Longhao Zhang
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View article: Spatiotemporal landscape of intrahepatic cholangiocarcinoma liver metastasis at the single-cell level
Spatiotemporal landscape of intrahepatic cholangiocarcinoma liver metastasis at the single-cell level Open
Background and Aims: Intrahepatic cholangiocarcinoma (iCCA) is a highly metastatic tumor type, and iCCA with intrahepatic metastasis is associated with poor prognosis. Previous studies have confirmed that the tumor microenvironment (TME) i…
View article: Metabolic collusion driving immune evasion in cholangiocarcinoma: unmasking the dual control of the immuno-metabolic microenvironment
Metabolic collusion driving immune evasion in cholangiocarcinoma: unmasking the dual control of the immuno-metabolic microenvironment Open
Cholangiocarcinoma represents an aggressive malignancy with poor prognosis, particularly for intrahepatic Cholangiocarcinoma. Despite recent advancements in chemotherapy and immune checkpoint blockade therapies, survival outcomes remain su…
View article: Exploration of Differences in Housing Price Determinants Based on Street View Imagery and the Geographical-XGBoost Model: Improving Quality of Life for Residents and Through-Travelers
Exploration of Differences in Housing Price Determinants Based on Street View Imagery and the Geographical-XGBoost Model: Improving Quality of Life for Residents and Through-Travelers Open
Street design quality and socio-economic factors jointly influence housing prices, but their intertwined effects and spatial variations remain under-quantified. Housing prices not only reflect residents’ neighborhood experiences but also s…
View article: Immunotherapy in biliary tract cancer: reshaping the tumour microenvironment and advancing precision combination strategies
Immunotherapy in biliary tract cancer: reshaping the tumour microenvironment and advancing precision combination strategies Open
Biliary tract cancer, which includes intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer, presents a significant clinical challenge because of its aggressive nature and limited therapeutic options. Alth…
View article: Unexpected Origin: Gastric Mature Cystic Teratoma Presenting as a Hepatic Mass
Unexpected Origin: Gastric Mature Cystic Teratoma Presenting as a Hepatic Mass Open
View article: Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis
Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditis Open
View article: Correction: Efficacy and safety of lenvatinib combined with anti-PD-1 antibodies plus GEMOX chemotherapy as non-first-line systemic therapy in advanced gallbladder cancer
Correction: Efficacy and safety of lenvatinib combined with anti-PD-1 antibodies plus GEMOX chemotherapy as non-first-line systemic therapy in advanced gallbladder cancer Open
View article: Peripheral blood PD-1+ T lymphocytes as biomarkers in liquid biopsies for solid tumors: Clinical significance and prognostic applications
Peripheral blood PD-1+ T lymphocytes as biomarkers in liquid biopsies for solid tumors: Clinical significance and prognostic applications Open
A shift toward a T cell exhaustion phenotype is associated with the upregulation of expression of programmed cell death protein 1 (PD-1) on T lymphocytes in patients with malignant solid tumors. The interaction between PD-1 and programmed …
View article: Exploring the Complex Association Between Urban Built Environment, Sociodemographic Characteristics and Crime: Evidence from Washington, D.C.
Exploring the Complex Association Between Urban Built Environment, Sociodemographic Characteristics and Crime: Evidence from Washington, D.C. Open
The urban built environment and sociodemographic characteristics have complex relationships with urban crime. However, previous studies have had limitations such as generalizing urban green space types, urban functionality, and sociodemogr…
View article: Efficacy and safety of lenvatinib combined with anti-PD-1 antibodies plus GEMOX chemotherapy as non-first-line systemic therapy in advanced gallbladder cancer
Efficacy and safety of lenvatinib combined with anti-PD-1 antibodies plus GEMOX chemotherapy as non-first-line systemic therapy in advanced gallbladder cancer Open
Anti-PD-1 antibodies combined with lenvatinib and GEMOX chemotherapy are effective and well-tolerated as a non-first-line therapy in advanced GBC. PD-L1 expression and baseline NLR may potentially predict treatment efficacy.
View article: Full-scale polymer relaxation induced by single-chain confinement enhances mechanical stability of nanocomposites
Full-scale polymer relaxation induced by single-chain confinement enhances mechanical stability of nanocomposites Open
Polymer nanocomposites with tuning functions are exciting candidates for various applications, and most current research has focused on static mechanical reinforcement. Actually, under service conditions of complex dynamic interference, st…
View article: Gut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer
Gut microbiota and metabolites signatures of clinical response in anti-PD-1/PD-L1 based immunotherapy of biliary tract cancer Open
Background Accumulating evidence suggests that the gut microbiota and metabolites can modulate tumor responses to immunotherapy; however, limited data has been reported on biliary tract cancer (BTC). This study used metagenomics and metabo…
View article: Characterizations of multi-kingdom gut microbiota in immune checkpoint inhibitor-treated hepatocellular carcinoma
Characterizations of multi-kingdom gut microbiota in immune checkpoint inhibitor-treated hepatocellular carcinoma Open
Background The association between gut bacteria and the response to immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC) has been studied; however, multi-kingdom gut microbiome alterations and interactions in ICI-treated HC…
View article: Conversion surgery intervention versus continued systemic therapy in patients with a response after PD-1/PD-L1 inhibitor-based combination therapy for initially unresectable biliary tract cancer: a retrospective cohort study
Conversion surgery intervention versus continued systemic therapy in patients with a response after PD-1/PD-L1 inhibitor-based combination therapy for initially unresectable biliary tract cancer: a retrospective cohort study Open
Background: The role of conversion surgery in patients with unresectable biliary tract cancer who responded positively to PD-1/PD-L1 inhibitor-based therapy remains unclear. This study aimed to assess the outcomes in patients with or witho…
View article: Scoping review of obesity interventions: Research frontiers and publication status
Scoping review of obesity interventions: Research frontiers and publication status Open
Obesity and overweight are significant global health issues, and numerous obesity intervention studies have been conducted. Summarizing current knowledge of interventions aims to inform researchers and policymakers to keep up-to-date with …
View article: Biomarkers and prognostic factors of PD-1/PD-L1 inhibitor-based therapy in patients with advanced hepatocellular carcinoma
Biomarkers and prognostic factors of PD-1/PD-L1 inhibitor-based therapy in patients with advanced hepatocellular carcinoma Open
Systemic therapies using programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) inhibitors have demonstrated commendable efficacy in some patients with advanced hepatocellular carcinoma (HCC); however, other individuals do not res…
View article: MaTe3D: Mask-guided Text-based 3D-aware Portrait Editing
MaTe3D: Mask-guided Text-based 3D-aware Portrait Editing Open
3D-aware portrait editing has a wide range of applications in multiple fields. However, current approaches are limited due that they can only perform mask-guided or text-based editing. Even by fusing the two procedures into a model, the ed…
View article: VividTalk: One-Shot Audio-Driven Talking Head Generation Based on 3D Hybrid Prior
VividTalk: One-Shot Audio-Driven Talking Head Generation Based on 3D Hybrid Prior Open
Audio-driven talking head generation has drawn much attention in recent years, and many efforts have been made in lip-sync, expressive facial expressions, natural head pose generation, and high video quality. However, no model has yet led …
View article: Efficacy and safety of subsequent radiotherapy in patients with advanced-stage hepatocellular carcinoma treated with immune checkpoint inhibitors
Efficacy and safety of subsequent radiotherapy in patients with advanced-stage hepatocellular carcinoma treated with immune checkpoint inhibitors Open
Subsequent RT showed reliable antitumor effects and an acceptable safety profile in patients with advanced-stage HCC who had unsatisfactory response to ICI therapy; therefore, it could serve as an optional salvage strategy.
View article: Real-world cohort study of PD-1 blockade plus lenvatinib for advanced intrahepatic cholangiocarcinoma: effectiveness, safety, and biomarker analysis
Real-world cohort study of PD-1 blockade plus lenvatinib for advanced intrahepatic cholangiocarcinoma: effectiveness, safety, and biomarker analysis Open
View article: Efficacy, safety, and prognostic factors of PD-1 inhibitors combined with lenvatinib and Gemox chemotherapy as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter real-world study
Efficacy, safety, and prognostic factors of PD-1 inhibitors combined with lenvatinib and Gemox chemotherapy as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter real-world study Open
Background A programmed cell death protein-1 (PD-1) inhibitor combined with lenvatinib and Gemox chemotherapy as first-line therapy demonstrated high anti-tumor activity against biliary tract cancer in phase II clinical trials. Herein, we …
View article: One-Shot High-Fidelity Talking-Head Synthesis with Deformable Neural Radiance Field
One-Shot High-Fidelity Talking-Head Synthesis with Deformable Neural Radiance Field Open
Talking head generation aims to generate faces that maintain the identity information of the source image and imitate the motion of the driving image. Most pioneering methods rely primarily on 2D representations and thus will inevitably su…
View article: Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma
Clinical outcomes of lenvatinib plus transarterial chemoembolization with or without programmed death receptor-1 inhibitors in unresectable hepatocellular carcinoma Open
Our results suggest that the early combination of PD-1 inhibitors has manageable toxicity and hopeful efficacy in patients with uHCC.
View article: Effectiveness and safety of radiotherapy plus programmed death-1 inhibitors and lenvatinib in patients with advanced biliary tract carcinoma: a real-world study
Effectiveness and safety of radiotherapy plus programmed death-1 inhibitors and lenvatinib in patients with advanced biliary tract carcinoma: a real-world study Open
View article: [Frontiers and development in live-cell super-resolution fluorescence microscopy].
[Frontiers and development in live-cell super-resolution fluorescence microscopy]. Open
This paper reviews the research progress on live-cell super-resolution fluorescence microscopy, discusses the current research status and hotspots in this field, and summarizes the technological application of super-resolution fluorescence…
View article: Efficacy and safety of lenvatinib combined with PD-1/PD-L1 inhibitors plus Gemox chemotherapy in advanced biliary tract cancer
Efficacy and safety of lenvatinib combined with PD-1/PD-L1 inhibitors plus Gemox chemotherapy in advanced biliary tract cancer Open
Background Lenvatinib combined with anti-PD-1 antibodies and systemic chemotherapy has demonstrated a relatively high antitumor activity for intrahepatic cholangiocarcinoma in phase 2 clinical trials. However, its efficacy and safety in ad…
View article: Safety and feasibility of toripalimab plus lenvatinib with or without radiotherapy in advanced BTC
Safety and feasibility of toripalimab plus lenvatinib with or without radiotherapy in advanced BTC Open
Background Toripalimab shows antitumor efficacy in cholangiocarcinoma. Radiotherapy (RT) may enhance systemic responses of PD-1 inhibitors and lenvatinib. This study was designed to assess the safety and feasibility of toripalimab plus len…
View article: The efficacy and safety of bevacizumab as a salvage therapy for patients with advanced hepatocellular carcinoma targeting immune tolerance.
The efficacy and safety of bevacizumab as a salvage therapy for patients with advanced hepatocellular carcinoma targeting immune tolerance. Open
As is well understood that malignant tumour progression requires additional blood vessels to provide the nutrients necessary for growth. Many patients with advanced hepatocellular carcinoma (aHCC) experience disease progression after treat…
View article: High incidence combination of multiple primary malignant tumors of the digestive system
High incidence combination of multiple primary malignant tumors of the digestive system Open
Screening for lung cancer should be performed six months after the detection of colon cancer while rectal cancer screening should be performed within six months.
View article: Analysis and Prediction of Subway Tunnel Surface Subsidence Based on Internet of Things Monitoring and BP Neural Network
Analysis and Prediction of Subway Tunnel Surface Subsidence Based on Internet of Things Monitoring and BP Neural Network Open
With the acceleration of the urban development process and the rapid growth of China’s population, the subway has become the first choice for people to travel, and the urban underground space has been continuously improved. The subway cons…