Longhua Liu
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View article: Multifaced roles of adipokines in endothelial cell function
Multifaced roles of adipokines in endothelial cell function Open
Obesity significantly contributes to the progression of cardiovascular diseases (CVDs) and elevates the risk of cardiovascular mortality. Atherosclerosis, the primary pathogenic process underlying CVDs, initiates with vascular endothelial …
View article: GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses
GEPREP: A comprehensive data atlas of RNA-seq-based gene expression profiles of exercise responses Open
View article: Diverse associations between pancreatic intra-, inter-lobular fat and the development of type 2 diabetes in overweight or obese patients
Diverse associations between pancreatic intra-, inter-lobular fat and the development of type 2 diabetes in overweight or obese patients Open
Pancreatic fat is associated with obesity and type 2 diabetes mellitus (T2DM); however, the relationship between different types of pancreatic fat and diabetes status remains unclear. Therefore, we aimed to determine the potential of diffe…
View article: PPARγ in Atherosclerotic Endothelial Dysfunction: Regulatory Compounds and PTMs
PPARγ in Atherosclerotic Endothelial Dysfunction: Regulatory Compounds and PTMs Open
The formation of atherosclerotic plaques is one of the main sources of cardiovascular disease. In addition to known risk factors such as dyslipidemia, diabetes, obesity, and hypertension, endothelial dysfunction has been shown to play a ke…
View article: Exercise Promotes Bone Marrow Microenvironment by Inhibiting Adipsin in Diet-Induced Male Obese Mice
Exercise Promotes Bone Marrow Microenvironment by Inhibiting Adipsin in Diet-Induced Male Obese Mice Open
Obesity is a growing global epidemic linked to many diseases, including diabetes, cardiovascular diseases, and musculoskeletal disorders. Exercise can improve bone density and decrease excess bone marrow adipose tissue (BMAT) in obese indi…
View article: The Potential Roles of Post-Translational Modifications of PPARγ in Treating Diabetes
The Potential Roles of Post-Translational Modifications of PPARγ in Treating Diabetes Open
The number of patients with type 2 diabetes mellitus (T2DM), which is mainly characterized by insulin resistance and insulin secretion deficiency, has been soaring in recent years. Accompanied by many other metabolic syndromes, such as car…
View article: PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia
PPARγ (Peroxisome Proliferator-Activated Receptor γ) Deacetylation Suppresses Aging-Associated Atherosclerosis and Hypercholesterolemia Open
Background: Atherosclerosis is a medical urgency manifesting at the onset of hypercholesterolemia and is associated with aging. Activation of PPARγ (peroxisome proliferator-activated receptor γ) counteracts metabolic dysfunction influenced…
View article: PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms
PPARγ Acetylation Orchestrates Adipose Plasticity and Metabolic Rhythms Open
Systemic glucose metabolism and insulin activity oscillate in response to diurnal rhythms and nutrient availability with the necessary involvement of adipose tissue to maintain metabolic homeostasis. However, the adipose‐intrinsic regulato…
View article: Adipokines, adiposity, and atherosclerosis
Adipokines, adiposity, and atherosclerosis Open
View article: The Role of Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and Selective Modulators
The Role of Peroxisome Proliferator-Activated Receptor Gamma and Atherosclerosis: Post-translational Modification and Selective Modulators Open
Atherosclerosis is the hallmark of cardiovascular disease (CVD) which is a leading cause of death in type 2 diabetes patients, and glycemic control is not beneficial in reducing the potential risk of CVD. Clinically, it was shown that Thia…
View article: Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells
Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells Open
Background: Marrow adipose tissue (MAT) has been shown to be vital for regulating metabolism and maintaining skeletal homeostasis in the bone marrow (BM) niche. As a reflection of BM remodeling, MAT is highly responsive to nutrient fluctua…
View article: Author response: Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells
Author response: Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells Open
View article: Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells
Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells Open
Background Bone marrow (BM) adipose tissue (BMAT) has been shown to be vital for regulating metabolism and maintaining skeletal homeostasis in the marrow niche. As a reflection of BM remodeling, BMAT is highly responsive to nutrient fluctu…
View article: Adipsin deficiency does not impact atherosclerosis development in <i>Ldlr</i><sup>−/−</sup> mice
Adipsin deficiency does not impact atherosclerosis development in <i>Ldlr</i><sup>−/−</sup> mice Open
Adipsin deficiency does not impact the development of atherosclerosis in Ldlr −/− mice despite its crucial function in alternative complement activation. Therefore, it is unlikely to play an important role in mediating the risk of atherosc…
View article: Comparative Analysis of the Mechanism of Engineering Project Management Standardization
Comparative Analysis of the Mechanism of Engineering Project Management Standardization Open
With the improvement of engineering project performance and the need for theoretical innovation, the importance of standardized research on engineering project management has become increasingly important. Based on the results of the quest…
View article: Research on Performance and Decision-making Method of Project Management Mode
Research on Performance and Decision-making Method of Project Management Mode Open
Aiming at the research of project management mode performance and decision-making method, this paper adopts the method of expert group decision-making. Group decision-making is to give full play to the wisdom of the collective. First, expe…
View article: PPARy deacetylation confers the anti-atherogenic effect and improves endothelial function in diabetes treatment
PPARy deacetylation confers the anti-atherogenic effect and improves endothelial function in diabetes treatment Open
Cardiovascular disease (CVD) is the leading cause of death in diabetic patients; however, tight glycemic control fails to lower the risk. The thiazolidinediones (TZDs), a class of PPARg agonists, are potent insulin sensitizers with anti-at…
View article: PPARy deacetylation confers the anti-atherogenic effect and improves endothelial function in diabetes treatment
PPARy deacetylation confers the anti-atherogenic effect and improves endothelial function in diabetes treatment Open
Cardiovascular disease (CVD) is the leading cause of death in diabetic patients; however, tight glycemic control fails to lower the risk. The thiazolidinediones (TZDs), a class of PPARg agonists, are potent insulin sensitizers with anti-at…
View article: PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment
PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment Open
Cardiovascular disease (CVD) is the leading cause of death in patients with diabetes, and tight glycemic control fails to reduce the risk of developing CVD. Thiazolidinediones (TZDs), a class of peroxisome proliferator–activated receptor γ…
View article: Identification of a natural beige adipose depot in mice
Identification of a natural beige adipose depot in mice Open
Beige fat is a potential therapeutic target for obesity and other metabolic diseases due to its inducible brown fat-like functions. Inguinal white adipose tissue (iWAT) can undergo robust brown remodeling with appropriate stimuli and is th…
View article: The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity
The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity Open
Fat remodeling has been extensively explored through protein deacetylation, but not yet acetylation, as a viable therapeutic approach in the management of obesity and related metabolic disorders. Here, we investigated the functions of key …
View article: FoxO1 in the regulation of adipocyte autophagy and biology
FoxO1 in the regulation of adipocyte autophagy and biology Open
Obesity is a rapidly growing epidemic in the USA and worldwide. While the molecular and cellular mechanism of obesity is incompletely understood, studies have shown that excess adiposity may arise from increased adipogenesis (hyperplasia) …
View article: FoxO1 interacts with transcription factor EB and differentially regulates mitochondrial uncoupling proteins via autophagy in adipocytes
FoxO1 interacts with transcription factor EB and differentially regulates mitochondrial uncoupling proteins via autophagy in adipocytes Open
Mitochondrial uncoupling proteins (UCPs) are inducible and play an important role in metabolic and redox homeostasis. Recent studies have suggested that FoxO1 controls mitochondrial biogenesis and morphology, but it remains largely unknown…
View article: FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes
FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes Open
Obesity and related metabolic disorders constitute one of the most pressing heath concerns worldwide. Increased adiposity is linked to autophagy upregulation in adipose tissues. However, it is unknown how autophagy is upregulated and contr…
View article: Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein‐1 and Implication for Breast Cancer Treatment
Coordinated Upregulation of Mitochondrial Biogenesis and Autophagy in Breast Cancer Cells: The Role of Dynamin Related Protein‐1 and Implication for Breast Cancer Treatment Open
Overactive mitochondrial fission was shown to promote cell transformation and tumor growth. It remains elusive how mitochondrial quality is regulated in such conditions. Here, we show that upregulation of mitochondrial fission protein, dyn…
View article: FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes
FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes Open
Obesity and related metabolic disorders constitute one of the most pressing heath concerns worldwide. Increased adiposity is linked to autophagy upregulation in adipose tissues. However, it is unknown how autophagy is upregulated and contr…
View article: Xiaokening stimulates endothelial nitric oxide release in diabetic rats
Xiaokening stimulates endothelial nitric oxide release in diabetic rats Open
Xiaokening was able to significantly increase NO release and improve the endothelial function of mesenteric arterioles through antioxidative mechanisms.
View article: Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans
Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans Open
The reduction of mtDNAn in obese human subjects is associated with insulin resistance and may arise from increased D-loop methylation, suggesting an insulin signaling-epigenetic-genetic axis in mitochondrial regulation.
View article: Tamoxifen reduces fat mass by boosting reactive oxygen species
Tamoxifen reduces fat mass by boosting reactive oxygen species Open
As the pandemic of obesity is growing, a variety of animal models have been generated to study the mechanisms underlying the increased adiposity and development of metabolic disorders. Tamoxifen (Tam) is widely used to activate Cre recombi…
View article: Targeting FoxO1 with AS1842856 Suppresses Adipogenesis
Targeting FoxO1 with AS1842856 Suppresses Adipogenesis Open
Hyperplasia (i.e., increased adipogenesis) contributes to excess adiposity, the hallmark of obesity that can trigger metabolic complications. As FoxO1 has been implicated in adipogenic regulation, we investigated the kinetics of FoxO1 acti…