Lora Khatib
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View article: Personalised whole-body modelling links gut microbiota to metabolic perturbations in Alzheimer’s disease
Personalised whole-body modelling links gut microbiota to metabolic perturbations in Alzheimer’s disease Open
The human gut microbiome has been linked to metabolic disturbances in Alzheimer’s disease (AD). However, the mechanisms by which gut microbes might influence metabolic dysfunction in AD remain poorly understood. Previously, we used constra…
View article: Chronological age estimation from human microbiomes with transformer-based Robust Principal Component Analysis
Chronological age estimation from human microbiomes with transformer-based Robust Principal Component Analysis Open
Deep learning for microbiome analysis has shown potential for understanding microbial communities and human phenotypes. Here, we propose an approach, Transformer-based Robust Principal Component Analysis(TRPCA), which leverages the strengt…
View article: A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population
A three-country analysis of the gut microbiome indicates taxon associations with diet vary by taxon resolution and population Open
Emerging research suggests that diet plays a vital role in shaping the composition and function of the gut microbiota. Although substantial efforts have been made to identify general patterns linking diet to the gut microbiome, much of thi…
View article: The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids Open
N-Acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N-acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference spe…
View article: Gut microbiome features associate with cognitive scores in individuals at risk for Alzheimer’s disease
Gut microbiome features associate with cognitive scores in individuals at risk for Alzheimer’s disease Open
Background Gut microbiome features have been linked with many diseases including Alzheimer’s disease (AD). Evidence suggests that the gut microbiota may impact cognition of AD patients. We explored the association of gut microbiota and thr…
View article: Gut microbiome features co‐occur in different groups of Alzheimer’s disease phenotypes and genotypes
Gut microbiome features co‐occur in different groups of Alzheimer’s disease phenotypes and genotypes Open
Background Gut microbiome features are known to be different in Alzheimer’s disease (AD) patients compared with cognitively normal. Evidence suggests that the gut microbiota may be related to the pathology of AD. We examined the associatio…
View article: The microbiome diversifies<i>N</i>-acyl lipid pools - including short-chain fatty acid-derived compounds
The microbiome diversifies<i>N</i>-acyl lipid pools - including short-chain fatty acid-derived compounds Open
N -acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N -acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference s…
View article: Empirically establishing drug exposure records directly from untargeted metabolomics data
Empirically establishing drug exposure records directly from untargeted metabolomics data Open
Despite extensive efforts, extracting information on medication exposure from clinical records remains challenging. To complement this approach, we developed the tandem mass spectrometry (MS/MS) based GNPS Drug Library. This resource integ…
View article: Gut microbiome compositional and functional features associate with Alzheimer’s disease pathology
Gut microbiome compositional and functional features associate with Alzheimer’s disease pathology Open
BACKGROUND The gut microbiome is a potentially modifiable factor in Alzheimer’s disease (AD); however, understanding of its composition and function regarding AD pathology is limited. METHODS Shallow-shotgun metagenomic data was used to an…
View article: Measures of empathy and compassion: A scoping review
Measures of empathy and compassion: A scoping review Open
Evidence to date indicates that compassion and empathy are health-enhancing qualities. Research points to interventions and practices involving compassion and empathy being beneficial, as well as being salient outcomes of contemplative pra…
View article: WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity
WITHDRAWN: I feel your pain: Higher empathy is associated with higher posterior default mode network activity Open
Withdrawal Statement The authors discovered an error in the primary analysis and have withdrawn the results from this version of the investigation.
View article: Development and initial validation of a mathematics-specific spatial vocabulary scale
Development and initial validation of a mathematics-specific spatial vocabulary scale Open
This study describes the development and initial validation of a mathematics-specific spatial vocabulary measure for upper elementary school students. Reviews of spatial vocabulary items, mathematics textbooks, and Mathematics Common Core …
View article: The Effects of Mindfulness-Based Stress Reduction on Trauma in Victims of Gun Violence: a Pilot Study
The Effects of Mindfulness-Based Stress Reduction on Trauma in Victims of Gun Violence: a Pilot Study Open
Objectives Gun violence is a significant problem in the United States of America. Gun violence produces lifelong psychological adversity, trauma, and grief. In the face of this epidemic, efficacious therapies that assuage gun violence-base…