Loïc Lionnard
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View article: Quantitative imaging and semiotic phenotyping of mitochondrial network morphology in live human cells
Quantitative imaging and semiotic phenotyping of mitochondrial network morphology in live human cells Open
The importance of mitochondria in tissue homeostasis, stress responses and human diseases, combined to their ability to transition between various structural and functional states, makes them excellent organelles for monitoring cell health…
View article: Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder
Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder Open
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with unique changes in mitochondrial metabolism, including elevated respiration rates and morphological alterations. We examined electron transport chain (E…
View article: <i>KCTD</i>: A new gene family involved in neurodevelopmental and neuropsychiatric disorders
<i>KCTD</i>: A new gene family involved in neurodevelopmental and neuropsychiatric disorders Open
The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not appr…