tuberculosis from latent tuberculosis infection Open
The diagnostic model based on combination of prealbumin and TBAg/PHA ratio is a rapid and accurate tool for discriminating ATB from LTBI.
View article: The Effect of Host Immunity on Predicting the Mortality of Carbapenem-Resistant Organism Infection
The Effect of Host Immunity on Predicting the Mortality of Carbapenem-Resistant Organism Infection Open
Carbapenem-resistant organisms (CROs) are associated with considerable mortality clinically. There is a lack of effective tool to predict individual prognosis. We aim to determine if host immunity can be utilized to predict the prognosis o…
View article: Diagnostic Accuracy of T-SPOT.TB Assay for Tuberculous Meningitis: An Updated Meta-Analysis
Diagnostic Accuracy of T-SPOT.TB Assay for Tuberculous Meningitis: An Updated Meta-Analysis Open
Background: The role of T-SPOT.TB (T-SPOT) assay for tuberculous meningitis (TBM) diagnosis has not been fully assessed. Here, we conducted an updated meta-analysis to evaluate the diagnostic accuracy of peripheral blood (PB) T-SPOT and ce…
View article: Prediction Model Based on the Combination of Cytokines and Lymphocyte Subsets for Prognosis of SARS-CoV-2 Infection
Prediction Model Based on the Combination of Cytokines and Lymphocyte Subsets for Prognosis of SARS-CoV-2 Infection Open
Background There are currently rare satisfactory markers for predicting the death of patients with coronavirus disease 2019 (COVID-19). The aim of this study is to establish a model based on the combination of serum cytokines and lymphocyt…
View article: Prealbumin as a Predictor of Prognosis in Patients With Coronavirus Disease 2019
Prealbumin as a Predictor of Prognosis in Patients With Coronavirus Disease 2019 Open
Background: The predictive value of prealbumin for the prognosis of coronavirus disease 2019 (COVID-19) has not been extensively investigated. Methods: A total of 1,115 patients with laboratory-confirmed COVID-19 were enrolled at Tongji ho…
View article: A combination of iron metabolism indexes and tuberculosis-specific antigen/phytohemagglutinin ratio for distinguishing active tuberculosis from latent tuberculosis infection
A combination of iron metabolism indexes and tuberculosis-specific antigen/phytohemagglutinin ratio for distinguishing active tuberculosis from latent tuberculosis infection Open
The data suggest that the combination of iron metabolism indexes and TBAg/PHA ratio could serve as a biomarker to distinguish ATB from LTBI in T-SPOT-positive individuals.