Libertad Alzamora‐Gonzales
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Synergistic Anticancer Activity of Fucoidan from Lessonia trabeculata Combined with Chemotherapeutic Agents in 4T1 Breast Spheroids Open
Triple-negative breast cancer (TNBC) is known for being aggressive and potentially resistant to chemotherapy. This means that new ways to improve cancer treatments are a priority. So, the anticancer effect of binary combinations of fucoida…
Determining the Impact of Exogenous Factors in Acute Respiratory Infections Using a Mathematical Epidemiological Model—Case Study of COVID-19 in a Peruvian Hospital Open
In this study, we develop and analyze an extended SEIR-type compartmental model that incorporates vaccination and treatment to describe the dynamics of acute respiratory infection transmission. The model subdivides the infectious populatio…
PROFILE OF BACTERIAL PATHOGENS IN SURGICAL SITE INFECTIONS AND THEIR ANTIBIOGRAM IN A TERTIARY CARE HOSPITAL IN SOUTHERN INDIA. Open
Background: Surgical site infection (SSI) is a common complication following surgery, contributing significantly to post operative morbidity and mortality. This study aims to identify the microorganisms responsible for SSIs and assess th…
CD4+/CD8+ lymphocyte ratio as a biomarker of morbidity and severity in patients with moderate and severe COVID-19 Open
The assessment of lymphocyte populations allows the monitoring, follow-up and treatment of patients with various infectious diseases. Acute respiratory syndrome caused by coronavirus (SARS-CoV-2), can lead to a decrease in circulating lymp…
Formulation and Evaluation of Metformin Controlled Release Tablets Using Tamarind Seed Gum Powder as a Natural Polymer Open
Aim: This research aims to develop controlled-release tablets of metformin using tamarind seed gum powder as the matrix-forming agent. Methods: Tamarind seeds were thoroughly cleaned, boiled and dehulled manually to remove the seed coat. T…
Fucoidan from Lessonia trabeculata Induces Apoptosis through Caspase Dependent and Caspase-Independent Activation in 4T1 Breast Adenocarcinoma In Vitro Open
Experiments conducted on triple-negative breast cancer have shown that fucoidan from Lessonia trabeculata (FLt) exhibits cytotoxic and antitumor properties. However, further research is necessary to gain a complete understanding of its bio…
Expresión transcripcional de receptores tipo Toll y citoquinas proinflamatorias en macrófagos infectados con <i>Leishmania braziliensis</i> nativa Open
Introduction. The Toll-like receptor (TLR) interacting with the promastigote of Leishmania spp. determines the cellular activation pathway. Objective. To determine the transcriptional expression of TLR-3, TLR-4, TLR-9, IL-12 and TNF-α in m…
Lupinus mutabilis Sweet (Tarwi) γ-conglutin Modulates TNF-α and IL-1α Transcriptional Expression in Human Monocytes Infected with Leishmania (V.) peruviana Open
Background: γ-Conglutin is a hemagglutinating lectin found in the seeds of the Andean legume Lupinus mutabilis. Leishmania (Viannia) peruviana is the etiological agent of cutaneous leishmaniasis, which is endemic in Peru. Leishmaniasis is …
Antitumor and immunomodulatory activity of fucoidan from the brown alga Lessonia trabeculata (Lessoniaceae) on breast cancer spheroids Open
Introduction: The therapeutic benefits of the brown algae fucoidan in the treatment of breast cancer have attracted considerable interest in recent years. However, research using spheroids which provide relevant results in trials for antit…
A Method to Evaluate the Ultrastructure of Free Cells by Scanning Electron Microscopy Open
The aim of this study was to develop an easy method for the analysis of the surface ultrastructure in prokaryotic and eukaryotic free cells. The procedure to prepare three types of free cells, the adhesion to poly-L-lysin (PLL)-coated glas…
Efecto del estímulo masticatorio y estrés agudo sobre la interleuquina 6, la memoria y el aprendizaje espacial en ratones Balb/c Open
Introduction. Acute stress alters memory and spatial learning and the expression of interleukin 6, the chewing stimulus would prevent these effects. Objective. To determine the effect of chewing stimulation and acute stress on the expressi…
Isolation of a Hemagglutinating γ-conglutin from Seeds of the Andean Legume Lupinus mutabilis Sweet (Tarwi) Open
Background: Lupinus mutabilis Sweet is a species of Andean legume with a high content of proteins, which present hemagglutinating lectins. Here, we demonstrated that the γ-conglutin lectin isolated from L. mutabilis seeds is responsible fo…
Rapid method for counting of blood leukocytes and its usefulness in health status assessment of rainbow trout (Oncorhynchus mykiss) Open
The analysis of the ratio and number of blood cells is a very reliable way to assess the health status in humans and other species. The aim was to standardize a methodology for rapid quantification of blood leukocytes in rainbow trout Onco…