Lorena Arranz
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Bone marrow sympathetic neuropathy is a hallmark of hematopoietic malignancies and it involves severe ultrastructural damage Open
The hematopoietic stem cell (HSC) niche in the bone marrow (BM) supports HSC function, fate and numbers [1]. Sympathetic fibres innervate the BM and are components of the hematopoietic stem and progenitor cell (HSPC) niche [2]. Neuropathy …
View article: Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells Open
Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheles…
View article: Author response: Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
Author response: Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Acute myeloid leukaemi…
The Hematology of Tomorrow Is Here—Preclinical Models Are Not: Cell Therapy for Hematological Malignancies Open
The purpose of this review is to present the current knowledge on the clinical use of several forms of cell therapy in hematological malignancies and the preclinical models available for their study. In the context of allogeneic hematopoie…
Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities Open
Oxidized, damaged and misfolded proteins accumulate during aging and contribute to impaired cell function and tissue homeodynamics. Damaged proteins are degraded by cellular clearance mechanisms like the 20S proteasome. Aging relates to lo…
View article: Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells Open
Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheles…
View article: Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia
Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is a heterogeneous, complex, and deadly disease, whose treatment has hardly evolved for decades and grounds on the use of intensive chemotherapy regimens. Chemotherapy helps reduce AML bulk, but promotes relaps…
Bone Marrow Adipocytes: The Enigmatic Components of the Hematopoietic Stem Cell Niche Open
Bone marrow adipocytes (BMA) exert pleiotropic roles beyond mere lipid storage and filling of bone marrow (BM) empty spaces, and we are only now beginning to understand their regulatory traits and versatility. BMA arise from the differenti…
View article: Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms
Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms Open
Background: BM HSC accumulate during aging but are functionally impaired; however, it remains debated whether this aging results from HSC-intrinsic and/or -extrinsic mechanisms. Myeloid malignancies are more frequent in the elderly, but wh…
View article: Updates on Old and Weary Haematopoiesis
Updates on Old and Weary Haematopoiesis Open
Blood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow create a specific n…
Multiple faces of succinate beyond metabolism in blood Open
Succinate is an essential intermediate of the tricarboxylic acid cycle that exerts pleiotropic roles beyond metabolism in both physiological and pathological conditions. Recent evidence obtained in mouse models shows its essential role reg…
Nestin-expressing progenitor cells: function, identity and therapeutic implications Open
The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cel…
IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene Open
Recently we described that endonuclease inactive DNase I translocated into the nucleus in response to increased endogenous IL-1β expression. Here, we demonstrate impact and function of translocated DNase I in tubular cells. Effect of cytok…
Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications Open
Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both physiological and pathological conditions. It is produced by different cell subsets, and drives a wide range of inflammatory responses in numerous target c…
Retraction Note: Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease Open
Recent evidence shows increased and decreased expression of Ezh2 in cancer, suggesting a dual role as an oncogene or tumour suppressor. To investigate the mechanism by which Ezh2-mediated H3K27 methylation leads to cancer, we generated con…