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View article: Venous Thromboembolism in Inherited Platelet Disorders: A Clinical Challenge
Venous Thromboembolism in Inherited Platelet Disorders: A Clinical Challenge Open
Inherited platelet disorders (IPDs) are rare hematological conditions characterized by abnormal platelet function or number, predisposing patients to bleeding. Even if they apparently lower the risk of venous thromboembolism (VTE), this is…
View article: The co-inheritance of two ITGB3 variants with additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia
The co-inheritance of two ITGB3 variants with additive detrimental effects on platelets leads to variant Glanzmann thrombasthenia Open
Not available.
View article: Developing an AI-Generated Peptide Targeting Platelet-type von Willebrand Disease
Developing an AI-Generated Peptide Targeting Platelet-type von Willebrand Disease Open
Platelet-type von Willebrand disease (PT-VWD) is a rare bleeding disorder caused by gain-of-function mutations in platelet glycoprotein Ib alpha (GPIbα). These mutations lead to a hyperactive protein-protein interaction (PPI) with von Will…
View article: Dicer Neosynthesis Regulates Platelet Reactivity: A Mechanism Altered in Type 2 Diabetes
Dicer Neosynthesis Regulates Platelet Reactivity: A Mechanism Altered in Type 2 Diabetes Open
BACKGROUND: Despite being anucleate, platelets contain mRNAs and synthesize new proteins. Platelets also contain microRNAs and Dicer (ribonuclease III enzyme Dicer-1), an enzyme required for microRNA maturation. The expression of Dicer and…
View article: Investigation of Bleeding Disorders: When and How Should We Test Platelet Functions?
Investigation of Bleeding Disorders: When and How Should We Test Platelet Functions? Open
Inherited platelet disorders (IPDs) are rare conditions with diverse underlying pathophysiology which should be suspected in patients presenting with mucocutaneous bleeding or hemorrhages upon hemostatic challenges, in the presence or not …
View article: Platelet transcriptomic changes in myocardial infarction are sex and clinical subtype-related: a step forward towards precision medicine?
Platelet transcriptomic changes in myocardial infarction are sex and clinical subtype-related: a step forward towards precision medicine? Open
View article: The 2024 Nobel prize in Medicine: impact on hemostasis and thrombosis research
The 2024 Nobel prize in Medicine: impact on hemostasis and thrombosis research Open
On October 7th, the Nobel Prize in Physiology or Medicine was awarded jointly to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation...
View article: Association of human leucocyte antigen loci with vaccine‐induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4‐derived peptides and <scp>MHC</scp>‐<scp>II</scp>
Association of human leucocyte antigen loci with vaccine‐induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4‐derived peptides and <span>MHC</span>‐<span>II</span> Open
Summary No risk factors have been identified for vaccine‐induced immune thrombotic thrombocytopenia (VITT) so far. The aim of this study was to identify human leucocyte antigen (HLA) alleles potentially associated with VITT susceptibility.…
View article: Prospective, international, multisite comparison of platelet isolation techniques for genome-wide transcriptomics: communication from the SSC of the ISTH
Prospective, international, multisite comparison of platelet isolation techniques for genome-wide transcriptomics: communication from the SSC of the ISTH Open
View article: Association of laboratory test results with the bleeding history in patients with inherited platelet function disorders (the Bleeding Assesment Tool - LABoratory tests substudy): communication from the Platelet Physiology ISTH-SSC
Association of laboratory test results with the bleeding history in patients with inherited platelet function disorders (the Bleeding Assesment Tool - LABoratory tests substudy): communication from the Platelet Physiology ISTH-SSC Open
View article: OC 39.1 Anti-integrin Immune Thrombocytopenia Autoantibodies Impair Megakaryocyte Migration, Polarization and Proplatelet Formation
OC 39.1 Anti-integrin Immune Thrombocytopenia Autoantibodies Impair Megakaryocyte Migration, Polarization and Proplatelet Formation Open
View article: Corrigendum to GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis [J Thromb Haemost. 2021 Oct;19(10):2612-2617]
Corrigendum to GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic, and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis [J Thromb Haemost. 2021 Oct;19(10):2612-2617] Open
View article: The amazing genetic complexity of anucleated platelets
The amazing genetic complexity of anucleated platelets Open
Not available
View article: A p.Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD
A p.Arg127Gln variant in GPIbα LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD Open
Gain-of-function (GOF) variants in GP1BA cause platelet-type von Willebrand disease (PT-VWD), a rare inherited autosomal dominant bleeding disorder characterized by enhanced platelet GPIbα to von Willebrand factor (VWF) interaction, and th…
View article: Expanding the genetic spectrum of <i>TUBB1</i>-related thrombocytopenia
Expanding the genetic spectrum of <i>TUBB1</i>-related thrombocytopenia Open
β1-Tubulin plays a major role in proplatelet formation and platelet shape maintenance, and pathogenic variants in TUBB1 lead to thrombocytopenia and platelet anisocytosis (TUBB1-RT). To date, the reported number of pedigrees with TUBB1-RT …
View article: Platelet dysfunction in platelet-type von Willebrand disease due to the constitutive triggering of the Lyn-PECAM1 inhibitory pathway
Platelet dysfunction in platelet-type von Willebrand disease due to the constitutive triggering of the Lyn-PECAM1 inhibitory pathway Open
Platelet-type von Willebrand disease (PT-VWD) is an inherited platelet disorder. It is characterized by macrothrombocytopenia and mucocutaneous bleeding, of variable severity, due to gain-of-function variants of GP1BA conferring to glycopr…
View article: Germline <i>GATA2</i> variant disrupting endothelial eNOS function and angiogenesis can be restored by c-Jun/AP-1 upregulation
Germline <i>GATA2</i> variant disrupting endothelial eNOS function and angiogenesis can be restored by c-Jun/AP-1 upregulation Open
GATA2 is a transcription factor with key roles in hematopoiesis. Germline GATA2 gene variants have been associated with several inherited and acquired hematologic disorders, including myelodysplastic syndromes. Among the spectrum of GATA2 …
View article: The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology
The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology Open
View article: Learning the Ropes of Platelet Count Regulation: Inherited Thrombocytopenias
Learning the Ropes of Platelet Count Regulation: Inherited Thrombocytopenias Open
Inherited thrombocytopenias (IT) are a group of hereditary disorders characterized by a reduced platelet count sometimes associated with abnormal platelet function, which can lead to bleeding but also to syndromic manifestations and predis…
View article: Association of Neutrophil Activation, More Than Platelet Activation, With Thrombotic Complications in Coronavirus Disease 2019
Association of Neutrophil Activation, More Than Platelet Activation, With Thrombotic Complications in Coronavirus Disease 2019 Open
Background Severe acute respiratory syndrome coronavirus 2 infection is associated with hypercoagulability, which predisposes to venous thromboembolism (VTE). We analyzed platelet and neutrophil activation in patients with coronavirus dise…
View article: Role of endothelial dysfunction in the thrombotic complications of COVID-19 patients
Role of endothelial dysfunction in the thrombotic complications of COVID-19 patients Open
View article: Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome
Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome Open
Gray platelet syndrome (GPS) is a rare recessive disorder caused by biallelic variants in NBEAL2 and characterized by bleeding symptoms, the absence of platelet α-granules, splenomegaly, and bone marrow (BM) fibrosis. Due to the rarity of …
View article: Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome
Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome Open
Gray platelet syndrome (GPS) is a rare recessive disorder caused by variants in NBEAL2 and characterized by bleeding symptoms, the absence of platelet ɑ-granules, splenomegaly and bone marrow (BM) fibrosis. Due to its rarity, it has been d…
View article: Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: A communication from the Platelet Physiology SSC
Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: A communication from the Platelet Physiology SSC Open
View article: ISSUE INFORMATION
ISSUE INFORMATION Open
View article: Antithrombotic prophylaxis for surgery-associated venous thromboembolism risk in patients with inherited platelet disorders. The SPATA-DVT Study
Antithrombotic prophylaxis for surgery-associated venous thromboembolism risk in patients with inherited platelet disorders. The SPATA-DVT Study Open
Major surgery is associated with an increased risk of venous thromboembolism (VTE), thus the application of mechanical or pharmacologic prophylaxis is recommended. The incidence of VTE in patients with inherited platelet disorders (IPD) un…
View article: ISSUE INFORMATION
ISSUE INFORMATION Open
Research and Prac ce in Thrombosis andHaemostasis (RPTH) is the newest journal of the Interna onal Society on Thrombosis and Haemostasis (ISTH) and the newest journal in the fi eld of thrombosis and hemostasis.Complemen ng
View article: Curated disease‐causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH
Curated disease‐causing genes for bleeding, thrombotic, and platelet disorders: Communication from the SSC of the ISTH Open
View article: Maraviroc Intensification Modulates Atherosclerotic Progression in HIV-Suppressed Patients at High Cardiovascular Risk. A Randomized, Crossover Pilot Study
Maraviroc Intensification Modulates Atherosclerotic Progression in HIV-Suppressed Patients at High Cardiovascular Risk. A Randomized, Crossover Pilot Study Open
Maraviroc led to significant improvements in several markers for cardiovascular risk, endothelial dysfunction, arterial stiffness, and early carotid atherosclerosis, which was accompanied by an increase of vascular competence, without seem…
View article: Mechanisms of thrombocytopenia in platelet-type von Willebrand disease
Mechanisms of thrombocytopenia in platelet-type von Willebrand disease Open
Platelet-type von Willebrand disease is an inherited platelet disorder characterized by thrombocytopenia with large platelets caused by gain-of-function variants in GP1BA leading to enhanced GPIbα-von Willebrand factor (vWF) interaction. G…