Explanipedia

A call to action to advance patient‐focused and decentralized clinical trials Open

R. Donald Harvey, Therica M. Miller, Patricia A. Hurley, Ramya Thota, Lora Black , et al. · 2024

This commentary is a call to action for a concerted commitment and effort to transform clinical trials and enable people with cancer to participate in clinical trials closer to home. Three key strategies are identified to address major bar…

Author Correction: Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial Open

Kenneth Mautner, Michael B. Gottschalk, Scott D. Boden, Alison Akard, Won C. Bae , et al. · 2023

Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial Open

Kenneth Mautner, Michael B. Gottschalk, Scott D. Boden, Won C. Bae, Lora Black , et al. · 2023

Various types of cellular injection have become a popular and costly treatment option for patients with knee osteoarthritis despite a paucity of literature establishing relative efficacy to each other or corticosteroid injections. Here we …

Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design Open

Leora I. Horwitz, Tanayott Thaweethai, Shari B. Brosnahan, Mine Cicek, Megan Fitzgerald , et al. · 2023

Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, pr…

Researching COVID to enhance recovery (RECOVER) adult study protocol: Rationale, objectives, and design Open

Leora I. Horwitz, Tanayott Thaweethai, Shari B. Brosnahan, Mine Cicek, Megan Fitzgerald , et al. · 2023

Importance SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, pr…

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection Open

Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, Emily B. Levitan, Bruce D. Levy , et al. · 2023

Importance SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID . Charact…

Towards the international interoperability of clinical research networks for rare diseases: recommendations from the IRDiRC Task Force Open

Rima Nabbout, Galliano Zanello, Dixie B. Baker, Lora Black, Isabella Brambilla , et al. · 2023

Background Many patients with rare diseases are still lacking a timely diagnosis and approved therapies for their condition despite the tremendous efforts of the research community, biopharmaceutical, medical device industries, and patient…

Additional file 2 of Towards the international interoperability of clinical research networks for rare diseases: recommendations from the IRDiRC Task Force Open

Rima Nabbout, Galliano Zanello, Dixie B. Baker, Lora Black, Isabella Brambilla , et al. · 2023

Additional file 2. This table shows the number of clinical research sites and of health care providers institution for each CRN that answered the survey and that was included in this study. The search was performed on the websites of the C…

Phase II study of dichloroacetate, an inhibitor of pyruvate dehydrogenase, in combination with chemoradiotherapy for unresected, locally advanced head and neck squamous cell carcinoma Open

Steven Powell, Miroslaw Mazurczak, Elie G. Dib, Jonathon S. Bleeker, L. Geeraerts , et al. · 2022

Phase II Study of Dichloroacetate (DCA) in Combination with Chemoradiotherapy for Unresected, Locally Advanced Head and Neck Squamous Cell Carcinoma Open

Steven Powell, Miroslaw Mazurczak, Elie G. Dib, Jonathon S. Bleeker, L. Geeraerts , et al. · 2021

Background: Chemoradiotherapy (CRT) for locally-advanced head and neck squamous cell carcinoma (LA-HSNCC) yields 5-year survival rates near 50% despite causing significant toxicity. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase me…

Modeling transmission dynamics and effectiveness of worker screening programs for SARS-CoV-2 in pork processing plants Open

Kimberly VanderWaal, Lora Black, Judy Hodge, Addisalem Bedada, Scott Dee · 2021

Pork processing plants were apparent hotspots for SARS-CoV2 in the spring of 2020. As a result, the swine industry was confronted with a major occupational health, financial, and animal welfare crisis. The objective of this work was to des…

Modeling transmission dynamics and effectiveness of worker screening programs for SARS-CoV-2 in pork processing plants Open

Kimberly VanderWaal, Lora Black, Judy Hodge, Addisalem Bedada, Scott Dee · 2021

Pork processing plants were apparent hotspots for SARS-CoV2 in the spring of 2020. As a result, the swine industry was confronted with a major occupational health, financial, and animal welfare crisis. The objective of this work was to des…

Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study Open

Steven Powell, Kathryn A. Gold, Mark M. Gitau, Christopher Sumey, Michele Lohr , et al. · 2020

PURPOSE Pembrolizumab is a humanized monoclonal antibody that blocks interaction between programmed death receptor-1 (PD-1) and its ligands (PD-L1, PD-L2). Although pembrolizumab is approved for recurrent/metastatic head and neck squamous …

Making Ethics Education Matter: A Novel Approach for Enhancing Ethics Education in a Medical School Open

Ann Freeman Cook, Gretchen Spars, Lora Black, Mark Beard, Jerome W Freeman · 2019

This article was migrated. The article was not marked as recommended. Basic instruction in medical ethics has been viewed as an important component of medical education for more than three decades. However, the logistics of determining whe…

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