Longlong Fu
YOU?
Author Swipe
View article: Triclocarban impacts human sperm motility by inhibiting glycolysis and oxidative phosphorylation
Triclocarban impacts human sperm motility by inhibiting glycolysis and oxidative phosphorylation Open
Triclocarban (TCC) is a broad-spectrum antimicrobial widely used in various personal care products, textiles, and children’s toys. TCC has potential reproductive and developmental toxicity in animals. However, little is known regarding the…
View article: GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis
GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis Open
GM-CSF supports the maintenance of the proinflammatory nature of RA monocyte-derived macrophages, driving CCL22-mediated T cell responses. This study highlights the GM-CSF/CCL22 axis as a pathogenic mechanism in RA and suggests CCL22 as a …
View article: Impact of different food sources on nutrient profile and taste attributes of Chinese mitten crab (Eriocheir sinensis)
Impact of different food sources on nutrient profile and taste attributes of Chinese mitten crab (Eriocheir sinensis) Open
In recent years, to decrease costs for crab fattening, enterprises and farmers gradually use animal offals like beef liver to replace with frozen fish. However, the potential and limitations of such substitute feeds require systematic rese…
View article: Identification of hub genes associated with decreased fertility in male mice of advanced paternal age
Identification of hub genes associated with decreased fertility in male mice of advanced paternal age Open
Introduction Aging and delayed parenthood are major social concerns. Men older than 35 years, which is an advanced paternal age, experience reduced sperm quality and fertility. Methods In this study, 12-month-old mice served as a model for…
View article: Morphological Parameters of 29994 sperm in a fertile male population—based on Papanicolaou staining and SSA-II Plus
Morphological Parameters of 29994 sperm in a fertile male population—based on Papanicolaou staining and SSA-II Plus Open
Objective This study aims to provide reference data for sperm morphology in a healthy, fertile male population providing a foundation for future studies on male infertility assessment and sperm selection in assisted reproductive technologi…
View article: Synthesis and antitumor activity of steroid-based imidazolium salts
Synthesis and antitumor activity of steroid-based imidazolium salts Open
Thirty-six novel steroid-imidazolium salts were synthesized, and compound 12f exhibited potent cytotoxicity with its mechanism studied.
View article: Seminal plasma microbiomes, sperm parameters, and cryopreservation in a healthy fertile population
Seminal plasma microbiomes, sperm parameters, and cryopreservation in a healthy fertile population Open
Background Recent advances in microbiome research have revealed the presence of diverse microbial communities in human tissues previously thought to be sterile. The present study delves into the emerging field of seminal plasma microbiomic…
View article: Dietary monosodium glutamate affects the growth and feed utilization of Eriocheir sinensis by regulating the appetite related genes expression
Dietary monosodium glutamate affects the growth and feed utilization of Eriocheir sinensis by regulating the appetite related genes expression Open
This study assessed the impacts of monosodium glutamate (MSG) on the growth performance, feed utilization, feed intake, and appetite regulation of Chinese mitten crab, Eriocheir sinensis. A total of 240 juvenile crabs (9.16 ± 0.21 g) were …
View article: Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective Additive
Enhancement of Frozen-Thawed Human Sperm Quality with Zinc as a Cryoprotective Additive Open
BACKGROUND Cryopreservation preserves male fertility, crucial in oncology, advanced age, and infertility. However, it damages sperm motility, membrane, and DNA. Zinc (Zn), an antioxidant, shows promise in improving sperm quality after thaw…
View article: Combined Analysis of the Transcriptome, Proteome and Metabolome in Human Cryopreserved Sperm
Combined Analysis of the Transcriptome, Proteome and Metabolome in Human Cryopreserved Sperm Open
Five genes were identified by multiomics analysis in human cryopreserved sperm. These genes might have specific functions in cryopreservation. Explorations of the functions of these genes will be helpful for sperm cryopreservation and sper…
View article: The current situation of semen analysis in China, based on a survey of 296 laboratories
The current situation of semen analysis in China, based on a survey of 296 laboratories Open
Dear Editor, Semen analysis is a basic test to assess male fertility and is a fundamental test in assisted reproductive technology. From the first publication of World Health Organization (WHO) Laboratory Manual of Human Semen and Sperm-Ce…
View article: Novel biallelic variants in <i>DNAH1</i> cause multiple morphological abnormalities of sperm flagella with favorable outcomes of fertility after ICSI in Han Chinese males
Novel biallelic variants in <i>DNAH1</i> cause multiple morphological abnormalities of sperm flagella with favorable outcomes of fertility after ICSI in Han Chinese males Open
Background Multiple morphological abnormalities of sperm flagella is an idiopathic asthenoteratozoospermia characterized by absent, short, coiled, angulation, and irregular‐caliber flagella. Genetic variants of DNAH1 gene have been identif…
View article: O-253 Novel biallelic variants in DNAH1 cause multiple morphological abnormalities of sperm flagella with favorable outcomes of fertility after ICSI in Han Chinese males
O-253 Novel biallelic variants in DNAH1 cause multiple morphological abnormalities of sperm flagella with favorable outcomes of fertility after ICSI in Han Chinese males Open
Study question Is there any novel variants and mutant hotspot in DNAH1 gene related to multiple morphological abnormalities of sperm flagella (MMAF) and male infertility in humans? Summary answer We identified eighteen variants of DNAH1 ge…
View article: Predictive Value of Liver Dysfunction Symptom Cluster on Compliance with TACE Treatment for Liver Cancer
Predictive Value of Liver Dysfunction Symptom Cluster on Compliance with TACE Treatment for Liver Cancer Open
Objective: To investigate the predictive value of liver dysfunction symptom cluster on compliance with transcatheter arterial chemoembolization (TACE) in patients with primary liver cancer. Methods: The Symptom Module Specific to Primary L…
View article: Insufficiency of Mrpl40 disrupts testicular structure and semen parameters in a murine model
Insufficiency of Mrpl40 disrupts testicular structure and semen parameters in a murine model Open
Approximately 31% of patients with 22q11.2 deletion syndrome (22q11.2DS) have genitourinary system disorders and 6% of them have undescended testes. Haploinsufficiency of genes on chromosome 22q11.2 might contribute to the risk of 22q11.2D…
View article: Determination of Parabens and Their Metabolites in Seminal Plasma from Chinese Men by Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS)
Determination of Parabens and Their Metabolites in Seminal Plasma from Chinese Men by Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS) Open
Parabens are endocrine-disrupting chemicals (EDCs) that have estrogen-like activities and may cause male reproductive disorders. Here, we developed a method for the simultaneous determination of four parabens (MeP, EtP, n-PrP, n-BuP) and t…
View article: Molecular dominance investigation for large-sized parents&nbsp;of Chinese Mitten Crab ( Eriocheir sinensis ) based on&nbsp;ovarian transcriptome
Molecular dominance investigation for large-sized parents of Chinese Mitten Crab ( Eriocheir sinensis ) based on ovarian transcriptome Open
Background: Germplasm degradation is one of the important issues for the healthy development of Chinese Mitten Crab ( Eriocheir sinensis ) industry. Nowadays, nursery units and crab farmers have realized the seedling superiority of large-s…
View article: Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia
Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia Open
s Background Qilin pills (QLPs), a classic Traditional Chinese Medicine (TCM) formula for treating male infertility, effectively improve semen quality in clinical trials. This study was designed to evaluate the effects of QLPs on spermatog…
View article: The impact of exogenous testosterone supplementation on spermatogenesis in a rat model of oligoasthenospermia.
The impact of exogenous testosterone supplementation on spermatogenesis in a rat model of oligoasthenospermia. Open
Oligoasthenospermia is one of the main causes of infertility in reproductive-age men. This study aimed to explore the feasibility of exogenous testosterone supplemental therapy (TST) for adult male rats with oligoasthenospermia model. The …
View article: Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry
Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry Open
Background Human sperm cryopreservation is a simple and effective approach for male fertility preservation. Methods To identify potential proteomic changes in this process, data-independent acquisition (DIA), a technology with high quantit…
View article: Sperm Cryopreservation for Male Cancer Patients: More than 10 Years of Experience, in Beijing China
Sperm Cryopreservation for Male Cancer Patients: More than 10 Years of Experience, in Beijing China Open
BACKGROUND Fertility preservation is very important for male cancer patients, especially adolescents. Unfortunately, the use of fertility preservation is very low among Chinese male cancer patients. Additionally, the cumulative rate of fro…
View article: MOESM2 of Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry
MOESM2 of Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry Open
Additional file 2: Table S2. The results of the GO enrichment.
View article: Glycolysis metabolic changes in sperm cryopreservation based on a targeted metabolomic strategy.
Glycolysis metabolic changes in sperm cryopreservation based on a targeted metabolomic strategy. Open
Our aim was to identify potential metabolomic pathway changes in the sperm cryopreservation process and to find new markers of human sperm freezability. Targeted metabolomic experiments were used to identify the quantitative metabolomic co…
View article: In human sperm nucleus nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning
In human sperm nucleus nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning Open
In human sperm, a fraction of its chromatin retains nucleosomes that are positioned on specific sequences containing genes and regulatory units essential for embryonic development. This nucleosome positioning (NP) feature provides an inher…
View article: MOESM1 of Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry
MOESM1 of Quantitative proteomic characterization of human sperm cryopreservation: using data-independent acquisition mass spectrometry Open
Additional file 1: Table S1. The differential proteins due to cryopreservtaion.
View article: Human sperm chromatin forms spatially restricted nucleosome domains consistent with programmed nucleosome positioning
Human sperm chromatin forms spatially restricted nucleosome domains consistent with programmed nucleosome positioning Open
In human sperm, a fraction of its chromatin retains nucleosomes that are positioned on specific sequences containing genes and regulatory units essential for embryonic development. This nucleosome positioning (NP) feature provides an inher…
View article: Qilin pills alleviate oligoasthenospermia by inhibiting Bax-caspase-9 apoptosis pathway in the testes of model rats
Qilin pills alleviate oligoasthenospermia by inhibiting Bax-caspase-9 apoptosis pathway in the testes of model rats Open
At present, the treatment of oligoasthenospermia with western medicine is ineffective. Qilin pill (QLP) is a Chinese traditional medicine for treating male infertility. Recent multicenter clinical studies in China reported that QLPs marked…
View article: Effects of testosterone supplementation therapy on lipid metabolism in hypogonadal men with T2<scp>DM</scp>: a meta‐analysis of randomized controlled trials
Effects of testosterone supplementation therapy on lipid metabolism in hypogonadal men with T2<span>DM</span>: a meta‐analysis of randomized controlled trials Open
Summary Testosterone supplementation may be effective for the treatment of hypogonadism in men with type 2 diabetes mellitus (T2 DM ), but the evidence from randomized controlled trials ( RCT s) is inconclusive. We aimed to systematically …