Liyong Pu
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View article: Supplementary Table S1 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Table S1 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Supplementary Table. S1: Included control and NASH patients grouping and cohort information.
View article: Supplementary Figure S2 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S2 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S2: Myeloid Trem2 promotes CD9+NAM differentiation.
View article: Supplementary Figure S5 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S5 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S5: Trem2Δmye-induced accumulation of monocytes/pro-inflammatory macrophages increases the degradation of NETs
View article: Supplementary Table S3 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Table S3 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Supplementary Table. S3: Panel of antibodies used for CyTOF
View article: Data from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Data from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Macrophages expressing Trem2 play a pivotal role in promoting nonalcoholic steatohepatitis (NASH; also known as metabolic dysfunction–associated steatohepatitis) progression to hepatocellular carcinoma (HCC). Despite the widespread clinica…
View article: Supplementary Figure S4 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S4 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S4: Myeloid Trem2-driven NASH carcinogenesis is partially dependent on NETs formation
View article: Supplementary Figure S6 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S6 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S6: The reduction of Tregs caused by myeloid Trem2-knockout is related to the inhibition of NETs formation
View article: Supplementary Figure S1 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S1 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S1: Up-regulation of Trem2 in NAM Promotes the Immunosuppressive Phenotype Differentiation in NASH.
View article: Supplementary Table S4 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Table S4 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Supplementary Table S4: Primers for RT-qPCR.
View article: Supplementary Table S2 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Table S2 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Supplementary Table. S2: General characteristics of included control, NASH and NASH-related HCC Patients from the First Affiliated Hospital of Nanjing Medical University
View article: Supplementary Figure S7 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S7 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S7: Deletion of myeloid Trem2 reduces TGFβ in NASH
View article: Supplementary Figure S3 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S3 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S3: Lack of myeloid Trem2 induces accumulation of apoptotic neutrophil in NASH liver
View article: Supplementary Figure S8 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis
Supplementary Figure S8 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis Open
Fig. S8: Inhibition of CXCR2 further enhances the efficacy of targeting myeloid Trem2+anti-PD-1 in the treatment of NASH-driven HCC
View article: Alteration characteristics and short wavelength infrared (SWIR) spectroscopy of the Huangtupo Cu-Zn VMS deposit, NW China: Implications for ore genesis and exploration
Alteration characteristics and short wavelength infrared (SWIR) spectroscopy of the Huangtupo Cu-Zn VMS deposit, NW China: Implications for ore genesis and exploration Open
View article: Oxidized Phospholipids Aggravate Hepatic Ischemia/Reperfusion Injury by Promoting Macrophage M1 Polarization via Regulating the Wnt/β-Catenin/Autophagy Axis
Oxidized Phospholipids Aggravate Hepatic Ischemia/Reperfusion Injury by Promoting Macrophage M1 Polarization via Regulating the Wnt/β-Catenin/Autophagy Axis Open
Hepatic ischemia-reperfusion injury (IRI) remains an unavoidable consequence of partial hepatic resection and liver transplantation. Oxidative stress damages cellular lipid membranes, causing the formation of oxidized phospholipids (OxPLs)…
View article: Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis
Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis Open
View article: Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis
Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis Open
Background Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastases. Colorectal live…
View article: Establishment of two novel organoid lines from patients with combined hepatocellular cholangiocarcinoma
Establishment of two novel organoid lines from patients with combined hepatocellular cholangiocarcinoma Open
Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a unique subtype of primary liver cancer displaying both hepatocytic and cholangiocytic differentiation. The development of effective treatments for cHCC-CCA remains challenging beca…
View article: SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence
SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence Open
View article: SYK Promotes the Formation of Neutrophil Extracellular Traps by Inducing PKM2 Nuclear Translocation and Promoting STAT3 Phosphorylation to Exacerbate Hepatic Ischemia-Reperfusion Injury and Tumor Recurrence
SYK Promotes the Formation of Neutrophil Extracellular Traps by Inducing PKM2 Nuclear Translocation and Promoting STAT3 Phosphorylation to Exacerbate Hepatic Ischemia-Reperfusion Injury and Tumor Recurrence Open
Background At present, hepatic ischemia-reperfusion injury (IRI) is an important complication of partial hepatectomy and liver transplantation, and it is an important cause of poor prognosis. Spleen tyrosine kinase(SYK) plays an important …
View article: Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury
Novel anti-inflammatory peptide alleviates liver ischemia-reperfusion injury Open
Ischemia-reperfusion injury (IRI) remains an unavoidable challenge in liver surgery, with macrophages playing a critical role in its pathogenesis. However, the mechanisms by which macrophages regulate the pathogenesis of IRI are not well u…
View article: Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma
Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma Open
Here, we reported that hypoxia-induced endothelial cell-specific DGKG hyper-expression promotes angiogenesis and immune evasion in HCC by recruiting USP16 for K48-linked deubiquitination and inducing the subsequent stabilization of ZEB2, l…
View article: Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin–Mediated Mitophagy
Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin–Mediated Mitophagy Open
View article: Correction: miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6
Correction: miR-146a Ameliorates Liver Ischemia/Reperfusion Injury by Suppressing IRAK1 and TRAF6 Open
[This corrects the article DOI: 10.1371/journal.pone.0101530.].
View article: Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners
Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners Open
Metabolic reprogramming plays a crucial role in the development of hepatocellular carcinoma (HCC). However, the key drivers of metabolic reprogramming underlying HCC progression remain unclear. Using a large-scale transcriptomic database a…
View article: Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation
Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation Open
Trem2, a transmembrane protein that is simultaneously expressed in both bone marrow-derived and embryonic-derived liver-resident macrophages, plays a complex role in liver inflammation. The unique role of myeloid Trem2 in hepatic ischemia-…
View article: Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3 Open
Background Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liver metastasis (CRLM…
View article: Aging deteriorated liver Ischemia and reperfusion injury by suppressing Tribble’s proteins 1 mediated macrophage polarization
Aging deteriorated liver Ischemia and reperfusion injury by suppressing Tribble’s proteins 1 mediated macrophage polarization Open
Aggravated liver injury has been reported in aged ischemia/reperfusion-stressed livers; however, the mechanism of aged macrophage inflammatory regulation is not well understood. Here, we found that the adaptor protein TRIB1 plays a critica…
View article: Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3
Hepatocyte SGK1 activated by hepatic ischemia-reperfusion promotes the recurrence of liver metastasis via IL-6/STAT3 Open
Background Liver metastasis is the leading cause of death in patients with colorectal cancer (CRC). Surgical resection of the liver metastases increases the incidence of long-term survival in patients with colorectal liver metastasis (CRLM…
View article: PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells Open