Lizheng Qin
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View article: NLRP3 Mediates Submandibular Gland Regeneration in Duct Ligation/De‐Ligation Model
NLRP3 Mediates Submandibular Gland Regeneration in Duct Ligation/De‐Ligation Model Open
Objective The initial inflammatory response following tissue injury activates macrophages, which are essential for tissue regeneration. NLRP3 plays a crucial role in initiating this inflammatory response and is involved in tissue regenerat…
View article: Salivary Gland Ligation Inhibited The Antipyroptotic Effect Of Inorganic Nitrate
Salivary Gland Ligation Inhibited The Antipyroptotic Effect Of Inorganic Nitrate Open
Aim or purpose: The aim of this study is to determine the effect of salivary gland function on the anti-inflammatory and anti-pyroptotic effects of inorganic nitrate in collagen-induced arthritis (CIA). Materials and methods: The CIA model…
View article: Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration
Duct ligation/de-ligation model: exploring mechanisms for salivary gland injury and regeneration Open
Sialadenitis and sialadenitis-induced sialopathy are typically caused by obstruction of the salivary gland ducts. Atrophy of the salivary glands in experimental animals caused by duct ligation exhibits a histopathology similar to that of s…
View article: Case report: Rare oral manifestations in Cowden syndrome with PTEN mutation
Case report: Rare oral manifestations in Cowden syndrome with PTEN mutation Open
Background Cowden syndrome (CS) is a rare genetic disorder associated with PTEN gene mutations. It is characterized by macrocephaly, specific mucocutaneous features, and a predisposition to benign and malignant tumors. Cases of CS primaril…
View article: Targeted down-regulation of SRSF1 exerts anti-cancer activity in OSCC through impairing lysosomal function and autophagy
Targeted down-regulation of SRSF1 exerts anti-cancer activity in OSCC through impairing lysosomal function and autophagy Open
Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck. Despite ongoing efforts, there remains a dearth of targeted drugs capable of effectively inhibiting OSCC growth. As the earliest discovered proto-oncogene in the …
View article: Supplementary Figures 1 - 8 from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation
Supplementary Figures 1 - 8 from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation Open
PDF file - 2605K, Fig. S1. X-gal staining of SMG sections from Ptch1-lacZ mice non-treated (NT), 7 days after ligation of main excretory ducts or IR. Fig. S2. 7 days of Dox treatment did not rescue IR-induced hyposalivation in female Krtrt…
View article: Supplementary Figures 1 - 8 from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation
Supplementary Figures 1 - 8 from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation Open
PDF file - 2605K, Fig. S1. X-gal staining of SMG sections from Ptch1-lacZ mice non-treated (NT), 7 days after ligation of main excretory ducts or IR. Fig. S2. 7 days of Dox treatment did not rescue IR-induced hyposalivation in female Krtrt…
View article: Data from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation
Data from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation Open
Purpose: To examine the effects and mechanisms of transient activation of the Hedgehog pathway on rescuing radiotherapy-induced hyposalivation in survivors of head and neck cancer.Experimental Design: Mouse salivary glands an…
View article: Data from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation
Data from Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation Open
Purpose: To examine the effects and mechanisms of transient activation of the Hedgehog pathway on rescuing radiotherapy-induced hyposalivation in survivors of head and neck cancer.Experimental Design: Mouse salivary glands an…
View article: Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on swarm learning approach
Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on swarm learning approach Open
Inorganic nitrate is an indispensable nutrient that has been used in experimental studies for the prevention and treatment of several diseases. However, the short half-life of nitrate limits its clinical application. To increase the usabil…
View article: Targeted Down-Regulation of SRSF1 Exerts Anti-Cancer Activity in OSCC Through Impairing Lysosomal Function and Inducing Autophagy
Targeted Down-Regulation of SRSF1 Exerts Anti-Cancer Activity in OSCC Through Impairing Lysosomal Function and Inducing Autophagy Open
View article: Abnormal downregulation of 10‐formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating <scp>PI3K</scp>/Akt/Rb pathway
Abnormal downregulation of 10‐formyltetrahydrofolate dehydrogenase promotes the progression of oral squamous cell carcinoma by activating <span>PI3K</span>/Akt/Rb pathway Open
Background 10‐formyltetrahydrofolate dehydrogenase (ALDH1L1) is a major folate enzyme, which is usually underexpressed in malignant tumors and competes with tumors for the same folate substrate. However, the specific role and mechanisms of…
View article: Homeostatic medicine: a strategy for exploring health and disease
Homeostatic medicine: a strategy for exploring health and disease Open
Homeostasis is a process of dynamic balance regulated by organisms, through which they maintain an internal stability and adapt to the external environment for survival. In this paper, we propose the concept of utilizing homeostatic medici…
View article: Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on deep learning approach
Nanonitrator: novel enhancer of inorganic nitrate’s protective effects, predicated on deep learning approach Open
Inorganic nitrate is an indispensable nutrient, which has been used in experimental studies on the prevention and treatment of several diseases. However, its short half-life limits inorganic nitrate’s clinical application. To increase nitr…
View article: Protective roles of inorganic nitrate in health and diseases
Protective roles of inorganic nitrate in health and diseases Open
Various beneficial biological activities of inorganic nitrate have been revealed in recent decades. Oral bacteria can reduce nitrate to nitrite, which is further reduced to nitric oxide (NO) in the body; this process is known as the nitrat…
View article: Author response for "Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis"
Author response for "Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis" Open
View article: Author response for "ALDH3A1 overexpression in OSCC inhibits inflammation via phospho‐Ser727 at STAT3 in tumor‐associated macrophages"
Author response for "ALDH3A1 overexpression in OSCC inhibits inflammation via phospho‐Ser727 at STAT3 in tumor‐associated macrophages" Open
View article: Author response for "ALDH3A1 overexpression in OSCC inhibits inflammation via phospho‐Ser727 at STAT3 in tumor‐associated macrophages"
Author response for "ALDH3A1 overexpression in OSCC inhibits inflammation via phospho‐Ser727 at STAT3 in tumor‐associated macrophages" Open
View article: The intact parasympathetic nerve promotes submandibular gland regeneration through ductal cell proliferation
The intact parasympathetic nerve promotes submandibular gland regeneration through ductal cell proliferation Open
Objectives Salivary gland regeneration is closely related to the parasympathetic nerve; however, the mechanism behind this relationship is still unclear. The aim of this study was to evaluate the relationship between the parasympathetic ne…
View article: Knowledge of Chinese dentists on HPV, their willingness and barriers to recommend HPV vaccination to patients
Knowledge of Chinese dentists on HPV, their willingness and barriers to recommend HPV vaccination to patients Open
Objective: This study aimed to assess the knowledge of Chinese dentists on human papilloma virus (HPV), their willingness and factors prevention them from recommending patients for HPV vaccination, and to identify ways through which dentis…
View article: ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway
ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway Open
Objectives: Aldehyde dehydrogenase 3A1 (ALDH3A1) is a member of the ALDH superfamily and its relationship with oral squamous cell carcinoma (OSCC) still unknown. In our subject, we aimed to reveal the expression pattern and clinical…
View article: Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model
Intragland Shh gene delivery mitigated irradiation-induced hyposalivation in a miniature pig model Open
Irreversible hypofunction of salivary glands is common in head and neck cancer survivors treated with radiotherapy and can only be temporarily relieved with current treatments. We found recently in mouse models that transient activation of…
View article: Rescue Effects and Underlying Mechanisms of Intragland<i>Shh</i>Gene Delivery on Irradiation-Induced Hyposalivation
Rescue Effects and Underlying Mechanisms of Intragland<i>Shh</i>Gene Delivery on Irradiation-Induced Hyposalivation Open
Irreversible hypofunction of salivary glands is common in head and neck cancer survivors treated with radiotherapy and can only be temporarily relieved with current treatments. We found in an inducible sonic hedgehog (Shh) transgenic mouse…
View article: Histological characteristics following a long-term nitrate-rich diet in miniature pigs with parotid atrophy.
Histological characteristics following a long-term nitrate-rich diet in miniature pigs with parotid atrophy. Open
The aim of this study was to investigate the histological characteristics following a 2-year nitrate-rich diet in miniature pigs with parotid atrophy. Using averages collected data from three time points at 6, 12, and 24 months following t…