Liyong Yang
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View article: Evolution of Potential Distribution Areas and Cultivation Zones of Morchella esculenta (L.) Pers. Under Climate Warming: Application of Ensemble Models and Production Dynamics Models
Evolution of Potential Distribution Areas and Cultivation Zones of Morchella esculenta (L.) Pers. Under Climate Warming: Application of Ensemble Models and Production Dynamics Models Open
Under global climate change, sustainable management of plant resources in alpine canyon regions faces severe challenges. M. esculenta, highly valued for its edible and medicinal properties, is widely harvested for consumption by residents …
View article: TLR4 mediates lipotoxic β-cell dysfunction by inhibiting the TMEM24/PI3K/AKT pathway
TLR4 mediates lipotoxic β-cell dysfunction by inhibiting the TMEM24/PI3K/AKT pathway Open
Immune imbalance is the core pathophysiological mechanism of the deterioration of β-cell function driven by lipid metabolism disorders. Toll-like receptor 4 (TLR4) inflammatory signaling is a key pathway that mediates lipotoxic injury in β…
View article: High-intensity interval swimming improves cardiovascular endurance, while aquatic resistance training enhances muscular strength in older adults
High-intensity interval swimming improves cardiovascular endurance, while aquatic resistance training enhances muscular strength in older adults Open
The aim of this study was to examine the effects of free swimming (FS), aquatic resistance training (ART), and their combination (FS&ART) on the body composition, blood pressure, and physical fitness of older adults. The study employed a r…
View article: Prediction of the Potential Distribution and Conservation Strategies of the Endangered Plant Tapiscia sinensis
Prediction of the Potential Distribution and Conservation Strategies of the Endangered Plant Tapiscia sinensis Open
Tapiscia sinensis Oliv. (T. sinensis), known as the Yingjiao tree, belongs to the Staphyleaceae family. It is a deciduous tree species endemic to China and represents an ancient species from the Tertiary glacial relics, possessing signific…
View article: Modeling the potential distribution of the energy tree species Triadica sebifera in response to climate change in China
Modeling the potential distribution of the energy tree species Triadica sebifera in response to climate change in China Open
View article: Retraction Note: The effect of n-3/n-6 polyunsaturated fatty acids on acute reflux esophagitis in rats
Retraction Note: The effect of n-3/n-6 polyunsaturated fatty acids on acute reflux esophagitis in rats Open
View article: Mapping of the Waxy Gene in Brassica napus L. via Bulked Segregant Analysis (BSA) and Whole-Genome Resequencing
Mapping of the Waxy Gene in Brassica napus L. via Bulked Segregant Analysis (BSA) and Whole-Genome Resequencing Open
Plant cuticular wax is the covering of the outer layer of the plant. It forms a protective barrier on the epidermis of plants and plays a vital role like a safeguard from abiotic and biotic stresses. In the present study, Brassica napus L.…
View article: Global transcriptome analysis reveals potential genes associated with genic male sterility of rapeseed (Brassica napus L.)
Global transcriptome analysis reveals potential genes associated with genic male sterility of rapeseed (Brassica napus L.) Open
Rapeseed is the third leading source of edible oil in the world. Genic male sterility (GMS) lines provide crucial material for harnessing heterosis for rapeseed. GMS lines have been widely used successfully for rapeseed hybrid production. …
View article: Pre-treatment controlling nutritional status (CONUT) score and carcinoembryonic antigen level provide tumour progression and prognostic information in gastric cancer: a retrospective study
Pre-treatment controlling nutritional status (CONUT) score and carcinoembryonic antigen level provide tumour progression and prognostic information in gastric cancer: a retrospective study Open
Background : This study explores the role of combining the controlling nutritional status (CONUT) score and the carcinoembryonic antigen (CEA) level on predicting tumour stage and prognosis in gastric cancer (GC) patients. Methods: A total…
View article: QTL mapping for low temperature germination in rapeseed
QTL mapping for low temperature germination in rapeseed Open
Rapeseed, a major oil crop in the world, is easily affected by low-temperature stress. A low temperature delays seed germination and increases seedling mortality, adversely affecting rapeseed growth and production. In the present study, a …
View article: Identification of miRNAs and their target genes in genic male sterility lines in Brassica napus by small RNA sequencing
Identification of miRNAs and their target genes in genic male sterility lines in Brassica napus by small RNA sequencing Open
Background Brassica napus is the third leading source of edible oil in the world. Genic male sterility (GMS) lines provide crucial material for harnessing heterosis for rapeseed. GMS lines have been used successfully for rapeseed hybrid pr…
View article: QTLs Detection for Low-Temperature Germination in Rapeseed by QTL-seq and Linkage Mapping Approach
QTLs Detection for Low-Temperature Germination in Rapeseed by QTL-seq and Linkage Mapping Approach Open
Rapeseed is a major oil crop in the world, which is easily affected by low-temperature stress. Low-temperature delays seed germination and increases seedling mortality that adversely affects rapeseed growth and production. To understand th…
View article: Global Analysis of the Genetic Variations in miRNA-Targeted Sites and Their Correlations With Agronomic Traits in Rapeseed
Global Analysis of the Genetic Variations in miRNA-Targeted Sites and Their Correlations With Agronomic Traits in Rapeseed Open
MicroRNAs (miRNAs) and their target genes play vital roles in crops. However, the genetic variations in miRNA-targeted sites that affect miRNA cleavage efficiency and their correlations with agronomic traits in crops remain unexplored. On …
View article: Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction
Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction Open
Background: Islet dysfunction is the main pathological process of type 2 diabetes mellitus (T2DM). Fibrosis causes islet dysfunction, but the current mechanism is still unclear. Here, bioinformatics analysis identified gene clusters closel…
View article: A Pedigree and Clinical Analysis of 11β-Hydroxylase Deficiency with Homozygous Mutation of <i>CYP11B1</i> Gene
A Pedigree and Clinical Analysis of 11β-Hydroxylase Deficiency with Homozygous Mutation of <i>CYP11B1</i> Gene Open
Background To analyze the clinical features and the mutation of CYP11B1 gene in a family with 11β-hydroxylase deficiency. Methods The clinical and laboratory tests data of the patient were collected. The complete sequences of CYP11B1 gene …
View article: Composite cardiovascular risk and BMI affected comparative profiles of BIAsp 30 + metformin vs BIAsp 30 monotherapy: a MERIT post-hoc analysis
Composite cardiovascular risk and BMI affected comparative profiles of BIAsp 30 + metformin vs BIAsp 30 monotherapy: a MERIT post-hoc analysis Open
View article: Mining favorable alleles for five agronomic traits from the elite rapeseed cultivar Zhongshuang 11 by QTL mapping and integration
Mining favorable alleles for five agronomic traits from the elite rapeseed cultivar Zhongshuang 11 by QTL mapping and integration Open
View article: Tibet The Seed Germination Characteristics Under Low Temperature and Spring Sowing Study of 8 Rapeseed Varieties
Tibet The Seed Germination Characteristics Under Low Temperature and Spring Sowing Study of 8 Rapeseed Varieties Open
To explore the low temperature germination characteristics of rapeseed, 8 main cultivars were selected for germination experiments in incubators at 20℃, 16℃, 12℃ and 8℃, respectively, to measure and analyze the germination potential, germi…
View article: Pre-treatment Controlling Nutritional Status (CONUT) Score and Carcinoembryonic Antigen Level Provide Tumour Progression and Prognostic Information in Gastric Cancer ： A Retrospective Study
Pre-treatment Controlling Nutritional Status (CONUT) Score and Carcinoembryonic Antigen Level Provide Tumour Progression and Prognostic Information in Gastric Cancer ： A Retrospective Study Open
BackgroundThis study explores the role of combining the controlling nutritional status (CONUT) score and the carcinoembryonic antigen (CEA) level on predicting tumour stage and prognosis in gastric cancer (GC) patients.MethodsA total of 68…
View article: Molecular mechanisms underpinning the multiallelic inheritance of <i>MS5</i> in <i>Brassica napus</i>
Molecular mechanisms underpinning the multiallelic inheritance of <i>MS5</i> in <i>Brassica napus</i> Open
SUMMARY The Brassica ‐specific gene MS5 mediates early meiotic progression, and its allelic variants contribute to a valuable genic male sterility three‐line hybrid production system in rapeseed ( Brassica napus L.). However, the underlyin…
View article: Prognostic significance of high triglyceride and apolipoprotein B levels in patients with stage III and high-risk stage II colorectal cancer undergoing curative surgery
Prognostic significance of high triglyceride and apolipoprotein B levels in patients with stage III and high-risk stage II colorectal cancer undergoing curative surgery Open
Although epidemiologic studies suggest that dyslipidemia increases the risk of colorectal cancer (CRC), the prognostic value of blood lipid and apolipoprotein levels in CRC remains unclear. The aim of the present study was to investigate t…
View article: Breeding dominant genic male sterility restorer line of Brassica napus L.
Breeding dominant genic male sterility restorer line of Brassica napus L. Open
To facilate breeding process of Brassica napus, a microspore culture and molecular marker-assisted screening combined system were proposed in this research. At early flowering stage, F1 offspring of hybridized combination HY15A × HF06 wa…
View article: Exendin‑4 inhibits lipotoxicity‑induced oxidative stress in β‑cells by inhibiting the activation of TLR4/NF‑κB signaling pathway
Exendin‑4 inhibits lipotoxicity‑induced oxidative stress in β‑cells by inhibiting the activation of TLR4/NF‑κB signaling pathway Open
The present study aimed to investigate the relationship between the protective effects of exendin‑4 (EX‑4) on lipotoxicity‑induced oxidative stress and meta‑inflammation in β‑cells and the toll‑like receptor 4 (TLR4)/NF‑κB signaling pathwa…
View article: TAK-875 Mitigates <i>β</i>-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-<i>κ</i>B Pathway
TAK-875 Mitigates <i>β</i>-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-<i>κ</i>B Pathway Open
Metabolic inflammatory damage, characterized by Toll-like receptor 4 (TLR4) signaling activation, is a major mechanism underlying lipotoxicity-induced β -cell damage. The present study is aimed at determining whether G protein-coupled rece…
View article: Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in <i>β</i>-Cells through the Activation of GPR40-PLC-IP3 Pathway
Metformin Reduces Lipotoxicity-Induced Meta-Inflammation in <i>β</i>-Cells through the Activation of GPR40-PLC-IP3 Pathway Open
Background and Purpose . Metformin, a widely used antidiabetic drug, has been shown to have anti-inflammatory properties; nevertheless, its influence on β -cell meta-inflammation remains unclear. The following study investigated the effect…
View article: Glucagon-like peptide-1 receptor pathway inhibits extracellular matrix production by mesangial cells through store-operated Ca<sup>2+</sup>channel
Glucagon-like peptide-1 receptor pathway inhibits extracellular matrix production by mesangial cells through store-operated Ca<sup>2+</sup>channel Open
Glomerular mesangial cell is the major source of mesangial matrix. Our previous study demonstrated that store-operated Ca 2+ channel signaling suppressed extracellular matrix protein production by mesangial cells. Recent studies demonstrat…
View article: Observational study evaluating the effectiveness of physician‐targeted education for improving glycemic management of patients with type 2 diabetes (BEYOND II)
Observational study evaluating the effectiveness of physician‐targeted education for improving glycemic management of patients with type 2 diabetes (BEYOND II) Open
Background Because there has been no quality improvement initiatives targeting patients with type 2 diabetes (T2D) receiving basal insulin therapy, this study evaluated the effectiveness of physician‐targeted education for optimizing glyce…
View article: Identification of key genes involved in type 2 diabetic islet dysfunction: a bioinformatics study
Identification of key genes involved in type 2 diabetic islet dysfunction: a bioinformatics study Open
Aims: To identify the key differentially expressed genes (DEGs) in islet and investigate their potential pathway in the molecular process of type 2 diabetes. Methods: Gene Expression Omnibus (GEO) datasets (GSE20966, GSE25724, GSE38642) of…
View article: Standards of medical care for type 2 diabetes in China 2019
Standards of medical care for type 2 diabetes in China 2019 Open
Summary The prevalence of diabetes in China has increased rapidly from 0.67% in 1980 to 10.4% in 2013, with the aging of the population and westernization of lifestyle. Since its foundation in 1991, the Chinese Diabetes Society (CDS) has b…
View article: Chinese clinical guidelines for continuous glucose monitoring (2018 edition)
Chinese clinical guidelines for continuous glucose monitoring (2018 edition) Open
Summary Blood glucose monitoring is an important part of diabetes management. Continuous glucose monitoring (CGM) technology has become an effective complement to conventional blood glucose monitoring methods and has been widely applied in…