Li‐Ju Wang
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View article: High-Throughput Empirical and Virtual Screening To Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer
High-Throughput Empirical and Virtual Screening To Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer Open
Therapy resistance in breast cancer is increasingly attributed to polyploid giant cancer cells (PGCCs), which arise through whole genome doubling and exhibit heightened resilience to standard treatments. Characterized by enlarged nuclei an…
View article: High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer
High-Throughput Empirical and Virtual Screening to Discover Novel Inhibitors of Polyploid Giant Cancer Cells in Breast Cancer Open
Therapy resistance in breast cancer is increasingly attributed to polyploid giant cancer cells (PGCCs), which arise through whole-genome doubling and exhibit heightened resilience to standard treatments. Characterized by enlarged nuclei an…
View article: Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis
Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis Open
Background There is a lack of further exploration of the epileptogenic network of specific types of epilepsy, such as unilateral hippocampal sclerosis (HS), and there is an urgent need to find exact evidence to confirm the consistency of i…
View article: Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancer
Targeting S6K/NFκB/SQSTM1/Polθ signaling to suppress radiation resistance in prostate cancer Open
In this study we have identified POLθ-S6K-p62 as a novel druggable regulator of radiation response in prostate cancer. Despite significant advances in delivery, radiotherapy continues to negatively affect treatment outcomes and quality of …
View article: shinyDeepDR: A user-friendly R Shiny app for predicting anti-cancer drug response using deep learning
shinyDeepDR: A user-friendly R Shiny app for predicting anti-cancer drug response using deep learning Open
Advancing precision oncology requires accurate prediction of treatment response and accessible prediction models. To this end, we present shinyDeepDR, a user-friendly implementation of our innovative deep learning model, DeepDR, for predic…
View article: Sex-dependent differences in the genomic profile of lingual sensory neurons in naïve and tongue-tumor bearing mice
Sex-dependent differences in the genomic profile of lingual sensory neurons in naïve and tongue-tumor bearing mice Open
Mechanisms of sex-dependent orofacial pain are widely understudied. A significant gap in knowledge exists about comprehensive regulation of tissue-specific trigeminal sensory neurons in diseased state of both sexes. Using RNA sequencing of…
View article: CCDC 2163188: Experimental Crystal Structure Determination
CCDC 2163188: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: BRCA1 deficiency in mature CD8<sup>+</sup> T lymphocytes impairs antitumor immunity
BRCA1 deficiency in mature CD8<sup>+</sup> T lymphocytes impairs antitumor immunity Open
Women with BRCA1 germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in breast epithelium has been studied extensively, it is not clear whether BRCA1 defici…
View article: Sex-dependent Differences in the Genomic Profile of Lingual Sensory Neurons in Naïve and Tongue-Tumor Bearing Mice
Sex-dependent Differences in the Genomic Profile of Lingual Sensory Neurons in Naïve and Tongue-Tumor Bearing Mice Open
Mechanisms of sex-dependent orofacial pain are widely understudied. A significant gap in knowledge exists about comprehensive regulation of tissue-specific trigeminal sensory neurons in diseased state of both sexes. Using RNA sequencing of…
View article: DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer
DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer Open
Motivation Large-scale genetic and pharmacologic dependency maps are generated to reveal genetic vulnerabilities and drug sensitivities of cancer. However, user-friendly software is needed to systematically link such maps. Results Here, we…
View article: Quality evaluation of immunomodulatory polysaccharides from <i>Agaricus bisporus</i> by an integrated fingerprint technique
Quality evaluation of immunomodulatory polysaccharides from <i>Agaricus bisporus</i> by an integrated fingerprint technique Open
Agaricus bisporus ( A. bisporus ) is a rich source of polysaccharides with medical and nutraceutical interests; however, the complex structure of A. bisporus polysaccharides (ABPs) poses a challenge to its quality control. This study aims …
View article: DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer
DepLink: an R Shiny app to systematically link genetic and pharmacologic dependencies of cancer Open
Large-scale genetic and pharmacologic dependency maps are generated to reveal genetic vulnerabilities and drug sensitivities of cancer. However, user-friendly software is needed to systematically link such maps. Here we present DepLink, an…
View article: Comparative Transcriptome Analysis of Superficial and Deep Partial-Thickness Burn Wounds in Yorkshire vs Red Duroc Pigs
Comparative Transcriptome Analysis of Superficial and Deep Partial-Thickness Burn Wounds in Yorkshire vs Red Duroc Pigs Open
Hypertrophic scars are a common negative outcome of deep partial-thickness (DPT) burn wounds resulting in increased dermal thickness, wound area contracture, and inflammation of the affected area. The red Duroc and Yorkshire porcine breeds…
View article: Predicting and characterizing a cancer dependency map of tumors with deep learning
Predicting and characterizing a cancer dependency map of tumors with deep learning Open
A novel deep learning method links in vitro CRISPR screens to the context of cancer genomics and translates to individual tumors.
View article: Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling
Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling Open
The NAD+-dependent deacetylase, Sirtuin 1 (SIRT1) is involved in prostate cancer pathogenesis. However, the actual contribution is unclear as some reports propose a protective role while others suggest it is harmful. We provide evidence fo…
View article: Antibiotic Administration Routes and Oral Exposure to Antibiotic Resistant Bacteria as Key Drivers for Gut Microbiota Disruption and Resistome in Poultry
Antibiotic Administration Routes and Oral Exposure to Antibiotic Resistant Bacteria as Key Drivers for Gut Microbiota Disruption and Resistome in Poultry Open
Previous studies have identified oral administration of antibiotics and gut-impacting drugs as critical drivers for fecal antibiotic resistance (AR) and microbiome disruption in lab mice, but the practical implications of these findings ha…
View article: An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data
An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data Open
Background Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. Therefore, the genetic admixture may cause…
View article: An ancestral informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data
An ancestral informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data Open
Background Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. In those ancestral groups, it has markedly different incidence rates and outcomes in many types of cancers. Therefore, the genetic admixture may…
View article: MOESM3 of An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data
MOESM3 of An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data Open
Additional file 3: Table S3. The ancestral proportions and clinical data of TCGA-LIHC samples (S3A: tumor DNAs; S3B: normal DNAs).
View article: MOESM1 of An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data
MOESM1 of An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data Open
Additional file 1: Table S1. Informativeness of AIMs across different panels.
View article: MOESM2 of An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data
MOESM2 of An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data Open
Additional file 2: Table S2. Informativeness of AIMs of the UT-AIM250 panel.
View article: Predicting drug response of tumors from integrated genomic profiles by deep neural networks
Predicting drug response of tumors from integrated genomic profiles by deep neural networks Open
The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response. A recent screening of ~1,000 cancer cell lines to a collection of ant…
View article: Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer
Genome-wide identification of key modulators of gene-gene interaction networks in breast cancer Open
Here we present, as far as we know, the first comprehensive analysis of key modulator genes on a genome-wide scale. The validity of filtering parameters as well as the conservativity of modulators among cohorts were corroborated. Our data …
View article: Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival
Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival Open
This work addresses the lack of a comprehensive exploration into the functional and prognostic relevance of ceRNA interaction in GBM. The proposed efficient and reliable method revealed its significance in GBM-related functions and prognos…