Explanipedia

ENDOU is potentially a robust diagnostic and prognostic biomarker in oral squamous cell carcinoma Open

Karolin Dahlgren, Blanka Kołodziej, Helena Hermelin, Carolin Maria Dahlström, Liza Löf , et al. · 2025

Background Oral squamous cell carcinoma (OSCC) is responsible for approximately 190,000 deaths each year worldwide, primarily due to late-stage diagnosis. The lack of clinically useful biomarkers has been identified as one of the crucial f…

Spatial mapping of proteins and their activity states in cancer models by multiplex in situ PLA Open

Liza Löf, Bo Xu, Tanay Kumar Sinha, Caroline Dahlström, Tanay Kumar Sinha , et al. · 2025

Improved methods are needed to gain insights in how proteins exert their myriad roles in cells and organs. Multiplex in situ proximity ligation assay (misPLA), described herein, can provide a window into the functional states of proteins i…

Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA) Open

Mengqi Wang, Masood Kamali‐Moghaddam, Liza Löf, Matilde Cortabarría Fernandez, Roger Díaz Codina , et al. · 2024

Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles Open

Ehsan Manouchehri Doulabi, Louise Dubois, Liza Löf, Tanay Kumar Sinha, George Mickhael Harinck , et al. · 2024

Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays Open

Ehsan Manouchehri Doulabi, Claudia Fredolini, R Gallini, Liza Löf, Qiujin Shen , et al. · 2022

Detection of SARS-CoV-2 antibodies in serum and dried blood spot samples of vaccinated individuals using a sensitive homogeneous proximity extension assay Open

Hongxing Zhao, Mengqi Wang, Phathutshedzo M. Muthelo, Liza Löf, Fredrik Sterky , et al. · 2022

A homogeneous PCR-based assay for sensitive and specific detection of antibodies in serum or dried blood spots (DBS) is presented and the method is used to monitor individuals infected with or vaccinated against SARS-CoV-2. Detection probe…

Monitoring drug–target interactions through target engagement-mediated amplification on arrays and <i>in situ</i> Open

Rasel A. Al-Amin, Lars Johansson, Eldar Abdurakhmanov, Nils Landegren, Liza Löf , et al. · 2022

Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolu…

Mitochondrial Respiration-Dependent ANT2-UCP2 Interaction Open

Tomas A. Schiffer, Liza Löf, R Gallini, Masood Kamali‐Moghaddam, Mattias Carlström , et al. · 2022

Adenine nucleotide translocases (ANTs) and uncoupling proteins (UCPs) are known to facilitate proton leak across the inner mitochondrial membrane. However, it remains to be unravelled whether UCP2/3 contribute to significant amount of prot…

Checkpoint <span>CD47</span> expression in classical Hodgkin lymphoma Open

Alex Reza Gholiha, Peter Hollander, Liza Löf, Ingrid Glimelius, Gustaf Hedström , et al. · 2022

Summary The glycoprotein CD47 regulates antiphagocytic activity via signal regulatory protein alpha (SIRPa). This study investigated CD47 expression on Hodgkin and Reed–Sternberg (HRS) cells in the classical Hodgkin lymphoma (cHL) tumour m…

Immune-Proteome Profiling in Classical Hodgkin Lymphoma Tumor Diagnostic Tissue Open

Alex Reza Gholiha, Peter Hollander, Liza Löf, Anders Larsson, Jamileh Hashemi , et al. · 2021

In classical Hodgkin Lymphoma (cHL), immunoediting via protein signaling is key to evading tumor surveillance. We aimed to identify immune-related proteins that distinguish diagnostic cHL tissues (=diagnostic tumor lysates, n = 27) from co…

Monitoring Drug-Target Interactions through Target Engagement-Mediated Amplification on Arrays and in situ Open

Rasel A. Al-Amin, Lars Johansson, Eldar Abdurakhmanov, Nils Landegren, Liza Löf , et al. · 2021

Drugs are designed to bind their target proteins in physiologically relevant tissues and organs to modulate biological functions and elicit desirable clinical outcomes. Information about target engagement at cellular and subcellular resolu…

Human proteins incorporated into tick-borne encephalitis virus revealed by in situ proximity ligation Open

Ryoyo Ikebuchi, Alfred W. Isaac, Kentaro Yoshii, Ehsan Manouchehri Doulabi, Liza Löf , et al. · 2020

Human erythrocyte-derived nanovesicles can readily be loaded with doxorubicin and act as anticancer agents. Open

Louise Dubois, Liza Löf, Anders Larsson, Kjell Hultenby, Anders Waldenström , et al. · 2018

Purpose: In future therapeutics new formulas are needed that assure lower doses, fewer side effects, targeted administration and protection of the drug from degradation. In a first step to fulfil the requirements defined above, we carried …

KIT signaling is dispensable for human mast cell progenitor development Open

Joakim S. Dahlin, Maria Ekoff, Jennine Grootens, Liza Löf, Rose‐Marie Amini , et al. · 2017

Key Points SCF and KIT signaling are dispensable for the survival, proliferation, and maturation of human mast cell progenitors.

Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays Open

Pia Larssen, Lotta Wik, Paulo Czarnewski, Maria Eldh, Liza Löf , et al. · 2017

There were two typographical errors in this article. In Table II, the heading for columns 2 and 3 were switched. On page 506, the sentence "As above, proteins shared between cell lysates and exosomes were removed using ComBat" should read …

Analytically Sensitive Protein Detection in Microtiter Plates by Proximity Ligation with Rolling Circle Amplification Open

Tonge Ebai, Felipe Marques Souza de Oliveira, Liza Löf, Lotta Wik, Caroline Schweiger , et al. · 2017

BACKGROUND Detecting proteins at low concentrations in plasma is crucial for early diagnosis. Current techniques in clinical routine, such as sandwich ELISA, provide sensitive protein detection because of a dependence on target recognition…

Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia Open

Liza Löf, Linda Arngården, Ulla Olsson‐Strömberg, Benjamin Siart, Mattias Jansson , et al. · 2017

Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays Open

Pia Larssen, Lotta Wik, Paulo Czarnewski, Maria Eldh, Liza Löf , et al. · 2017

Detecting individual extracellular vesicles using a multicolor in situ proximity ligation assay with flow cytometric readout Open

Liza Löf, Tonge Ebai, Louise Dubois, Lotta Wik, G. Ronquist , et al. · 2016

Flow cytometry is a powerful method for quantitative and qualitative analysis of individual cells. However, flow cytometric analysis of extracellular vesicles (EVs) and the proteins present on their surfaces has been hampered by the small …

Applications of in situ proximity ligation assays for cancer research and diagnostics Open

Liza Löf · 2016

In the field of cancer research and diagnostics it is crucial to have reliable methods for detecting molecules involved in the disease. New and better methods for diagnostics, prognostics and drug delivery therefore remain a permanent aim.…

Proximity-dependent initiation of hybridization chain reaction Open

Björn Koos, Gaëlle Cane, Karin Grannas, Liza Löf, Linda Arngården , et al. · 2015

Pla Flow; A Flow Cytometry-Based Assay For Detection Of Bcr-Abl Fusion Protein In Blood Cells From Cml Patients Open

Liza Löf, Ulla Olsson‐Strömberg, Ulf Landegren, Masood Kamali‐Moghaddam · 2015

Pla Flow; A Flow Cytometry-Based Assay For Detection Of Bcr-Abl Fusion Protein In Blood Cells From Cml Patients

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