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View article: Optogenetically enhanced physical reservoir computing with in vitro neural networks for obstacle avoidance
Optogenetically enhanced physical reservoir computing with in vitro neural networks for obstacle avoidance Open
The results highlight the potential of optogenetically controlled biological neural networks in neuro-robotic systems, showcasing their capability to achieve accurate and efficient obstacle avoidance through physical reservoir computing.
View article: Predictive Accuracy of a Clinical Model for Carriage of Pathogenic/Likely Pathogenic Variants in Patients with Dementia and a Positive Family History at PUMCH
Predictive Accuracy of a Clinical Model for Carriage of Pathogenic/Likely Pathogenic Variants in Patients with Dementia and a Positive Family History at PUMCH Open
Background and Objectives: Identifying carriers of Pathogenic/Likely Pathogenic Variants in patients with dementia is crucial for risk stratification, particularly in individuals with a family history. This study developed and validated a …
View article: Discriminating Alzheimer's Pathologic Changes from Dementias: A Multi‐Factor Blood Biomarkers Diagnostic Model Using the AT(N) System
Discriminating Alzheimer's Pathologic Changes from Dementias: A Multi‐Factor Blood Biomarkers Diagnostic Model Using the AT(N) System Open
Background To assess the diagnostic efficacy of plasma biomarkers in distinguishing Alzheimer's pathologic changes from other forms of dementia, our study focused on examining plasma biomarkers in accordance with the AT(N) system. Method A…
View article: Simulation and fabrication of <i>in vitro</i> microfluidic microelectrode array chip for patterned culture and electrophysiological detection of neurons
Simulation and fabrication of <i>in vitro</i> microfluidic microelectrode array chip for patterned culture and electrophysiological detection of neurons Open
To enable the detection and modulation of modularized neural networks in vitro, this study proposes a microfluidic microelectrode array chip for the cultivation, compartmentalization, and control of neural cells. The chip was designed base…
View article: The clinical, neuropsychological and neuroimaging characters of <i>GRN</i> mutations carriers in a Chinese PUMCH dementia cohort
The clinical, neuropsychological and neuroimaging characters of <i>GRN</i> mutations carriers in a Chinese PUMCH dementia cohort Open
Background Mutations in the progranulin gene on chromosome 17( GRN ) is considered as one of most common causes of frontotemporal lobe degeneration. However, the phenotype and genotype correlation of GRN varies among different cohorts and …
View article: LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis
LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis Open
In bacteria, archaea, protists, and plants, the hydrolysis of pyrophosphate (PPi) by inorganic pyrophosphatase (PPase) can, under stress conditions, substitute for ATP-driven proton flux to generate a proton gradient and induce luminal aci…
View article: Screening and functional validations of APP, PSEN1 and PSEN2 mutations from PUMCH dementia cohort
Screening and functional validations of APP, PSEN1 and PSEN2 mutations from PUMCH dementia cohort Open
Background : Presenilin 1 ( PSEN1 ), presenilin 2 ( PSEN2 ), and amyloid precursor protein ( APP ) genes have been verified as causative genes for Alzheimer’s disease (AD). The present study aimed to (1) screen for pathogenic mutations in …
View article: CSF biomarkers for early-onset Alzheimer's disease in Chinese population from PUMCH dementia cohort
CSF biomarkers for early-onset Alzheimer's disease in Chinese population from PUMCH dementia cohort Open
Introduction Alzheimer's disease (AD) is one of the highly concerned degenerative disorders in recent decades. Though vast amount of researches has been done in various aspects, early-onset subtype, however, needs more investigation in dia…
View article: Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk
Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer’s disease risk Open
Amyloid-β (Aβ) derived from amyloid precursor protein (APP) hydrolysis is acknowledged as the predominant hallmark of Alzheimer’s disease (AD) that especially correlates to genetics and daily activities. In 2019, meta-analysis of AD has di…
View article: Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice
Pharmacological induction of AMFR increases functional EAAT2 oligomer levels and reduces epileptic seizures in mice Open
Dysregulation of excitatory amino acid transporter 2 (EAAT2) contributes to the development of temporal lobe epilepsy (TLE). Several strategies for increasing total EAAT2 levels have been proposed. However, the mechanism underlying the oli…
View article: A Neural Sensor with a Nanocomposite Interface for the Study of Spike Characteristics of Hippocampal Neurons under Learning Training
A Neural Sensor with a Nanocomposite Interface for the Study of Spike Characteristics of Hippocampal Neurons under Learning Training Open
Both the cellular- and population-level properties of involved neurons are essential for unveiling the learning and memory functions of the brain. To give equal attention to these two aspects, neural sensors based on microelectrode arrays …
View article: Effects of ApoE genotype on clinical phenotypes in early‐onset and late‐onset Alzheimer's disease in China: Data from the PUMCH dementia cohort
Effects of ApoE genotype on clinical phenotypes in early‐onset and late‐onset Alzheimer's disease in China: Data from the PUMCH dementia cohort Open
Introduction To investigate the heterogeneous effect of Apolipoprotein E (ApoE) genotype on clinical phenotypes in early‐onset Alzheimer's disease (EOAD) and late‐onset Alzheimer's disease (LOAD), respectively. Methods 785 probable AD pati…
View article: Factors related to CSF biomarkers examination in Alzheimer’s disease
Factors related to CSF biomarkers examination in Alzheimer’s disease Open
Background Cerebral spinal fluid (CSF) biomarkers was important part of AT(N) framework in Alzheimer’s disease (AD) definition. Typical AD biomarkers profile was decrease of Aβ42 and elevation of t‐tau and p‐tau in CSF. However, ELISA base…
View article: Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity Open
Rationale: Dysfunction or reduced levels of EAAT2 have been documented in epilepsy. We previously demonstrated the antiepileptic effects of Hsp90 inhibitor 17AAG in temporal lobe epilepsy by preventing EAAT2 degradation. Because of the pot…
View article: P2‐221: CEREBROSPINAL FLUID AMYLOID‐β 42, TOTAL TAU AND PHOSPHORYLATED TAU ARE DISTINCT IN PATIENTS WITH NORMAL PRESSURE HYDROCEPHALUS AND ALZHEIMER'S DISEASE
P2‐221: CEREBROSPINAL FLUID AMYLOID‐β 42, TOTAL TAU AND PHOSPHORYLATED TAU ARE DISTINCT IN PATIENTS WITH NORMAL PRESSURE HYDROCEPHALUS AND ALZHEIMER'S DISEASE Open
Previous postmortem studies revealed the frequent co-existence of Alzheimer's disease (AD) in normal pressure hydrocephalus (NPH). However, the relationship between these two diseases and the pathophysiology mechanism of NPH are still uncl…
View article: P3‐247: GENETIC ANALYSIS OF EARLY‐ONSET DEMENTIA IN CHINA
P3‐247: GENETIC ANALYSIS OF EARLY‐ONSET DEMENTIA IN CHINA Open
Early-onset dementias (EOD), which present before 65 years old, have a closer relationship with genetic factors in comparison to late-onset dementias. We aimed to investigate genetic characteristics of EOD. 196 EOD patients were retrospect…
View article: P4‐175: COGNITION AND CEREBRAL SPINAL FLUID BIOMARKERS RELATIONSHIP IN AD
P4‐175: COGNITION AND CEREBRAL SPINAL FLUID BIOMARKERS RELATIONSHIP IN AD Open
CSF biomarkers reflect the pathophysiology of AD. CSF Aβ decrease is found long before clinical cognitive decline. Aβ accumulation in brain is an aging process and no relationship was found between Aβ deposition and disease progression in …
View article: P1‐236: CEREBRAL SPINAL FLUID T‐TAU AND P‐TAU ARE USEFUL IN DIFFERENTIAL DIAGNOSIS BETWEEN ALZHEIMER'S DISEASE AND OTHER DEGENERATIVE DEMENTIA: A CHINESE SINGLE CENTER COHORT STUDY
P1‐236: CEREBRAL SPINAL FLUID T‐TAU AND P‐TAU ARE USEFUL IN DIFFERENTIAL DIAGNOSIS BETWEEN ALZHEIMER'S DISEASE AND OTHER DEGENERATIVE DEMENTIA: A CHINESE SINGLE CENTER COHORT STUDY Open
CSF biomarkers are important in the diagnosis of AD. In 2018 NIA-AA AT(N) research framework, CSF P-Tau was regarded as AD specific and T-tau was classified as neuro-injury biomarker and not AD specific, which was different from the concep…
View article: P1‐229: THE ROLE OF CEREBROSPINAL FLUID MARKERS IN CREUTZFELDT‐JAKOB DISEASE
P1‐229: THE ROLE OF CEREBROSPINAL FLUID MARKERS IN CREUTZFELDT‐JAKOB DISEASE Open
As a rare and fatal neurodegenerative disorder, Creutzfeldt-Jakob disease (CJD) has varied clinical manifestation, and share several pathophysiological features with Alzheimer's disease (AD). It is still a challenge to diagnose CJD in clin…
View article: P1‐235: CUT‐OFF VALUE IN CSF PROFILE FOR ALZHEIMER'S DISEASE DIAGNOSIS AMONG CHINESE POPULATION
P1‐235: CUT‐OFF VALUE IN CSF PROFILE FOR ALZHEIMER'S DISEASE DIAGNOSIS AMONG CHINESE POPULATION Open
Antemortem cerebrospinal fluid (CSF) biomarkers tests for early-stage Alzheimer's disease (AD) diagnosis were established and evaluated separately in a great amount of centers. But definite conclusion and cut-off values are still inconsist…
View article: P3‐218: APOE GENOTYPE IS IRRELEVANT TO CEREBRAL SPINAL FLUID BIOMARKERS IN AD
P3‐218: APOE GENOTYPE IS IRRELEVANT TO CEREBRAL SPINAL FLUID BIOMARKERS IN AD Open
ApoE genotype is a well known risk factor of AD. However, most study showed no relationship between ε4 allele and clinical phenotype. CSF biomarkers are diagnostic for AD and reflect pathophysiology of AD. Whether ApoE genotype influences …
View article: Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S Staining
Comparison of β-Amyloid Plaque Labeling Methods: Antibody Staining, Gallyas Silver Staining, and Thioflavin-S Staining Open
Objective To evaluate senile plaque formation and compare the sensitivity of three different β-amyloid (Aβ) labeling methods (antibody staining, Gallyas silver staining, and thioflavin-S staining) to detect Aβ deposition.Methods APPswe/PSE…
View article: Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy
Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy Open
The glutamate transporter GLT-1 is critical for the maintenance of low interstitial glutamate concentrations. Loss of GLT-1 is commonly observed in neurological disorders, including temporal lobe epilepsy (TLE). Despite the hypothesis that…