Liyu He
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View article: PUM2 Lowers HDAC9 mRNA Stability to Improve Contrast-Induced Acute Kidney Injury through Attenuating Oxidative Stress and Promoting Autophagy
PUM2 Lowers HDAC9 mRNA Stability to Improve Contrast-Induced Acute Kidney Injury through Attenuating Oxidative Stress and Promoting Autophagy Open
PUM2 overexpression suppressed oxidative stress and promoted autophagy to alleviate renal injury in DM-CIAKI through interacting with HDAC9 mRNA, which mediated degradation of HDAC9 mRNA and inhibition of HDAC9 expression.
View article: Bidirectional Cortical Gyrification Alterations in Chronic Obstructive Pulmonary Disease: Links to Cognitive Impairment and Global Initiative for Chronic Obstructive Lung Disease Staging
Bidirectional Cortical Gyrification Alterations in Chronic Obstructive Pulmonary Disease: Links to Cognitive Impairment and Global Initiative for Chronic Obstructive Lung Disease Staging Open
Purpose Cognitive impairment is a common but poorly understood comorbidity in chronic obstructive pulmonary disease. Although gray matter abnormalities have been observed in this population, the contribution of cortical gyrification—a stru…
View article: Deep learning for the prediction of acute kidney injury after coronary angiography and intervention in patients with chronic kidney disease: a model development and validation study
Deep learning for the prediction of acute kidney injury after coronary angiography and intervention in patients with chronic kidney disease: a model development and validation study Open
The explainable DNN models serve as promising tools for predicting PC-AKI in CKD patients undergoing coronary angiography and intervention, which is crucial for risk stratification and clinical descion-making.
View article: Efficacy and Safety of Telitacicept in IgA Nephropathy: A Retrospective, Multicenter Study
Efficacy and Safety of Telitacicept in IgA Nephropathy: A Retrospective, Multicenter Study Open
Introduction: The efficacy of telitacicept treatment in reducing proteinuria in patients with IgA nephropathy (IgAN) was indicated in a phase II clinical trial with small sample size. In this study, we conducted a large multicenter retrosp…
View article: Regulatory role of the mTOR signaling pathway in autophagy and mesangial proliferation in IgA nephropathy.
Regulatory role of the mTOR signaling pathway in autophagy and mesangial proliferation in IgA nephropathy. Open
Inhibition of the mTOR signaling pathway enhances renal autophagy, reduces mesangial cell proliferation, and improves renal injury in IgAN.
View article: Global, regional, and national levels and trends in burden of urticaria: A systematic analysis for the Global Burden of Disease study 2019
Global, regional, and national levels and trends in burden of urticaria: A systematic analysis for the Global Burden of Disease study 2019 Open
This study found that the global burden of urticaria has risen from 1990 to 2019. Factors like geographic location, gender, and SDI influenced the urticaria burden. Overall, these results offer a resource to guide public health strategies …
View article: HRCT findings predict 1-year mortality in patients with acute exacerbation of idiopathic inflammatory myopathies-associated interstitial lung disease
HRCT findings predict 1-year mortality in patients with acute exacerbation of idiopathic inflammatory myopathies-associated interstitial lung disease Open
HRCT findings, including TIDE, distribution pattern, and radiological pattern, are predictive of 1-year mortality in patients who experience AE-IIM-ILD.
View article: Compound Fault Diagnosis of Planetary Gearbox Based on Improved LTSS-BoW Model and Capsule Network
Compound Fault Diagnosis of Planetary Gearbox Based on Improved LTSS-BoW Model and Capsule Network Open
The identification of compound fault components of a planetary gearbox is especially important for keeping the mechanical equipment working safely. However, the recognition performance of existing deep learning-based methods is limited by …
View article: Global, regional, and national levels and trends in burden of urticaria: a systematic analysis for the global burden of disease 2019 study
Global, regional, and national levels and trends in burden of urticaria: a systematic analysis for the global burden of disease 2019 study Open
Background Urticaria causes a significant burden on individuals and society due to its pervasiveness. The aim of this study was to evaluate the burden of urticaria in different regions and nations by analyzing data from the Global Burden o…
View article: Single-cell transcriptomic analysis reveals transcript enrichment in oxidative phosphorylation, fluid sheer stress, and inflammatory pathways in obesity-related glomerulopathy
Single-cell transcriptomic analysis reveals transcript enrichment in oxidative phosphorylation, fluid sheer stress, and inflammatory pathways in obesity-related glomerulopathy Open
Obesity-related glomerulopathy (ORG) is an independent risk factor for chronic kidney disease and even progression to end-stage renal disease. Efforts have been undertaken to elucidate the mechanisms underlying the development of ORG and s…
View article: Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy
Targeting Renal Proximal Tubule Cells in Obesity-Related Glomerulopathy Open
As a metabolic disorder, obesity can cause secondary kidney damage, which is called obesity-related glomerulopathy (ORG). As the incidence of obesity increases worldwide, so does the incidence of end-stage renal disease (ESRD) caused by OR…
View article: Biopolymer-Based Nanosystems: Potential Novel Carriers for Kidney Drug Delivery
Biopolymer-Based Nanosystems: Potential Novel Carriers for Kidney Drug Delivery Open
Kidney disease has become a serious public health problem throughout the world, and its treatment and management constitute a huge global economic burden. Currently, the main clinical treatments are not sufficient to cure kidney diseases. …
View article: Bowman’s capsule rupture and the Oxford MEST-C score in adult patients with Immunoglobulin a vasculitis nephritis: a single center experience
Bowman’s capsule rupture and the Oxford MEST-C score in adult patients with Immunoglobulin a vasculitis nephritis: a single center experience Open
Bowman’s capsule rupture (BCR) is a glomerular pathological change, but it is still not well recognized in immunoglobulin A vasculitis nephritis (IgAV-N). The Oxford MEST-C score is a classification for IgA nephropathy; however, its clinic…
View article: DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity
DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity Open
Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy and play key roles in the development of diabetic nephropathy (DN). DsbA-L is mainly located in MAMs and plays a role in renoprot…
View article: 4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling
4-Octyl itaconate attenuates LPS-induced acute kidney injury by activating Nrf2 and inhibiting STAT3 signaling Open
Background Septic acute kidney injury (S-AKI) is the leading form of acute kidney failure among hospitalized patients, and the inflammatory response is involved in this process. 4-octyl itaconate (4-OI) is a multi-target itaconate derivati…
View article: Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease
Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease Open
Diabetic kidney disease (DKD) is the main complication in diabetes mellitus (DM) and the main cause of end-stage kidney disease worldwide. However, sodium glucose cotransporter 2 (SGLT2) inhibition, glucagon-like peptide-1 (GLP-1) receptor…
View article: Efficacy and indications of tonsillectomy in patients with IgA nephropathy: a retrospective study
Efficacy and indications of tonsillectomy in patients with IgA nephropathy: a retrospective study Open
Background The efficacy and indications of tonsillectomy in IgA nephropathy (IgAN) remain uncertain. Methods We performed a retrospective cohort study of 452 patients with primary IgAN, including 226 patients who received tonsillectomy and…
View article: Peer Review #2 of "Efficacy and indications of tonsillectomy in patients with IgA nephropathy: a retrospective study (v0.1)"
Peer Review #2 of "Efficacy and indications of tonsillectomy in patients with IgA nephropathy: a retrospective study (v0.1)" Open
Background.The efficacy and indications of tonsillectomy in IgA nephropathy (IgAN) remain uncertain.Methods.We performed a retrospective cohort study of 452 patients with primary IgAN, including 226 patients who received tonsillectomy and …
View article: Renal Proximal Tubular Cells: A New Site for Targeted Delivery Therapy of Diabetic Kidney Disease
Renal Proximal Tubular Cells: A New Site for Targeted Delivery Therapy of Diabetic Kidney Disease Open
Diabetic kidney disease (DKD) is a major complication of diabetes mellitus (DM) and the leading cause of end-stage kidney disease (ESKD) worldwide. A significant number of drugs have been clinically investigated for the treatment of DKD. H…
View article: Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy
Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy Open
Diabetic nephropathy (DN) involves serious lipid metabolism disorder, and renal ectopic lipid deposition aggravates DN progression. However, the molecular mechanism of renal lipid deposition in DN remains unclear. Lipid droplets (LDs) are …
View article: Myokines: Novel therapeutic targets for diabetic nephropathy
Myokines: Novel therapeutic targets for diabetic nephropathy Open
With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role …
View article: Bone-kidney axis: A potential therapeutic target for diabetic nephropathy
Bone-kidney axis: A potential therapeutic target for diabetic nephropathy Open
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). However, its pathogenesis remains unclear, and effective prevention and treatment strategies are lacking. Recently, organ-to-organ communication has become a…
View article: Intermittent Fasting—A Healthy Dietary Pattern for Diabetic Nephropathy
Intermittent Fasting—A Healthy Dietary Pattern for Diabetic Nephropathy Open
Diabetic nephropathy (DN), a metabolic disease, is characterized by severe systemic metabolic disorders. A unique dietary pattern, such as intermittent fasting (IF) has shown promising protective effects on various metabolic diseases, such…
View article: WITHDRAWN: HDAC9 promotes the susceptibility of diabetes to Contrast-induced acute kidney injury by regulating TXNIP/Trx1 pathway
WITHDRAWN: HDAC9 promotes the susceptibility of diabetes to Contrast-induced acute kidney injury by regulating TXNIP/Trx1 pathway Open
Background Contrast-induced acute kidney injury (CIAKI) is the third most common cause of hospital-acquired acute kidney injury. Diabetes mellitus (DM) is a major risk factor for CIAKI. Nevertheless, the mechanism of its role in diabetes s…
View article: LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy
LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy Open
Background Diabetic nephropathy (DN) is a serious complication among patients with diabetes. Elucidating its pathogenesis is crucial for identifying novel biomarkers and therapeutic targets for DN. Methods DN tissues were harvested for exa…
View article: LncRNA MALAT1 aggravates high glucose-induced renal tubular epithelial injury via activating LIN28A and the Nox4/AMPK/mTOR signaling axis
LncRNA MALAT1 aggravates high glucose-induced renal tubular epithelial injury via activating LIN28A and the Nox4/AMPK/mTOR signaling axis Open
Background Diabetic nephropathy (DN) is a serious complication among patients with diabetes. Elucidating its pathogenesis is crucial for identifying novel biomarkers and therapeutic targets for DN. Methods DN tissues were harvested for exa…