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View article: Bridging-mediated compaction of mitotic chromosomes
Bridging-mediated compaction of mitotic chromosomes Open
Within living cells, chromosome shapes undergo a striking morphological transition, from loose and uncondensed fibers during interphase to compacted and cylindrical structures during mitosis. ATP driven loop extrusion performed by a specia…
View article: Bridging condensins mediate compaction of mitotic chromosomes
Bridging condensins mediate compaction of mitotic chromosomes Open
Eukaryotic chromosomes compact during mitosis into elongated cylinders—and not the spherical globules expected of self-attracting long flexible polymers. This process is mainly driven by condensin-like proteins. Here, we present Brownian-d…
View article: Bridging-mediated compaction of mitotic chromosomes
Bridging-mediated compaction of mitotic chromosomes Open
SUMMARY Eukaryotic chromosomes compact during mitosis and meiosis into elongated cylinders – and not the spherical globules expected of self-attracting long flexible polymers. This process is mainly driven by condensin-like proteins. Here,…
View article: The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress
The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress Open
Human cells lacking RIF1 are highly sensitive to replication inhibitors, but the reasons for this sensitivity have been enigmatic. Here, we show that RIF1 must be present both during replication stress and in the ensuing recovery period to…
View article: Author response: The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress
Author response: The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Human cells lacking RIF1 are highly sensit…
View article: A RIF1/KAP1-based toggle switch stabilises the identities of the inactive and active X chromosomes during X inactivation
A RIF1/KAP1-based toggle switch stabilises the identities of the inactive and active X chromosomes during X inactivation Open
The onset of random X inactivation in mouse requires the switch from a symmetric to an asymmetric state, where the identities of the future inactive and active X chromosomes are assigned. Here we show that RIF1 and KAP1 are two fundamental…
View article: Common fragile sites are characterised by faulty condensin loading after replication stress
Common fragile sites are characterised by faulty condensin loading after replication stress Open
Cells coordinate interphase to mitosis transition but recurrent cytogenetic lesions appear at common fragile sites (CFSs) in a tissue-specific manner following replication stress, marking regions of instability in cancer. Despite such a di…
View article: Investigating transcription, replication and chromatin structure in determining common fragile site instability
Investigating transcription, replication and chromatin structure in determining common fragile site instability Open
Common fragile sites are a set of genomic locations with a propensity to form
\nlesions, breaks and gaps on mitotic chromosomes upon induction of replication
\nstress. While the exact reasons for their fragility are unknown, CFS display in…