Lon J. Van Winkle
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View article: Adaptation and changing phenotypes through transgenerational epigenetics
Adaptation and changing phenotypes through transgenerational epigenetics Open
In this article collection, we describe how noncoding epigenetic changes in DNA are transmitted across multiple generations in eukaryotic organisms including plants and animals. And such environmentally induced biochemical alterations of D…
View article: Genetics, Epigenetics, and the Environment: Are Precision Medicine, Provider Compassion, and Social Justice Effective Public Health Measures to Mitigate Disease Risk and Severity?
Genetics, Epigenetics, and the Environment: Are Precision Medicine, Provider Compassion, and Social Justice Effective Public Health Measures to Mitigate Disease Risk and Severity? Open
Environmental forces impacting public health include exposure to toxic substances, adverse childhood experiences (ACEs), diet, and exercise. Here, we examine the first two of these forces in some detail since they may be amenable to correc…
View article: Substantial Increases in Healthcare Students’ State Empathy Scores Owing to Participation in a Single Improvisation Session
Substantial Increases in Healthcare Students’ State Empathy Scores Owing to Participation in a Single Improvisation Session Open
Purpose: To determine whether the 12-item state empathy scale could be modified reliably to measure empathy in healthcare professions students and to detect changes in their empathy owing to a single improvisation (improv) session. Methods…
View article: Survey of attitudes toward performing and reflecting on required team service-learning (SASL): psychometric data and reliability/validity for healthcare professions students in preclinical courses
Survey of attitudes toward performing and reflecting on required team service-learning (SASL): psychometric data and reliability/validity for healthcare professions students in preclinical courses Open
Purpose Previously we assessed healthcare professional students’ feelings about team-based learning, implicit bias, and service to the community using an in-house paper survey. In this study, we determined whether this survey is a reliable…
View article: Editorial: Mitigating implicit bias and promoting compassionate behavior in public health/healthcare professionals: implications for treatment outcomes
Editorial: Mitigating implicit bias and promoting compassionate behavior in public health/healthcare professionals: implications for treatment outcomes Open
Partly because it is unconscious, managing implicit bias in public health/healthcare remains intractable. Hence, administrators, practitioners, and their students unknowingly discriminate against others especially including socioeconomical…
View article: Editorial: From single stem cells to organoids, organ repair, and public health Volume II
Editorial: From single stem cells to organoids, organ repair, and public health Volume II Open
EDITORIAL article Front. Cell Dev. Biol., 25 September 2023Sec. Stem Cell Research Volume 11 - 2023 | https://doi.org/10.3389/fcell.2023.1294407
View article: Molecular and Clinical Advances in Understanding Early Embryo Development
Molecular and Clinical Advances in Understanding Early Embryo Development Open
The articles in this Special Issue address a wide variety of topics concerning molecular and clinical advances in understanding early embryo development [...]
View article: Editorial: Emerging talents in pharmacology: Drugs outcomes research and policies 2022
Editorial: Emerging talents in pharmacology: Drugs outcomes research and policies 2022 Open
EDITORIAL article Front. Pharmacol., 02 March 2023Sec. Drugs Outcomes Research and Policies Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1162703
View article: Perspective: Might Maternal Dietary Monosodium Glutamate (MSG) Consumption Impact Pre- and Peri-Implantation Embryos and Their Subsequent Development?
Perspective: Might Maternal Dietary Monosodium Glutamate (MSG) Consumption Impact Pre- and Peri-Implantation Embryos and Their Subsequent Development? Open
MSG alters metabolism, especially in the brain, when administered to experimental animals via gavage or similar means. Such administration is, however, not applicable to humans. More recently, though, MSG was shown to have these effects ev…
View article: Critical reflection on required service to the community propels prospective medical students toward higher empathy, compassion, and bias mitigation but are these gains sustainable?
Critical reflection on required service to the community propels prospective medical students toward higher empathy, compassion, and bias mitigation but are these gains sustainable? Open
Purpose We observed increased cognitive empathy and reflective capacity scores when prospective medical students wrote critical reflections on mandatory team service-learning in a Medical Humanities course, but these findings did not inclu…
View article: Epigenetic Regulation of Development, Cellular Differentiation, and Disease Progression/Protection in Adults
Epigenetic Regulation of Development, Cellular Differentiation, and Disease Progression/Protection in Adults Open
Epigenetic changes drive early embryonic and later stages of development [...]
View article: Editorial: From Single Stem Cells to Organoids, Organ Repair, and Public Health
Editorial: From Single Stem Cells to Organoids, Organ Repair, and Public Health Open
EDITORIAL article Front. Cell Dev. Biol., 11 February 2022 | https://doi.org/10.3389/fcell.2022.849889
View article: Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications
Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications Open
Embryo/fetal nutrition and the environment in the reproductive tract influence the subsequent risk of developing adult diseases and disorders, as formulated in the Barker hypothesis. Metabolic syndrome, obesity, heart disease, and hyperten…
View article: Amino Acid Transport and Metabolism Regulate Early Embryo Development: Species Differences, Clinical Significance, and Evolutionary Implications
Amino Acid Transport and Metabolism Regulate Early Embryo Development: Species Differences, Clinical Significance, and Evolutionary Implications Open
In this review we discuss the beneficial effects of amino acid transport and metabolism on pre- and peri-implantation embryo development, and we consider how disturbances in these processes lead to undesirable health outcomes in adults. Pr…
View article: Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals
Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals Open
In multicellular organisms, tissue generation, maintenance, and homeostasis depend on stem cells. Cellular metabolic status is an essential component of different differentiated states, from stem to fully differentiated cells. Threonine (T…
View article: Impact of a Pandemic and Remote Learning on Team Development and Elements of Compassion in Prospective Medical Students Taking a Medical Humanities Course
Impact of a Pandemic and Remote Learning on Team Development and Elements of Compassion in Prospective Medical Students Taking a Medical Humanities Course Open
Introduction: We reported previously that when teams of students reflect on readings about communication, unconscious bias, and service-learning, their critical reflection, implicit bias mitigation, empathy, and compassionate behavior all …
View article: Commentary: Fostering Bias Mitigation and Compassionate Behavior in Dental and Other Healthcare Professional Students and Practitioners
Commentary: Fostering Bias Mitigation and Compassionate Behavior in Dental and Other Healthcare Professional Students and Practitioners Open
Unconscious bias remains a poorly managed global problem. For example, implicit bias alters perceptions concerning tooth restorability. Dentists and other healthcare professionals harbor attitudes against various categories of people and t…
View article: Perspective: One-Cell and Cleavage-Stage Mouse Embryos Thrive in Hyperosmotic Oviductal Fluid Through Expression of a Glycine Neurotransmitter Transporter and a Glycine-Gated Chloride Channel: Clinical and Transgenerational Implications
Perspective: One-Cell and Cleavage-Stage Mouse Embryos Thrive in Hyperosmotic Oviductal Fluid Through Expression of a Glycine Neurotransmitter Transporter and a Glycine-Gated Chloride Channel: Clinical and Transgenerational Implications Open
The osmolality of mouse oviductal fluid ranges from about 300 mOsmol/kg in the ampulla 0–3 h post coitus (h p.c.) to more than 350 mOsmol/kg in the isthmus 34–36 h p.c. Thus, it has been surprising to find that development of one-cell and …
View article: Lysine Deprivation during Maternal Consumption of Low-Protein Diets Could Adversely Affect Early Embryo Development and Health in Adulthood
Lysine Deprivation during Maternal Consumption of Low-Protein Diets Could Adversely Affect Early Embryo Development and Health in Adulthood Open
The conversion of lysine to glutamate is needed for signaling in all plants and animals. In mouse embryonic stem (mES) cells, and probably their progenitors, endogenous glutamate production and signaling help maintain cellular pluripotency…
View article: Consumption of a Branched-Chain Amino Acid (BCAA) during Days 2–10 of Pregnancy Causes Abnormal Fetal and Placental Growth: Implications for BCAA Supplementation in Humans
Consumption of a Branched-Chain Amino Acid (BCAA) during Days 2–10 of Pregnancy Causes Abnormal Fetal and Placental Growth: Implications for BCAA Supplementation in Humans Open
A relatively large branched-chain amino acid (BCAA) supplement, consumed for more than 10 days, appears to be especially effective at alleviating muscle damage and soreness during intense human training. However, perturbations in amino aci…
View article: Fostering Empathy, Implicit Bias Mitigation, and Compassionate Behavior in a Medical Humanities Course
Fostering Empathy, Implicit Bias Mitigation, and Compassionate Behavior in a Medical Humanities Course Open
Increases in compassionate behavior improve patient outcomes and reduce burnout among healthcare professionals. We predicted that selecting and performing service-learning projects by teams of prospective medical students in a Medical Huma…
View article: One-Carbon Metabolism Regulates Embryonic Stem Cell Fate Through Epigenetic DNA and Histone Modifications: Implications for Transgenerational Metabolic Disorders in Adults
One-Carbon Metabolism Regulates Embryonic Stem Cell Fate Through Epigenetic DNA and Histone Modifications: Implications for Transgenerational Metabolic Disorders in Adults Open
Human (h) and mouse (m) embryonic stem (ES) cells need specific amino acids to proliferate. mES cells require threonine (Thr) metabolism for epigenetic histone modifications. Thr is converted to glycine and acetyl CoA, and the glycine is m…
View article: Selecting and Performing Service-Learning in a Team-Based Learning Format Fosters Dissonance, Reflective Capacity, Self-Examination, Bias Mitigation, and Compassionate Behavior in Prospective Medical Students
Selecting and Performing Service-Learning in a Team-Based Learning Format Fosters Dissonance, Reflective Capacity, Self-Examination, Bias Mitigation, and Compassionate Behavior in Prospective Medical Students Open
More compassionate behavior should make both patients and their providers happier and healthier. Consequently, work to increase this behavior ought to be a major component of premedical and medical education. Interactions between doctors a…
View article: Applications of the reflective practice questionnaire in medical education
Applications of the reflective practice questionnaire in medical education Open
The RPQ is a reliable measure of reflective capacity (Chronbach's alpha value = 0.84) and related characteristics (Cronbach's alpha values from 0.75 to 0.83) in medical students. The RPQ can be used as part of pre-post evaluations of medic…
View article: Can uterine secretion of modified histones alter blastocyst implantation, embryo nutrition, and transgenerational phenotype?
Can uterine secretion of modified histones alter blastocyst implantation, embryo nutrition, and transgenerational phenotype? Open
Extracellular histones support rodent and human embryo development in at least two ways. First, these molecules in uterine secretions protect embryos from inflammation caused by pathogens that gain access to the reproductive tract. Also, h…
View article: A Model to Promote Public Health by Adding Evidence-Based, Empathy-Enhancing Programs to All Undergraduate Health-care Curricula
A Model to Promote Public Health by Adding Evidence-Based, Empathy-Enhancing Programs to All Undergraduate Health-care Curricula Open
Fostering empathy in future health-care providers through service-learning is emerging as central to public health promotion. Patients fare better when their caregivers have higher relationship-centered characteristics such as the ones mea…
View article: Uterine Histone Secretion Likely Fosters Early Embryo Development So Efforts to Mitigate Histone Cytotoxicity Should Be Cautious
Uterine Histone Secretion Likely Fosters Early Embryo Development So Efforts to Mitigate Histone Cytotoxicity Should Be Cautious Open
OPINION article Front. Cell Dev. Biol., 27 November 2017Sec. Signaling Volume 5 - 2017 | https://doi.org/10.3389/fcell.2017.00100
View article: When Is Team Exam Performance a Better Measure of Learning than Individual Performance?
When Is Team Exam Performance a Better Measure of Learning than Individual Performance? Open
OPINION article Front. Educ., 17 May 2017Sec. Assessment, Testing and Applied Measurement Volume 2 - 2017 | https://doi.org/10.3389/feduc.2017.00020
View article: Editorial: Inter-healthcare Professions Collaboration: Educational and Practical Aspects and New Developments
Editorial: Inter-healthcare Professions Collaboration: Educational and Practical Aspects and New Developments Open
EDITORIAL article Front. Pharmacol., 12 September 2016Sec. Drugs Outcomes Research and Policies Volume 7 - 2016 | https://doi.org/10.3389/fphar.2016.00306
View article: At Least Three Transporters Likely Mediate Threonine Uptake Needed for Mouse Embryonic Stem Cell Proliferation
At Least Three Transporters Likely Mediate Threonine Uptake Needed for Mouse Embryonic Stem Cell Proliferation Open
Stem cells are at the forefront of current regenerative and biomedical research. Thus, there exists an imperative and urgent need to understand the mechanisms that drive stem cell function in order to exploit their use as a therapeutic too…