Lore Vanderbeke
YOU?
Author Swipe
View article: Influenza-associated invasive aspergillosis in the ICU: a prospective, multicentre cohort study
Influenza-associated invasive aspergillosis in the ICU: a prospective, multicentre cohort study Open
View article: Influenza-associated and COVID-19-associated pulmonary aspergillosis in critically ill patients
Influenza-associated and COVID-19-associated pulmonary aspergillosis in critically ill patients Open
View article: Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis
Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis Open
Rationale: The influence of the lung bacterial microbiome, including potential pathogens, in patients with influenza-associated pulmonary aspergillosis (IAPA) or coronavirus disease (COVID-19)-associated pulmonary aspergillosis (CAP…
View article: Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study
Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study Open
Research Foundation Flanders, KU Leuven, UZ Leuven, VIB, the Fundação para a Ciência e a Tecnologia, the European Regional Development Fund, la Caixa Foundation, the Flemish Government, and Horizon 2020.
View article: High Burden of COVID-19-Associated Pulmonary Aspergillosis in Severely Immunocompromised Patients Requiring Mechanical Ventilation
High Burden of COVID-19-Associated Pulmonary Aspergillosis in Severely Immunocompromised Patients Requiring Mechanical Ventilation Open
Background Coronavirus disease 2019 (COVID-19)–associated pulmonary aspergillosis (CAPA) is a frequent superinfection in critically ill patients with COVID-19 and is associated with increased mortality rates. The increasing proportion of s…
View article: A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue
A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue Open
Rationale: Invasive pulmonary aspergillosis has emerged as a frequent coinfection in severe coronavirus disease (COVID-19), similarly to influenza, yet the clinical invasiveness is more debated. Objectives: We investigated th…
View article: C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps
C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps Open
Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that complement component 5a (C5a), through its cellular receptor C5aR…
View article: A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis
A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis Open
View article: 478. Lung Hybrid Neutrophils and Subsequent Extracellular Traps Are Protective In COVID-19-Associated Pulmonary Aspergillosis
478. Lung Hybrid Neutrophils and Subsequent Extracellular Traps Are Protective In COVID-19-Associated Pulmonary Aspergillosis Open
Background COVID-19-associated pulmonary aspergillosis (CAPA) is a severe superinfection with the fungus Aspergillus frequently affecting critically ill COVID-19 patients. Pathophysiological insight, key to improve diagnostic and immunomod…
View article: Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates
Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates Open
COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we analysed the phenotype and activity of NK cells …
View article: S3.3d Influenza versus COVID-19-associated pulmonary aspergillosis: Profiling lower respiratory tract epithelial and myeloid innate immunity in patient samples
S3.3d Influenza versus COVID-19-associated pulmonary aspergillosis: Profiling lower respiratory tract epithelial and myeloid innate immunity in patient samples Open
S3.3 Innate immune responses to pathogenic fungi, September 21, 2022, 4:45 PM - 6:15 PM Objectives Up to 20% and 15% of critically ill influenza and coronavirus disease 2019 (COVID-19) patients are affected by influenza- and COVID-19-assoc…
View article: Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study
Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study Open
View article: Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology
Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology Open
Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that complement component 5a (C5a), through its cellular receptor C5aR…
View article: Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA‐FLU study
Exposure to intravenous posaconazole in critically ill patients with influenza: A pharmacokinetic analysis of the POSA‐FLU study Open
Background Data on posaconazole in the critically ill are scarce. In the POSA‐FLU study, we examined the prevention of influenza‐associated pulmonary aspergillosis with posaconazole in this population. Methods In this observational sub‐stu…
View article: Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis
Longitudinal multimodal imaging-compatible mouse model of triazole-sensitive and -resistant invasive pulmonary aspergillosis Open
Invasive pulmonary aspergillosis (IPA) caused by the mold Aspergillus fumigatus is one of the most important life-threatening infections in immunocompromised patients. The alarming increase of isolates resistant to the first-line recommend…
View article: Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza
Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza Open
Neutrophils are recognized as important circulating effector cells in the pathophysiology of severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs is incompletely understood. Here, we collected bronchoal…
View article: Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host Open
Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradictory results. Here, we examine…
View article: Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis1
Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis1 Open
We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts.…
View article: Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immun…
View article: Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity Open
View article: Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial Open
View article: Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis
Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis Open
Influenza-associated pulmonary aspergillosis (IAPA) has been reported increasingly since the advent of use of neuraminidase (NA) inhibitors following the 2009 influenza pandemic. We hypothesize that blocking host NA modulates the immune re…
View article: High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients
High dimensional profiling identifies specific immune types along the recovery trajectories of critically ill COVID19 patients Open
View article: Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages Open
View article: Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immun…
View article: Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019
Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019 Open
Objectives Emerging evidence of dysregulation of the myeloid cell compartment urges investigations on neutrophil characteristics in coronavirus disease 2019 (COVID‐19). We isolated neutrophils from the blood of COVID‐19 patients receiving …
View article: Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model Open
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immun…
View article: Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host
Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host Open
Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradictory results. Here, we examine…
View article: Mapping the recovery of critically ill COVID19 patients by high-dimensional profiling identifies longitudinal blood immunotypes
Mapping the recovery of critically ill COVID19 patients by high-dimensional profiling identifies longitudinal blood immunotypes Open
The COVID-19 pandemic poses a major burden on health-care and economic systems across the globe. Even though a majority of the population only develops minor symptoms upon SARS-CoV2 infection, a significant proportion are hospitalized at i…
View article: Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity Open
Epidemiological and clinical reports have indicated that the host immune response to SARS-CoV-2, more so than viral factors, determines COVID-19 disease severity. To elucidate the immunopathology underlying COVID-19 severity, cytokine and …