Explanipedia

Urban Air Pollution Exposure Impairs Memory and Social Behavior and Reduces the Repressive Epigenetic Marks H3k9me2/3 in the Mouse Hippocampus and Olfactory Bulb Open

Nur Jury, Mario Sánchez-Rubio, Gino Nardocci, Constanza Mercado, Nicolas Peña-Baeza , et al. · 2025

Impact of KDM6B mosaic brain knockout on synaptic function and behavior Open

Bastián Brauer, Carlos Ancatén-González, Constanza Ahumada-Marchant, Rodrigo Meza, Nicolás Merino-Véliz , et al. · 2024

RSPO/LGR signaling mediates astrocyte-induced proliferation of adult hippocampal neural stem cells Open

Daniela Valenzuela-Bezanilla, Muriel D. Mardones, M. Galassi, Sebastián B. Arredondo, Sebastian H Santibanez , et al. · 2023

In the dentate gyrus of the adult hippocampus, neurogenesis from neural stem cells (NSCs) is regulated by Wnt signals from the local microenvironment. The Wnt/β-catenin pathway is active in NSCs, where it regulates proliferation and fate c…

Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons Open

Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán , et al. · 2023

Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal d…

Wnt Signaling in the Adult Hippocampal Neurogenic Niche Open

Sebastián B. Arredondo, Daniela Valenzuela-Bezanilla, Sebastian H Santibanez, Lorena Varela‐Nallar · 2022

The subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) is a neurogenic niche of the adult brain that contains neural stem cells (NSCs) able to generate excitatory glutamatergic granule neurons, which integrate into the DG circuit…

H3K9 Methyltransferases Suv39h1 and Suv39h2 Control the Differentiation of Neural Progenitor Cells in the Adult Hippocampus Open

Miguel V. Guerra, Matías I. Cáceres, Andrea Herrera-Soto, Sebastián B. Arredondo, Manuel Varas‐Godoy , et al. · 2022

In the dentate gyrus of the adult hippocampus new neurons are generated from neural precursor cells through different stages including proliferation and differentiation of neural progenitor cells and maturation of newborn neurons. These st…

Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease Open

Sebastián B. Arredondo, Daniel T. Reyes, Andrea Herrera-Soto, Muriel D. Mardones, Nibaldo C. Inestrosa , et al. · 2021

In Alzheimer´s disease (AD) there is a reduction in hippocampal neurogenesis that has been associated to cognitive deficits. Previously we showed that Andrographolide (ANDRO), the main bioactive component of Andrographis paniculate , induc…

Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase Open

Eva Ramos‐Fernández, Macarena S. Arrázola, Carolina A. Oliva, Sebastián B. Arredondo, Lorena Varela‐Nallar , et al. · 2021

Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG Open

Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco J. Carvajal, Fernanda G. Guerrero , et al. · 2020

Background Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediat…

Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease Open

Sebastián B. Arredondo, Daniela Valenzuela-Bezanilla, Muriel D. Mardones, Lorena Varela‐Nallar · 2020

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals provided by the local hippocampal microenvironment support neural stem cell proliferation, differentiation, and maturation of newborn neurons into func…

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice Open

Nur Jury, Sebastián Abarzúa, Iván Darío Parrado Díaz, Miguel V. Guerra, Estíbaliz Ampuero , et al. · 2020

Background Hexanucleotide repeat expansions of the G 4 C 2 motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues from C9ALS/FTD …

Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution Open

Lilian Calderón‐Garcidueñas, Andrea Herrera-Soto, Nur Jury, Barbara A. Maher, Angélica González-Maciel , et al. · 2020

Additional file 2 of Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG Open

Sofía Espinoza, Sebastián B. Arredondo, Francisca Barake, Francisco J. Carvajal, Fernanda G. Guerrero , et al. · 2020

Additional file 2. Excel sheet containing source data file for Fig. 1e, 2c, d, 5a, b, 6a, c, d and Additional file 1: Fig. S4.

Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice Open

Fernando J. Bustos, Estíbaliz Ampuero, Nur Jury, Rodrigo Aguilar, Fahimeh Falahi , et al. · 2017

The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished in ageing and neurodegenerative disorders, including…

NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB‐P, and H3K27ac Open

Fernando J. Bustos, Nur Jury, Pablo Martínez, Estíbaliz Ampuero, Matías Campos , et al. · 2017

Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons and promote plasticit…

Frizzled-1 receptor regulates adult hippocampal neurogenesis Open

Muriel D. Mardones, Gabriela A. Andaur, Manuel Varas‐Godoy, J. Henriquez, Felipe Salech , et al. · 2016

<span>CD</span>73‐mediated adenosine production promotes stem cell‐like properties in mouse Tc17 cells Open

Felipe Flores‐Santibáñez, Dominique Fernández, Daniel Meza, Gabriela Tejón, Leonardo Vargas , et al. · 2015

Summary The CD 73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up‐regulated in T helper type 17 cells when generated in the pre…

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance Open

Pedro Cisternas, Paulina Salazar, Felipe Serrano, Carla Montecinos-Oliva, Sebastián B. Arredondo , et al. · 2015

The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons Open

Iván E. Alfaro, Lorena Varela‐Nallar, Manuel Varas‐Godoy, Nibaldo C. Inestrosa · 2015

Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of <span>A</span>lzheimer's Disease Open

Cheril Tapia‐Rojas, Florencia C. Aránguiz, Lorena Varela‐Nallar, Nibaldo C. Inestrosa · 2015

A lzheimer's disease ( AD ) is a neurodegenerative disorder characterized by loss of memory and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid‐β peptide ( A β) and neurofibrillary tangles formed of tau p…

Andrographolide Stimulates Neurogenesis in the Adult Hippocampus Open

Lorena Varela‐Nallar, Sebastián B. Arredondo, Cheril Tapia‐Rojas, Juan L. Hancke, Nibaldo C. Inestrosa · 2015

Andrographolide (ANDRO) is a labdane diterpenoid component of Andrographis paniculata widely used for its anti-inflammatory properties. We have recently determined that ANDRO is a competitive inhibitor of glycogen synthase kinase-3 β (GSK-…

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