Lo-Yun Chen
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View article: Dual therapeutic potential of Scoparia dulcis in combating hyperglycemia and inflammation in diabetes through network pharmacology and in silico analysis
Dual therapeutic potential of Scoparia dulcis in combating hyperglycemia and inflammation in diabetes through network pharmacology and in silico analysis Open
View article: Zoanthamine-Type Alkaloids Derived from Cultured <i>Zoanthus kuroshio</i> with Therapeutic Potential Against Osteoporosis
Zoanthamine-Type Alkaloids Derived from Cultured <i>Zoanthus kuroshio</i> with Therapeutic Potential Against Osteoporosis Open
Extracts of the zoanthid from Zoanthus kuroshio (ZK) exhibited significant in vitro antiosteoporotic activity in MG-63 cells, prompting the use of Global Natural Products Social Molecular Networking (GNPS) to identify alkaloi…
View article: Computational analysis of zoanthamine alkaloids from Zoanthus sp. as potential DKK1 and GSK-3β inhibitors for osteoporosis therapy via Wnt signaling
Computational analysis of zoanthamine alkaloids from Zoanthus sp. as potential DKK1 and GSK-3β inhibitors for osteoporosis therapy via Wnt signaling Open
View article: Secondary metabolites of Alternaria alternate appraisal of their SARS-CoV-2 inhibitory and anti-inflammatory potentials
Secondary metabolites of Alternaria alternate appraisal of their SARS-CoV-2 inhibitory and anti-inflammatory potentials Open
This study identifies the secondary metabolites from Alternaria alternate and evaluates their ACE-2: Spike RBD (SARS-CoV-2) inhibitory activity confirmed via immunoblotting in human lung microvascular endothelial cells. In addition, their …
View article: Bioassay-guided isolation of terpenoids from the soft coral <i>Sclerophytum humesi</i> and assessment of their antidiabetic and cytotoxic activities
Bioassay-guided isolation of terpenoids from the soft coral <i>Sclerophytum humesi</i> and assessment of their antidiabetic and cytotoxic activities Open
This study represents the first report on the secondary metabolites from the soft coral Sclerophytum humesi .
View article: Unusual Diterpenoids Featuring a 4/9-Fused Ring System from Sclerophytum humesi Trigger Intrinsic Apoptosis via Caspase-Dependent PARP Cleavage in Pancreatic Cancer
Unusual Diterpenoids Featuring a 4/9-Fused Ring System from Sclerophytum humesi Trigger Intrinsic Apoptosis via Caspase-Dependent PARP Cleavage in Pancreatic Cancer Open
View article: Briarane-Type Diterpenes from a Closed-System Cultured Soft Coral Briareum stechei
Briarane-Type Diterpenes from a Closed-System Cultured Soft Coral Briareum stechei Open
View article: Discovery of Novel Zoanthamine-Type Alkaloids Derived from Cultured Zoanthus Kuroshio with Prominent Therapeutic Potential Against Osteoporosis
Discovery of Novel Zoanthamine-Type Alkaloids Derived from Cultured Zoanthus Kuroshio with Prominent Therapeutic Potential Against Osteoporosis Open
View article: Safety evaluation of <i>Plukenetia volubilis</i> seeds: a metabolomic profiling and network toxicology approach
Safety evaluation of <i>Plukenetia volubilis</i> seeds: a metabolomic profiling and network toxicology approach Open
The study indicated the absence of saponins, the presence of phytosterols and trigonellin (a pyridine alkaloid), and a low safety risk related to saponin and alkaloid content in the Sacha Inchi seeds.
View article: Unprecedented anti-inflammatory biscembranoids with 3-hydroperoxy-3-methylcyclohex-1-ene moiety isolated from aquaculture Sarcophyton trocheliophorum
Unprecedented anti-inflammatory biscembranoids with 3-hydroperoxy-3-methylcyclohex-1-ene moiety isolated from aquaculture Sarcophyton trocheliophorum Open
Recent advancements in the discovery of natural products have made significant progress in rapidly identifying known compounds from complex extracts using advanced spectroscopic technologies. Among these methods, one powerful approach call…
View article: Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge Lendenfeldia sp.
Nor-24-homoscalaranes, Neutrophilic Inflammatory Mediators from the Marine Sponge Lendenfeldia sp. Open
The marine sponge Lendenfeldia sp., collected from the Southern waters of Taiwan, was subjected to chemical composition screening, resulting in the isolation of four new 24-homoscalarane compounds, namely lendenfeldaranes R–U (1–4). The st…
View article: Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response
Unlocking the Potential of Octocoral-Derived Secondary Metabolites against Neutrophilic Inflammatory Response Open
Inflammation is a critical defense mechanism that is utilized by the body to protect itself against pathogens and other noxious invaders. However, if the inflammatory response becomes exaggerated or uncontrollable, its original protective …
View article: Quercus coccinea Münchh leaves polyphenols: Appraisal acute lung injury induced by lipopolysaccharide in mice
Quercus coccinea Münchh leaves polyphenols: Appraisal acute lung injury induced by lipopolysaccharide in mice Open
Genus Quercus is a well-known source for its polyphenolic content and important biological activity. Plants belonging to the Quercus genus were traditionally used in asthma, inflammatory diseases, wound healing, acute diarrhea, and hemorrh…
View article: Chemometric-guided chemical marker selection: A case study of the heat-clearing herb Scrophularia ningpoensis
Chemometric-guided chemical marker selection: A case study of the heat-clearing herb Scrophularia ningpoensis Open
The selection of medicinal plants’ chemical markers focuses on bioactivity as the primary goal, followed by the nature of secondary metabolites, their stability, and availability. However, herbal medicines are valued for their complex and …
View article: UHPLC-MS profiles and antidiarrheal activity of Quercus coccinea münchh. and Quercus robur L. employing in vivo technique
UHPLC-MS profiles and antidiarrheal activity of Quercus coccinea münchh. and Quercus robur L. employing in vivo technique Open
Introduction: Quercus L. genus (Oak) belongs to the family Fagaceae and their galls are used commercially in leather tanning, dyeing, and ink preparation. Several Quercus species were traditionally used to manage wound healing, acute diarr…
View article: UHPLC-MS profiles and antidiarrheal activity for two Quercus species grown in Egypt
UHPLC-MS profiles and antidiarrheal activity for two Quercus species grown in Egypt Open
Quercus L. genus (Oak) belongs to the family Fagaceae and their galls are used commercially in leather tanning, dyeing, and ink preparation. Several Quercus species were used traditionally in the management of wound heali…
View article: UHPLC-MS profiles and antidiarrheal activity of Quercus coccinea Münchh. and Quercus robur L. employing in vivo technique
UHPLC-MS profiles and antidiarrheal activity of Quercus coccinea Münchh. and Quercus robur L. employing in vivo technique Open
ABSTRACT Introduction: Quercus L. genus (Oak) belongs to the family Fagaceae and their galls are used commercially in leather tanning, dyeing, and ink preparation. Several Quercus species…
View article: MS/MS Molecular Networking Unveils the Chemical Diversity of Biscembranoid Derivatives, Neutrophilic Inflammatory Mediators from the Cultured Soft Coral Sarcophyton trocheliophorum
MS/MS Molecular Networking Unveils the Chemical Diversity of Biscembranoid Derivatives, Neutrophilic Inflammatory Mediators from the Cultured Soft Coral Sarcophyton trocheliophorum Open
Biscembranoids are the distinctive tetraterpenoids owing a 14/6/14 membered tricyclic scaffold that have been mainly discovered in the soft corals, especially the genera Sarcophyton, Lobophytum and Sinularia. Recent findings have demonstra…
View article: Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential
Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential Open
In recent decades, aquaculture techniques for soft corals have made remarkable progress in terms of conditions and productivity. Researchers have been able to obtain larger quantities of soft corals, thus larger quantities of biologically …
View article: Lonicerae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress
Lonicerae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress Open
Lonicerae japonicae flos (LJ) is an Asian traditional herb that is used as a dietary supplement, tea, and beverage to clear heat and quench thirst. However, no studies investigated its effect on activated human neutrophils, which played a …
View article: Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte
Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte Open
Ultraviolet B (UVB) is one of the most important environmental factors that cause extrinsic aging through increasing intracellular reactive oxygen species (ROS) production in the skin. Due to its protective roles against oxidative stress, …
View article: Chemometric-Guided Exploration of Marine Anti-Neurofibroma Leads
Chemometric-Guided Exploration of Marine Anti-Neurofibroma Leads Open
In-depth analysis of metabolomics diversity of marine species through advanced mass spectrometric analysis is one of the most promising new tools for the development of marine drugs against mild and life-threatening diseases. Neurofibromas…
View article: Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209
Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209 Open
The unmet need for specific anti-leukemic agents for the treatment of acute lymphoblastic leukemia led us to screen a variety of marine-derived bacteria. The fermentation broth extract of Streptomyces sp. LY1209 exhibited the most potent a…
View article: Identification and Characterization of Chlorine-Containing Briaranes from a Cultured Octocoral Briareum excavatum (Briareidae)
Identification and Characterization of Chlorine-Containing Briaranes from a Cultured Octocoral Briareum excavatum (Briareidae) Open
View article: New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp.
New 1,4-Dienonesteroids from the Octocoral Dendronephthya sp. Open
Two new steroids, dendronesterones D (1) and E (2), featuring with 1,4-dienone moiety, along with three known steroids, methyl 3-oxochola-4,22-diene-24-oate (3), 5α,8α-epidioxy-24(S)- methylcholesta-6,22-dien-3β-ol (4), and 5α,8α-epidioxy-…