Lei Wang
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View article: <scp>DL</scp> ‐3‐n‐Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing <scp>GCN5L1</scp> ‐Mediated Drp1 Acetylation in Neurons and Mouse Brains
<span>DL</span> ‐3‐n‐Butylphthalide Protects Mitochondria Against Ischemia/Hypoxia Damage via Suppressing <span>GCN5L1</span> ‐Mediated Drp1 Acetylation in Neurons and Mouse Brains Open
Background Mitochondrial dysfunction is an initial event of the cascade reactions triggered by ischemic stroke, contributing to the pathogenesis of ischemic brain injury. DL ‐3‐n‐butylphthalide ( NBP ), a compound originally isolated from …
View article: Development and validation of nomograms for predicting grade ≥3 diarrhea and neutropenia after abemaciclib combined with endocrine therapy for breast cancer: a multicenter retrospective real-world study
Development and validation of nomograms for predicting grade ≥3 diarrhea and neutropenia after abemaciclib combined with endocrine therapy for breast cancer: a multicenter retrospective real-world study Open
Background This study aimed to investigate the risk factors associated with grade ≥3 diarrhea and neutropenia, which are the most common adverse events (AEs) leading to discontinuation and dose reduction in patients with hormone receptor-p…
View article: [Effects of <i>MTHFR</i> and <i>GGH</i> gene polymorphisms on plasma concentrations and toxicity following high-dose methotrexate therapy in children with acute lymphoblastic leukemia].
[Effects of <i>MTHFR</i> and <i>GGH</i> gene polymorphisms on plasma concentrations and toxicity following high-dose methotrexate therapy in children with acute lymphoblastic leukemia]. Open
Detection of MTHFR rs1801133 and GGH rs11545078 genotypes can be used to predict increased MTX plasma concentrations and the occurrence of toxic reactions in high-dose MTX treatment of ALL, enabling timely interventions to enhance safety.
View article: Multiplexed self-adaptable Janus hydrogels rescue epithelial malfunction to promote complete trachea repair
Multiplexed self-adaptable Janus hydrogels rescue epithelial malfunction to promote complete trachea repair Open
Epithelial malfunction rescue is the decisive step involved in complete trachea repair; however, this step remains challenging due to the harsh tracheal environment and unclear pathogenesis, which still made current bioengineered trachea t…
View article: Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway Open
Metastasis remains a major obstacle limiting the survival of patients with osteosarcoma (OS). Cross-talk between cancer-associated fibroblasts (CAFs) and OS cells has been found to facilitate metastasis, although the effects of CAFs on OS …
View article: Real-world safety of carboplatin in non-small cell lung cancer: a retrospective signal detection and subgroup analysis based on the FAERS database
Real-world safety of carboplatin in non-small cell lung cancer: a retrospective signal detection and subgroup analysis based on the FAERS database Open
Introduction Carboplatin is frequently employed in the treatment of non-small cell lung cancer (NSCLC), yet the real-world safety profile—including underrecognized adverse events (AEs) and subgroup-specific risk variations—remains incomple…
View article: Lysine Acetyltransferase 8: A Target for Natural Compounds in Cancer Therapy
Lysine Acetyltransferase 8: A Target for Natural Compounds in Cancer Therapy Open
Lysine acetyltransferase 8 (KAT8) is a member of the MYST family of histone acetyltransferases. It catalyzes the acetylation of histone H4 at lysine 16 (H4K16ac) and non-histone proteins. Abnormal upregulation or downregulation of KAT8 and…
View article: Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway
Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway Open
Acanthopanax senticosus is a unique wild resource in Northeast China. Its main active ingredient is a polysaccharide, which has a prominent immunomodulatory effect. In this study, the purified polysaccharide component of Acanthopanax senti…
View article: The Mediating Role of Cortical Atrophy on the Relationship between the Resilience Index and Cognitive Function: Findings from the Healthy Brain Initiative
The Mediating Role of Cortical Atrophy on the Relationship between the Resilience Index and Cognitive Function: Findings from the Healthy Brain Initiative Open
Introduction Background: Lifestyle factors are linked to differences in brain aging and risk for Alzheimer’s disease, underscored by concepts like ‘cognitive reserve’ and ‘brain maintenance’. The Resilience Index (RI), a composite of 6 fac…
View article: Astroglial TNFR2 signaling regulates hippocampal synaptic function and plasticity in a sex dependent manner
Astroglial TNFR2 signaling regulates hippocampal synaptic function and plasticity in a sex dependent manner Open
Astrocytes participate in synaptic transmission and plasticity through tightly regulated, bidirectional communication with pre- and post-synaptic neurons, as well as microglia and oligodendrocytes. A key component of astrocyte-mediated syn…
View article: Exploring the lncRNA NEAT1/iASPP Pathway in Chordoma: Mechanisms of Proliferation Suppression and Apoptosis Induction
Exploring the lncRNA NEAT1/iASPP Pathway in Chordoma: Mechanisms of Proliferation Suppression and Apoptosis Induction Open
In chordoma, lncRNA NEAT1 is highly expressed, and silencing lncRNA NEAT1 inhibits the proliferation and induces apoptosis of chordoma cells while decreasing the expression of iASPP. These findings offer new insights into the involvement o…
View article: SENP<scp>1</scp> reduces oxidative stress and apoptosis in renal ischaemia–reperfusion injury by <scp>de</scp>SUMO<scp>ylation</scp> of HIF‐1α
SENP<span>1</span> reduces oxidative stress and apoptosis in renal ischaemia–reperfusion injury by <span>de</span>SUMO<span>ylation</span> of HIF‐1α Open
Renal ischaemia–reperfusion injury (RIRI) is a primary cause of acute kidney damage, occurring frequently in situations like renal transplantation, yet the underlying mechanisms were not fully understood. Sentrin‐specific protease 1 (SENP1…
View article: Platelet-Rich Fibrin Increases CXCL8 Expression in Gingival Fibroblasts
Platelet-Rich Fibrin Increases CXCL8 Expression in Gingival Fibroblasts Open
Platelet-rich fibrin (PRF), the coagulated plasma of fractionated blood, is widely used to support tissue regeneration in dentistry, and the underlying cellular and molecular mechanisms are increasingly being understood. Periodontal connec…
View article: An insulin-like signalling pathway model for Fasciola gigantica
An insulin-like signalling pathway model for Fasciola gigantica Open
Background The insulin/insulin-like signalling (IIS) pathway is common in mammals and invertebrates, and the IIS pathway is unknown in Fasciola gigantica. In the present study, the IIS pathway was reconstructed in F. gigantica . We defined…
View article: Editorial: Mechanism and treatment for pancreatic cancer metastases
Editorial: Mechanism and treatment for pancreatic cancer metastases Open
Keywords: pancreatic cancer, metastases, chemotherapy, immunotherapy, tumor immune microenvironment (TIME)
View article: The role of gut microbiota associated metabolites in digestive disorders
The role of gut microbiota associated metabolites in digestive disorders Open
The gut has been a focal point in the research of digestive system disorders. The internal microbiota generates metabolites that function as signaling molecules and substrates, interacting with the intestinal wall and influencing host phys…
View article: Effects of Dietary l-Glutamine Supplementation on the Intestinal Function and Muscle Growth of Piglets
Effects of Dietary l-Glutamine Supplementation on the Intestinal Function and Muscle Growth of Piglets Open
The aim of this study was to investigate the effects of dietary l-glutamine (Gln) supplementation on the morphology and function of the intestine and the growth of muscle in piglets. In this study, sixteen 21-day-old piglets were randomly …