Loka R. Penke
YOU?
Author Swipe
View article: MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution
MAPK phosphatase 1 inhibition of p38α within lung myofibroblasts is essential for spontaneous fibrosis resolution Open
Fibrosis following tissue injury is distinguished from normal repair by the accumulation of pathogenic and apoptosis-resistant myofibroblasts (MFs), which arise primarily by differentiation from resident fibroblasts. Endogenous molecular b…
View article: KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis
KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis Open
There is a paucity of information about potential molecular brakes on the activation of fibroblasts that drive tissue fibrosis. The transcription factor Krüppel-like factor 4 (KLF4) is best known as a determinant of cell stemness and a tum…
View article: ATP citrate lyase links increases in glycolysis to diminished release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages
ATP citrate lyase links increases in glycolysis to diminished release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages Open
View article: Illuminating the lung regenerative potential of prostanoids
Illuminating the lung regenerative potential of prostanoids Open
PGE 2 and PGI 2 receptors are potential targets for the treatment of chronic lung disease.
View article: Kruppel-like factor 4 as a therapeutically tractable brake on lung fibroblast activation which promotes resolution of pulmonary fibrosis
Kruppel-like factor 4 as a therapeutically tractable brake on lung fibroblast activation which promotes resolution of pulmonary fibrosis Open
There is a paucity of information about potential molecular brakes on the activation of fibroblasts that drive tissue fibrosis. The transcription factor Kruppel-like factor 4 (KLF4) is best known as a determinant of cell stemness and a tum…
View article: Pumping the Brakes on Pulmonary Fibrosis: A New Role for Regulator of Cell Cycle
Pumping the Brakes on Pulmonary Fibrosis: A New Role for Regulator of Cell Cycle Open
View article: Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis
Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis Open
View article: Myofibroblast de-Differentiation Proceeds via Distinct Transcriptomic and Phenotypic Transitions
Myofibroblast de-Differentiation Proceeds via Distinct Transcriptomic and Phenotypic Transitions Open
View article: Colony Stimulating Factor-Induced Metabolic Changes Contribute to AM Proliferation via Akt/mTOR Pathway
Colony Stimulating Factor-Induced Metabolic Changes Contribute to AM Proliferation via Akt/mTOR Pathway Open
Rationale: Alveolar macrophages (AMs), the resident phagocytic cells within the lung, are essential for maintenance of lung homeostasis.While at baseline AMs are metabolically quiescent and exhibit low levels of proliferation, alterations …
View article: Bortezomib inhibits lung fibrosis and fibroblast activation without proteasome inhibition
Bortezomib inhibits lung fibrosis and fibroblast activation without proteasome inhibition Open
The FDA-approved proteasomal inhibitor bortezomib (BTZ) has attracted interest for its potential anti-fibrotic actions. However, neither its in vivo efficacy in lung fibrosis nor its dependence on proteasome inhibition has been conclusivel…
View article: Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions
Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions Open
Myofibroblasts are the major cellular source of collagen, and their accumulation - via differentiation from fibroblasts and resistance to apoptosis - is a hallmark of tissue fibrosis. Clearance of myofibroblasts by dedifferentiation and re…
View article: PGE<sub>2</sub>accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
PGE<sub>2</sub>accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking Open
Alveolar macrophages (AMs) are resident immune cells of the lung that are critical for host defense. AMs are capable of proliferative renewal, yet their numbers are known to decrease with aging and increase with cigarette smoking. The mech…
View article: Alveolar macrophage‐derived extracellular vesicles inhibit endosomal fusion of influenza virus
Alveolar macrophage‐derived extracellular vesicles inhibit endosomal fusion of influenza virus Open
View article: Novel Proteasome-Independent Anti-Fibrotic Mechanisms of Bortezomib
Novel Proteasome-Independent Anti-Fibrotic Mechanisms of Bortezomib Open
View article: Mechanisms of Alveolar Macrophage Derived Extracellular Vesicle Defense Against Influenza Infection of Alveolar Epithelial Cells
Mechanisms of Alveolar Macrophage Derived Extracellular Vesicle Defense Against Influenza Infection of Alveolar Epithelial Cells Open
View article: FGF2 and PGE<sub>2</sub> Utilize Distinct Signaling Pathways to Accelerate the Degradation of αSma mRNA in Human Lung Myofibroblasts
FGF2 and PGE<sub>2</sub> Utilize Distinct Signaling Pathways to Accelerate the Degradation of αSma mRNA in Human Lung Myofibroblasts Open
View article: Synthetic Liposomes Containing Suppressor of Cytokine Signaling 3 Protein Dampen Acute Allergic Inflammatory Responses in the Lung
Synthetic Liposomes Containing Suppressor of Cytokine Signaling 3 Protein Dampen Acute Allergic Inflammatory Responses in the Lung Open
View article: Resident alveolar macrophage‐derived vesicular SOCS3 dampens allergic airway inflammation
Resident alveolar macrophage‐derived vesicular SOCS3 dampens allergic airway inflammation Open
Resident alveolar macrophages (AMs) suppress allergic inflammation in murine asthma models. Previously we reported that resident AMs can blunt inflammatory signaling in alveolar epithelial cells (ECs) by transcellular delivery of suppresso…
View article: Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts
Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts Open
Interleukin (IL)−13 is a type 2 cytokine with important roles in allergic diseases, asthma, and tissue fibrosis. Its receptor (R) α1 is primarily responsible for the biological actions of this cytokine, while Rα2 possesses a decoy function…
View article: Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics
Alveolar macrophage secretion of vesicular SOCS3 represents a platform for lung cancer therapeutics Open
Lung cancer remains the leading cause of cancer-related death in the United States. Although the alveolar macrophage (AM) comprises the major resident immune cell in the lung, few studies have investigated its role in lung cancer developme…
View article: Molecular determinants of mesenchymal cell activation in fibroproliferative diseases
Molecular determinants of mesenchymal cell activation in fibroproliferative diseases Open
View article: Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations
Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations Open
GM-CSF is required for alveolar macrophage (AM) development shortly after birth and for maintenance of AM functions throughout life, whereas M-CSF is broadly important for macrophage differentiation and self-renewal. However, the comparati…
View article: 2165 Vesicular secretion of suppressor of cytokine signaling 3 by alveolar macrophages is dysregulated in NSCLC patients and its provision inhibits epithelial cell transformation and tumor cell function
2165 Vesicular secretion of suppressor of cytokine signaling 3 by alveolar macrophages is dysregulated in NSCLC patients and its provision inhibits epithelial cell transformation and tumor cell function Open
OBJECTIVES/SPECIFIC AIMS: Insufficient endogenous expression of suppressor of cytokine signaling 3 (SOCS3) with subsequent over-activation of its target, the transcription factor STAT3, has been associated with tumorigenesis and cancer dev…
View article: FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis
FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis Open
While the transcription factor forkhead box M1 (FOXM1) is well known as a proto-oncogene, its potential role in lung fibroblast activation has never been explored. Here, we show that FOXM1 is more highly expressed in fibrotic than in norma…
View article: Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication
Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication Open
Extracellular vesicles, including exosomes and shed microvesicles (MVs), can be internalized by recipient cells to modulate function. Although the mechanism by which extracellular vesicles are internalized is incompletely characterized, it…
View article: Distinct PKA regulatory subunits mediate PGE<sub>2</sub> inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation
Distinct PKA regulatory subunits mediate PGE<sub>2</sub> inhibition of TGFβ-1-stimulated collagen I translation and myofibroblast differentiation Open
Prostaglandin E 2 (PGE 2 ), via cAMP signaling, inhibits a variety of fibroblast functions relevant to fibrogenesis. Among these are their translation of collagen I protein and their differentiation to myofibroblasts. PKA is central to the…
View article: Megakaryocytes compensate for Kit insufficiency in murine arthritis
Megakaryocytes compensate for Kit insufficiency in murine arthritis Open
The growth factor receptor Kit is involved in hematopoietic and nonhematopoietic development. Mice bearing Kit defects lack mast cells; however, strains bearing different Kit alleles exhibit diverse phenotypes. Herein, we investigated fact…
View article: Alveolar Epithelial Cell–Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation
Alveolar Epithelial Cell–Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation Open
Preservation of gas exchange mandates that the pulmonary alveolar surface restrain unnecessarily harmful inflammatory responses to the many challenges to which it is exposed. These responses reflect the cross-talk between alveolar epitheli…
View article: Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling
Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling Open
JAK-STAT signaling mediates the actions of numerous cytokines and growth factors, and its endogenous brake is the family of SOCS proteins. Consistent with their intracellular roles, SOCS proteins have never been identified in the extracell…