Lo Persson
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View article: The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin
The Molecular Basis for Inhibition of Stemlike Cancer Cells by Salinomycin Open
Tumors are phenotypically heterogeneous and include subpopulations of cancer cells with stemlike properties. The natural product salinomycin, a K+-selective ionophore, was recently found to exert selectivity against such cancer stem cells.…
View article: Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing
Binding and Inhibition of Spermidine Synthase from Plasmodium falciparum and Implications for In Vitro Inhibitor Testing Open
The aminopropyltransferase spermidine synthase (SpdS) is a promising drug target in cancer and in protozoan diseases including malaria. Plasmodium falciparum SpdS (PfSpdS) transfers the aminopropyl group of decarboxylated S-adenosylmethion…
View article: Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs
Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs Open
Synthetic structural analogs of salinomycin, previously shown to exhibit increased activity against cancer cells, also exhibited improved activity against CSCs across several assays even at nanomolar concentrations where salinomycin was fo…