Longkai Peng
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View article: TREM1 deficiency attenuates LPS-induced sepsis-associated acute kidney injury by modulating macrophage polarization
TREM1 deficiency attenuates LPS-induced sepsis-associated acute kidney injury by modulating macrophage polarization Open
Background: Sepsis-associated acute kidney injury (SA-AKI) drives high mortality in sepsis. The triggering receptor expressed on myeloid cells-1 (TREM1) plays critical roles in both infectious and non-infectious pathologies. However, the r…
View article: Association between drinking water type and kidney stone risk in U.S. adults: a cross-sectional analysis of NHANES 2009–2016 data
Association between drinking water type and kidney stone risk in U.S. adults: a cross-sectional analysis of NHANES 2009–2016 data Open
Purpose: While fluid intake and trace elements are known to influence kidney stone risk, the impact of drinking water type remains unclear. This study aimed to systematically evaluate the association between water source and kidney stone p…
View article: Comparison of pathogen detection performance between metagenomic next-generation sequencing and conventional culture in organ preservation fluids and recipient wound drainage fluids
Comparison of pathogen detection performance between metagenomic next-generation sequencing and conventional culture in organ preservation fluids and recipient wound drainage fluids Open
Background Prompt identification and management of donor-derived infections post-kidney transplantation are critical. This study aims to assess the effectiveness of metagenomic next-generation sequencing (mNGS) in detecting pathogens withi…
View article: Clinical outcomes of kidney transplantation from expanded-criteria donors and KDPI>85% kidneys in deceased Chinese donors
Clinical outcomes of kidney transplantation from expanded-criteria donors and KDPI>85% kidneys in deceased Chinese donors Open
View article: The role and mechanism of TSC in kidney diseases: a literature review
The role and mechanism of TSC in kidney diseases: a literature review Open
View article: Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning, and SHAP methods for comprehensive analysis
Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning, and SHAP methods for comprehensive analysis Open
NAAG plays a protective role in graft dysfunction, and part of the effect is mediated by inhibition of IL-2RB, which is verified as an important gene that functions in transplant kidney rejection. NAAG and IL-2RB may be novel molecular mar…
View article: A comparative study of clinical outcomes and risk factors of tuberculosis in kidney transplant recipients from deceased donors
A comparative study of clinical outcomes and risk factors of tuberculosis in kidney transplant recipients from deceased donors Open
View article: VSIG4 as a novel immune-related diagnostic biomarker and therapeutic target in renal fibrosis
VSIG4 as a novel immune-related diagnostic biomarker and therapeutic target in renal fibrosis Open
VSIG4 is highly expressed in UUO and may be an important mediator involved in renal fibrosis.
View article: A Comparative Study of Clinical Outcomes and Risk Factors of Tuberculosis in Kidney Transplant Recipients from Deceased Donors
A Comparative Study of Clinical Outcomes and Risk Factors of Tuberculosis in Kidney Transplant Recipients from Deceased Donors Open
Objective: To investigate the clinical characteristics, diagnosis and treatment of tuberculosis infection after deceased donor kidney transplantation and to analyze the risk factors and prognosis of tuberculosis infection through a paired …
View article: TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice
TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice Open
View article: Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival
Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival Open
Background: T cell dysfunction, which includes exhaustion, anergy, and senescence, is a distinct T cell differentiation state that occurs after antigen exposure. Although T cell dysfunction has been a cornerstone of cancer immunotherapy, i…
View article: Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target
Role of triggering receptor expressed on myeloid cells-1 in kidney diseases: A biomarker and potential therapeutic target Open
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation…
View article: Mouse kidney transplantation model: Three novel methods.
Mouse kidney transplantation model: Three novel methods. Open
All 3 surgical methods are able to successfully establish mouse kidney transplantation models, with no significant differences observed in the short-term graft survival and acute rejection. The modified abdominal suture technique and abdom…
View article: Preexisting renal graft dysfunction as a major risk factor for SARS-CoV-2 Omicron variant pneumonia: A postinfection cross-sectional study of 312 immunosuppressed renal transplant recipients
Preexisting renal graft dysfunction as a major risk factor for SARS-CoV-2 Omicron variant pneumonia: A postinfection cross-sectional study of 312 immunosuppressed renal transplant recipients Open
Preexisting renal graft dysfunction was a major risk factor for SARS-CoV-2 Omicron variant pneumonia. It is suggested that high-risk renal transplant recipients should undergo computed tomography scanning within 14 days after infection wit…
View article: Cd5l Up-Regulate the Tgf-Β Signaling Pathway and Promote Renal Fibrosis
Cd5l Up-Regulate the Tgf-Β Signaling Pathway and Promote Renal Fibrosis Open
View article: CD5L Up-Regulate the TGF-β Signaling Pathway and Promote Renal Fibrosis
CD5L Up-Regulate the TGF-β Signaling Pathway and Promote Renal Fibrosis Open
View article: Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model
Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model Open
Background: Homoharringtonine (HHT) is an effective anti-inflammatory, anti-viral, and anti-tumor protein synthesis inhibitor that has been applied clinically. Here, we explored the therapeutic effects of HHT in a mouse heart transplant mo…
View article: Clinical outcomes for kidney transplantation in 81 adults with IgA nephropathy.
Clinical outcomes for kidney transplantation in 81 adults with IgA nephropathy. Open
Renal transplantation for adults with IgAN had a remarkable short-term effect. The recipients can be beneficial significantly to favorable midium- and long-term outcomes. IgAN recurrence is infrequent and rarely causes severe renal functio…
View article: Hemophagocytic lymphohistiocytosis secondary to virus infection and followed by lupus nephritis recurrence in a renal transplantation pediatric recipient: a case report
Hemophagocytic lymphohistiocytosis secondary to virus infection and followed by lupus nephritis recurrence in a renal transplantation pediatric recipient: a case report Open
View article: Excellent clinical outcomes of renal transplant from pediatric deceased donors with acute kidney injury
Excellent clinical outcomes of renal transplant from pediatric deceased donors with acute kidney injury Open
Background The use of kidneys from deceased donors with acute kidney injury (AKI) to expand the donor pool is an ongoing trend. Prior research on the utilization of AKI donor kidneys, especially from pediatric AKI donors, was limited and h…
View article: Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients
Association and prediction of red blood cell distribution width to albumin ratio in all-cause mortality of acute kidney injury in critically ill patients Open
Aim The progression of acute kidney injury (AKI) might be associated with systemic inflammation. Our study aims to explore the association and predictive value of the red blood cell distribution width (RDW) to human serum albumin (ALB) rat…
View article: Excellent Clinical Outcomes of Renal Transplant from Pediatric Deceased Donors with Acute Kidney Injury
Excellent Clinical Outcomes of Renal Transplant from Pediatric Deceased Donors with Acute Kidney Injury Open
Background: The use of kidneys from deceased donors with acute kidney injury (AKI) to expand the donor pool is an ongoing trend. Prior research on the utilization of AKI donor kidneys, especially from pediatric AKI donors, was limited and …
View article: Short-term outcome of kidney transplantation from deceased donors with nephrolithiasis.
Short-term outcome of kidney transplantation from deceased donors with nephrolithiasis. Open
The cadaveric kidney allografts with nephrolithiasis could be safely used for transplantation, and the short-term outcome is acceptable. However, nephrolithiasis in donors may increase the rate of kidney discard, disturb the short-term fun…
View article: Drug-induced Fanconi syndrome in patients with kidney allograft transplantation
Drug-induced Fanconi syndrome in patients with kidney allograft transplantation Open
Background Patients after kidney transplantation need to take long-term immunosuppressive and other drugs. Some of these drug side effects are easily confused with the symptoms of Fanconi syndrome, resulting in misdiagnosis and missed diag…
View article: Utilization of HCV Viremic Kidneys with Genotyping/Subtyping‐Free Sofosbuvir/Velpatasvir Treatment Strategy: Experience from China
Utilization of HCV Viremic Kidneys with Genotyping/Subtyping‐Free Sofosbuvir/Velpatasvir Treatment Strategy: Experience from China Open
Background . Owing to the advent of pangenotypic direct‐acting antiviral agents (DAAs) for hepatitis C virus (HCV) treatment, utilization of HCV‐infected deceased donor kidneys with simplified genotyping/subtyping‐free sofosbuvir/velpatasv…
View article: Comparison of Outcomes of Kidney Transplantation From Extremely Low Body Weight ≤5kg Versus Larger Body Weight Pediatric Donors
Comparison of Outcomes of Kidney Transplantation From Extremely Low Body Weight ≤5kg Versus Larger Body Weight Pediatric Donors Open
Background Kidney transplantation from donors who weigh ≤5 kg is performed at only a few transplant centers owing to the high complication and low graft survival rates associated with this approach. Methods We retrospectively compared the …
View article: The Role of Regulatory B cells in Kidney Diseases
The Role of Regulatory B cells in Kidney Diseases Open
B cells, commonly regarded as proinflammatory antibody-producing cells, are detrimental to individuals with autoimmune diseases. However, in recent years, several studies have shown that regulatory B (Breg) cells, an immunosuppressive subs…
View article: Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection
Single-cell analysis of angiotensin-converting enzyme II expression in human kidneys and bladders reveals a potential route of 2019 novel coronavirus infection Open
Background: Since 2019, a novel coronavirus named 2019 novel coronavirus (2019-nCoV) has emerged worldwide. Apart from fever and respiratory complications, acute kidney injury has been observed in a few patients with coronavirus disease 20…
View article: The Relationship Between Blood Interleukin-10 and Cardiovascular Mortality and All-Cause Mortality After Kidney Transplantation
The Relationship Between Blood Interleukin-10 and Cardiovascular Mortality and All-Cause Mortality After Kidney Transplantation Open
Plasma IL-10 is independently and significant associated with cardiovascular and all-cause mortality after kidney transplantation. The significant association is independent of cardiovascular risk factors and other related confounding fact…
View article: Cost-effectiveness analysis of pembrolizumab plus chemotherapy as first-line therapy for extensive-stage small-cell lung cancer
Cost-effectiveness analysis of pembrolizumab plus chemotherapy as first-line therapy for extensive-stage small-cell lung cancer Open
Background The phase III KEYNOTE-604 study confirmed the benefit of pembrolizumab combined with chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer (ES-SCLC). Taken into account the clinical benefits of pembr…