Lizhang Chen
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View article: Interaction Between First-Trimester Energy-Adjusted Dietary Inflammatory Index and Educational Level on the Risk of Anemia During the Second and Third Trimesters: A Prospective Cohort Study
Interaction Between First-Trimester Energy-Adjusted Dietary Inflammatory Index and Educational Level on the Risk of Anemia During the Second and Third Trimesters: A Prospective Cohort Study Open
Objectives: The aim of this cohort study was to assess the associations of first-trimester energy-adjusted Dietary Inflammatory Index (E-DII) and maternal educational level with anemia during the second and third trimesters, as well as the…
View article: Global, regional, and national time trends in disability-adjusted life years for neonatal preterm birth, from 1992 to 2021: an age-period-cohort analysis for the global burden of disease study 2021
Global, regional, and national time trends in disability-adjusted life years for neonatal preterm birth, from 1992 to 2021: an age-period-cohort analysis for the global burden of disease study 2021 Open
Background Neonatal preterm birth emerges as a leading cause of neonatal mortality and morbidity. Although there is a growing recognition of the urgent need to address the global health challenges posed by neonatal preterm birth, the under…
View article: Global, regional, and national time trends in prevalence of metabolic dysfunction associated steatotic liver disease among women of reproductive age: an age-period-cohort analysis for the global Burden of Disease 2021 study
Global, regional, and national time trends in prevalence of metabolic dysfunction associated steatotic liver disease among women of reproductive age: an age-period-cohort analysis for the global Burden of Disease 2021 study Open
MASLD in the WRA is an increasing health problem in all countries, and is accompanied by worsening period and cohort risks. These population-level trends warrant further investigation of their clinical implications for maternal health outc…
View article: Time trends in subarachnoid haemorrhage mortality across the BRICS (Brazil, Russian Federation, India, China and South Africa): an age-period-cohort analysis for the GBD 2021
Time trends in subarachnoid haemorrhage mortality across the BRICS (Brazil, Russian Federation, India, China and South Africa): an age-period-cohort analysis for the GBD 2021 Open
Objectives Subarachnoid haemorrhage (SAH) is the third most prevalent subtype of stroke, representing a critical and potentially life-threatening cerebrovascular emergency. Given their large populations and diverse healthcare infrastructur…
View article: Improving Adaptive Moment Optimization via Preconditioner Diagonalization
Improving Adaptive Moment Optimization via Preconditioner Diagonalization Open
Modern adaptive optimization methods, such as Adam and its variants, have emerged as the most widely used tools in deep learning over recent years. These algorithms offer automatic mechanisms for dynamically adjusting the update step based…
View article: Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis
Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis Open
Background Gynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. These cancers pose a significant threat to women’s health, impacting life expectancy, quality of life, and fertili…
View article: Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study
Immunocytes Mediate the Effects of Gut Microbiome on Inflammatory Bowel Disease: Insights From a Mendelian Randomization Study Open
Observational evidence suggests a complex link between gut microbiota and inflammatory bowel disease (IBD). However, the mechanisms underlying this relationship remain unclear. The present Mendelian randomization (MR) study aims to examine…
View article: Global, regional, and national time trends in incidence for depressive disorders, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019
Global, regional, and national time trends in incidence for depressive disorders, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019 Open
Our current findings reflect substantial health disparities and potential priority-setting of depressive disorders incidence in the three dimensions of age, period and cohort across SDI regions, countries. The scope of healthcare to improv…
View article: Association between the Maternal Gut Microbiome and Macrosomia
Association between the Maternal Gut Microbiome and Macrosomia Open
Fetal macrosomia is defined as a birthweight ≥4000 g and causes harm to pregnant women and fetuses. Studies reported that the maternal intestinal microbiome plays a key role in the establishment, growth, and development of the fetal intest…
View article: Memory-Efficient Optimization with Factorized Hamiltonian Descent
Memory-Efficient Optimization with Factorized Hamiltonian Descent Open
Modern deep learning heavily depends on adaptive optimizers such as Adam and its variants, which are renowned for their capacity to handle model scaling and streamline hyperparameter tuning. However, these algorithms typically experience h…
View article: Impact of <i>PD-L1</i> Gene Polymorphisms and Interactions with Cooking with Solid Fuel Exposure on Tuberculosis
Impact of <i>PD-L1</i> Gene Polymorphisms and Interactions with Cooking with Solid Fuel Exposure on Tuberculosis Open
Introduction: Given that PD-L1 is a crucial immune checkpoint in regulating T-cell responses, the aim of this study was to explore the impact of PD-L1 gene polymorphisms and the interaction with cooking with solid fuel on susceptibility to…
View article: Shared genetic architecture and causal relationship between the age at first sex and COVID-19: A large-scale cross-trait analysis
Shared genetic architecture and causal relationship between the age at first sex and COVID-19: A large-scale cross-trait analysis Open
COVID-19 is genetically associated with numerous immune disorders, and young age at first intercourse (AFS) may lead to early activation of innate immunity. However, the genetic overlap between COVID-19 and AFS remains undetermined. Here w…
View article: Hypotension and cognitive impairment among the elderly: Evidence from the CLHLS
Hypotension and cognitive impairment among the elderly: Evidence from the CLHLS Open
Background While high blood pressure has been linked to cognitive impairment, the relationship between low blood pressure, especially hypotension, and cognitive impairment has not been well studied. Therefore, this study aimed to assess th…
View article: Global, regional, and national time trends in incidence for migraine, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019
Global, regional, and national time trends in incidence for migraine, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019 Open
Background The majority of epidemiological studies on migraine have been conducted in a specific country or region, and there is a lack of globally comparable data. We aim to report the latest information on global migraine incidence overv…
View article: Time trends in cardiovascular disease mortality attributable to non-optimal temperatures in China: An age-period-cohort analysis using the Global Burden of Disease Study 2019
Time trends in cardiovascular disease mortality attributable to non-optimal temperatures in China: An age-period-cohort analysis using the Global Burden of Disease Study 2019 Open
Background Associations between non-optimal temperatures and cardiovascular disease (CVD) mortality risk have been previously reported, yet the trends of CVD mortality attributable to non-optimal temperatures remain unclear in China. We an…
View article: Maternal Body Mass Index, Gestational Weight Gain, and Risk of Cancer in Offspring: A Systematic Review and Meta-Analysis
Maternal Body Mass Index, Gestational Weight Gain, and Risk of Cancer in Offspring: A Systematic Review and Meta-Analysis Open
Background: Mounting evidence suggests that maternal obesity and gestational weight gain (GWG) may increase the risk of cancer in their offspring; however, results are inconsistent. The purpose of this research is to determine the associat…
View article: Disease burden and attributable risk factors of neonatal disorders and their specific causes in China from 1990 to 2019 and its prediction to 2024
Disease burden and attributable risk factors of neonatal disorders and their specific causes in China from 1990 to 2019 and its prediction to 2024 Open
Background Neonatal health is a cornerstone for the healthy development of the next generation and a driving force for the progress of population and society in the future. Updated information on the burden of neonatal disorders (NDs) are …
View article: Serum microcystin-LR levels and risk of gestational diabetes mellitus: A Chinese nested case-control study
Serum microcystin-LR levels and risk of gestational diabetes mellitus: A Chinese nested case-control study Open
Background Previous experimental studies have reported an association between microcystin-LR (MC-LR) and glucose homeostasis, but whether exposure to MC-LR is a risk factor for the pathogenesis of gestational diabetes mellitus (GDM) requir…
View article: Polymorphisms in <i>PI3K/AKT</i> genes and gene‑smoking interaction are associated with susceptibility to tuberculosis
Polymorphisms in <i>PI3K/AKT</i> genes and gene‑smoking interaction are associated with susceptibility to tuberculosis Open
Phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) are involved in the clearance of Mycobacterium tuberculosis (MTB) by macrophages. This study aimed to investigate the effects of polymorphisms in the PI3K/AKT genes and the ge…
View article: Additional file 2 of Disease burden and attributable risk factors of neonatal disorders and their specific causes in China from 1990 to 2019 and its prediction to 2024
Additional file 2 of Disease burden and attributable risk factors of neonatal disorders and their specific causes in China from 1990 to 2019 and its prediction to 2024 Open
Additional file 2.
View article: Prognostic value of N-terminal pro-form B-type natriuretic peptide (NT-proBNP) in patients with congenital heart disease undergoing cardiac surgery: a systematic review and meta-analysis of cohort studies
Prognostic value of N-terminal pro-form B-type natriuretic peptide (NT-proBNP) in patients with congenital heart disease undergoing cardiac surgery: a systematic review and meta-analysis of cohort studies Open
Compared with CHD patients at low NT-proBNP levels, CHD patients at high NT-proBNP levels had elevated risks of mortality and cardiovascular events. Further large-scale and well-controlled studies are needed to confirm our findings.
View article: Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis
Association between dietary inflammatory index and oral cancer risk: A systematic review and dose–response meta-analysis Open
Background Dietary inflammatory index (DII) has been suggested to be associated with oral cancer risk. However, a quantitative comprehensive assessment of the dose–response relationship has not been reported. We performed a meta-analysis t…
View article: Effects of Maternal Pre-Pregnancy BMI and Gestational Weight Gain on the Development of Preeclampsia and Its Phenotypes: A Prospective Cohort Study in China
Effects of Maternal Pre-Pregnancy BMI and Gestational Weight Gain on the Development of Preeclampsia and Its Phenotypes: A Prospective Cohort Study in China Open
Preeclampsia (PE) is a common and serious pregnancy-specific disorder, which is closely linked with adverse maternal and neonatal outcomes. This study aimed to evaluate whether maternal pre-pregnancy body mass index (BMI) and gestational w…
View article: Time Trends in the Incidence of Spinal Pain in China, 1990 to 2019 and Its Prediction to 2030: The Global Burden of Disease Study 2019
Time Trends in the Incidence of Spinal Pain in China, 1990 to 2019 and Its Prediction to 2030: The Global Burden of Disease Study 2019 Open
Spinal pain has remained a major public health burden over the past 30 years in China and will likely increase further with population aging. Therefore, spinal pain should be a priority for future research on prevention and therapy, and is…
View article: Maternal pre-pregnancy/early-pregnancy smoking and risk of congenital heart diseases in offspring: A prospective cohort study in Central China
Maternal pre-pregnancy/early-pregnancy smoking and risk of congenital heart diseases in offspring: A prospective cohort study in Central China Open
Our findings add to the existing body of evidence that implicates maternal pre-pregnancy/early-pregnancy smoking as a significant risk factor for CHDs and their select phenotypes.
View article: Association between maternal gut microbiome and macrosomia
Association between maternal gut microbiome and macrosomia Open
Background: Fetal macrosomia is defined as birthweight≧4000g and causes harm to pregnant women and infants. Studies reported that maternal intestinal microbiome plays a key role in the establishment, growth and development of fetal intesti…
View article: Overweight/Obesity in Childhood and the Risk of Early Puberty: A Systematic Review and Meta-Analysis
Overweight/Obesity in Childhood and the Risk of Early Puberty: A Systematic Review and Meta-Analysis Open
Purpose To determine the relationship between childhood overweight/obesity and early puberty in both boys and girls. Specifically, this is the first time to conduct a meta-analysis of the relationship between childhood overweight/obesity a…
View article: Impact of PD-L1 gene polymorphism and its interaction with cooking with solid fuel exposure upon susceptibility to tuberculosis
Impact of PD-L1 gene polymorphism and its interaction with cooking with solid fuel exposure upon susceptibility to tuberculosis Open
Given that PD-L1 is a crucial immune checkpoint in regulating T cell responses, the aim of this study was to explore the impact of PD-L1 gene polymorphism and its interaction with cooking with solid fuel on susceptibility to tuberculosis (…
View article: Hypertensive Disorders in Pregnancy Are Associated With Congenital Heart Defects in Offspring: A Systematic Review and Meta-Analysis
Hypertensive Disorders in Pregnancy Are Associated With Congenital Heart Defects in Offspring: A Systematic Review and Meta-Analysis Open
Background Although research indicates an association between hypertensive disorders of pregnancy (HDP) and congenital heart defects (CHDs) in offspring, consistency is still lacking. Therefore, we aimed to synthesize the updated published…