Steven G. Lloyd
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View article: Imminent risk of LVEF decline in asymptomatic patients with primary mitral regurgitation
Imminent risk of LVEF decline in asymptomatic patients with primary mitral regurgitation Open
Background 2020 American College of Cardiology/American Heart Association (ACC/AHA) Guidelines state that the ideal time for mitral valve surgery in primary mitral regurgitation (PMR) is when the LV approaches but has not yet reached echoc…
View article: Non-invasively measured myocardial torsional modulus: Comparison to invasive evaluation of diastolic function
Non-invasively measured myocardial torsional modulus: Comparison to invasive evaluation of diastolic function Open
We propose a new method to objectively evaluate diastolic relaxation properties of the LV. This method may have promise to replace invasive, catheter-based assessment of diastolic function.
View article: Adverse cardiac remodeling is absent in patients with true controlled resistant hypertension
Adverse cardiac remodeling is absent in patients with true controlled resistant hypertension Open
Resistant hypertension (RHTN), defined as blood pressure (BP) that is uncontrolled with ≥3 medications, including a long‐acting thiazide diuretic, also includes a subset with BP that is controlled with ≥4 medications, so‐called controlled …
View article: Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis
Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis Open
After an incubation period of weeks to months, up to 14% of cats infected with feline coronavirus (FCoV) develop feline infectious peritonitis (FIP): a potentially lethal pyogranulomatous perivasculitis. The aim of this study was to find o…
View article: Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis
Stopping Feline Coronavirus Shedding Prevented Feline Infectious Peritonitis Open
After an incubation period of weeks to months up to 14% of cats infected with feline coronavirus (FCoV) develop feline infectious peritonitis (FIP): a potentially lethal pyogranulomatous perivasculitis. The aim of this study was to find ou…
View article: Impact of Virtual Interviewing on Geographic Placement for Cardiology Fellowship Recruitment
Impact of Virtual Interviewing on Geographic Placement for Cardiology Fellowship Recruitment Open
Background Virtual interviewing for cardiology fellowship was instituted in the 2021 fellowship application cycle because of the COVID‐19 pandemic and restricted travel. The impact on geographic patterns of fellow‐training program matching…
View article: Aerosol property retrievals with the use of an airborne compact multi-angle polarimeter (C-MAP)
Aerosol property retrievals with the use of an airborne compact multi-angle polarimeter (C-MAP) Open
<p>Atmospheric aerosol particles originating either from natural (i.e. dust, volcanic ash, smoke, sea salt) or anthropogenic (i.e. pollution, agricultural activities) sources, affect the Earth&#8217;s climate through absorption a…
View article: Diastolic function: modeling left ventricular untwisting as a damped harmonic oscillator
Diastolic function: modeling left ventricular untwisting as a damped harmonic oscillator Open
Objective. We developed a method using cardiovascular magnetic resonance imaging to model the untwisting of the left ventricle (LV) as a damped torsional harmonic oscillator to estimate shear modulus (intrinsic myocardial stiffness) and fr…
View article: Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change
Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change Open
Background Aortic stiffness is an independent predictor of cardiovascular events in patients with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and associated with adverse outcomes. Spironolactone, a m…
View article: Emerging role of cardiovascular magnetic resonance imaging in the management of pulmonary hypertension
Emerging role of cardiovascular magnetic resonance imaging in the management of pulmonary hypertension Open
Pulmonary hypertension (PH) is a clinical condition characterised by elevation of pulmonary arterial pressure (PAP) above normal range due to various aetiologies. While cardiac right-heart catheterisation (RHC) remains the gold standard an…
View article: Leucocyte count predicts cardiovascular risk in heart failure with preserved ejection fraction: insights from TOPCAT Americas
Leucocyte count predicts cardiovascular risk in heart failure with preserved ejection fraction: insights from TOPCAT Americas Open
Aims Prior evidence has implicated leucocyte expansion in several cardiovascular disorders, including heart failure (HF) with reduced ejection fraction (rEF). However, the prognostic importance of leucocyte count in HF with preserved EF (H…
View article: Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation
Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation Open
Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA e…
View article: Role of left ventricle deformation analysis in stress echocardiography for significant coronary artery disease detection: A diagnostic study meta‐analysis
Role of left ventricle deformation analysis in stress echocardiography for significant coronary artery disease detection: A diagnostic study meta‐analysis Open
Background We compared the diagnostic accuracy of longitudinal strain ( LS ) imaging during stress echocardiography with visual assessment of wall motion ( WM ) for detecting significant coronary artery disease ( CAD ). Methods Our systema…
View article: Novel Noninvasive Assessment of Pulmonary Arterial Stiffness Using Velocity Transfer Function
Novel Noninvasive Assessment of Pulmonary Arterial Stiffness Using Velocity Transfer Function Open
Background Pulmonary artery ( PA ) stiffness is associated with increased pulmonary vascular resistance ( PVR ). PA stiffness is accurately described by invasive PA impedance because it considers pulsatile blood flow through elastic PA s. …
View article: Refractory Hypertension Is not Attributable to Intravascular Fluid Retention as Determined by Intracardiac Volumes
Refractory Hypertension Is not Attributable to Intravascular Fluid Retention as Determined by Intracardiac Volumes Open
Refractory hypertension (RfHTN) is an extreme phenotype of antihypertensive treatment failure defined as lack of blood pressure control with ≥5 medications, including a long-acting thiazide and a mineralocorticoid receptor antagonist. RfHT…
View article: Case of Refractory Hypertension Controlled After Aortic and Mitral Valve Replacement and Coronary Artery Bypass Grafting
Case of Refractory Hypertension Controlled After Aortic and Mitral Valve Replacement and Coronary Artery Bypass Grafting Open
This is a case of a patient with refractory hypertension, uncontrolled BP on six antihypertensive medications with mitral regurgitation, aortic insufficiency and coronary artery disease. The patient underwent mitral valve and aortic valve …
View article: Left Ventricular Torsion Shear Angle Volume Approach for Noninvasive Evaluation of Diastolic Dysfunction in Preserved Ejection Fraction
Left Ventricular Torsion Shear Angle Volume Approach for Noninvasive Evaluation of Diastolic Dysfunction in Preserved Ejection Fraction Open
Background Accurate noninvasive diagnostic tools for evaluating left ventricular ( LV ) diastolic dysfunction ( LVDD ) are limited in preserved LV ejection fraction. We previously proposed the relationship of normalized rate of change in L…
View article: Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell–Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine
Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell–Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine Open
Background: Here, we generated human cardiac muscle patches (hCMPs) of clinically relevant dimensions (4 cm × 2 cm × 1.25 mm) by suspending cardiomyocytes, smooth muscle cells, and endothelial cells that had been differentiated from human …