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View article: Reimagining Primary Health Care: A Historical and Contemporary Review of Community-Based Care Models and Innovations
Reimagining Primary Health Care: A Historical and Contemporary Review of Community-Based Care Models and Innovations Open
BACKGROUND Historically, community-based care has served as a foundation of health service delivery in resource-constrained settings. However, shifting demographics, rising chronic diseases burdens, and digital transformations increasingly…
View article: Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated <i>Plasmodium falciparum</i> malaria
Population pharmacokinetics of artemether–lumefantrine plus amodiaquine in patients with uncomplicated <i>Plasmodium falciparum</i> malaria Open
Aims Resistance to the artemisinins and the artemisinin‐based combination therapy (ACT) partner drugs has developed in Southeast Asia, and artemisinin resistance has also emerged in eastern Africa. Triple ACTs (triple artemisinin‐based com…
View article: Translating investments into results: the role of the World Bank in global health
Translating investments into results: the role of the World Bank in global health Open
View article: Perceptions of shorter radical cure Plasmodium vivax treatment regimens and their implementation: a qualitative study among stakeholders in Cambodia
Perceptions of shorter radical cure Plasmodium vivax treatment regimens and their implementation: a qualitative study among stakeholders in Cambodia Open
View article: Effectiveness of CoronaVac primary series with and without booster against hospitalized COVID-19 during the Omicron-predominant epidemic wave in the Philippines: a test-negative case–control study
Effectiveness of CoronaVac primary series with and without booster against hospitalized COVID-19 during the Omicron-predominant epidemic wave in the Philippines: a test-negative case–control study Open
Two doses of CoronaVac offered moderate protection against severe COVID-19. Heterologous boosters significantly improved protection, especially against critical illness and death, supporting ongoing booster campaigns after inactivated vacc…
View article: Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations
Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations Open
Cluster randomised trials (CRTs) are important tools for evaluating the community-wide effect of malaria interventions. During the design stage, CRT sample sizes need to be inflated to account for the cluster heterogeneity in measured outc…
View article: Community perceptions and acceptance of ivermectin for malaria control on Sumba Island, Indonesia
Community perceptions and acceptance of ivermectin for malaria control on Sumba Island, Indonesia Open
Background Indonesia has made significant progress in malaria control, however hotspots such as Sumba Island continue to experience high rates of malaria transmission, driven by multiple Anopheles mosquito species. The Sumba Livestock Iver…
View article: Co-design of a routine clinical review to improve the safety of high dose radical cure treatment for Plasmodium vivax malaria: findings from Cambodia and Ethiopia
Co-design of a routine clinical review to improve the safety of high dose radical cure treatment for Plasmodium vivax malaria: findings from Cambodia and Ethiopia Open
Identifying how clinical review visits could be adapted to local settings is important and can be achieved through co-creation. Collaboration has the potential to enable quality of care and patient safety. Suitable ways of reinforcing this…
View article: Efficacy, immunogenicity, and safety of heterologous boosting with a novel chimera Chinese mRNA (RQ3013) SARS-CoV-2 vaccine: A randomized, double-blind, active-controlled trial
Efficacy, immunogenicity, and safety of heterologous boosting with a novel chimera Chinese mRNA (RQ3013) SARS-CoV-2 vaccine: A randomized, double-blind, active-controlled trial Open
A randomized, double-blind, controlled phase 3 trial was conducted during a COVID-19 outbreak after the initial, stringent zero-Covid policy was relaxed in three provinces. Eligible adults aged ≥18 years who had received three doses of ina…
View article: Operational evaluation of the deployment of Malaria/CRP Duo and Dengue Duo rapid diagnostic tests for the management of febrile illness by village malaria workers in rural Cambodia
Operational evaluation of the deployment of Malaria/CRP Duo and Dengue Duo rapid diagnostic tests for the management of febrile illness by village malaria workers in rural Cambodia Open
Introduction The decline in malaria cases in Cambodia has led to a relative increase in non-malarial febrile illness. In rural Cambodia, village malaria workers (VMWs) provide early diagnosis and treatment for malaria, but their role and r…
View article: Effect of a novel house design (star home) on indoor malaria mosquito abundance in rural Tanzania: secondary outcomes of an open-label, household, randomised controlled trial
Effect of a novel house design (star home) on indoor malaria mosquito abundance in rural Tanzania: secondary outcomes of an open-label, household, randomised controlled trial Open
Hanako Foundation, Singapore.
View article: Parasitaemia and fever in uncomplicated Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis
Parasitaemia and fever in uncomplicated Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis Open
Background Parasite density thresholds used for diagnosing symptomatic malaria are defined by the relationship between parasitaemia and fever. This relationship can inform the design and development of novel diagnostic tests but appropriat…
View article: Effect of a novel house (Star home) and toilet design on domestic fly densities in rural Tanzania
Effect of a novel house (Star home) and toilet design on domestic fly densities in rural Tanzania Open
Background Diarrhoeal disease is the third leading cause of death in children under 5 years old with domestic flies acting as important mechanical vectors of diarrhoeal pathogens. To assess the effectiveness of a novel house design, “Star …
View article: Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations
Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations Open
Cluster randomised trials (CRTs) are important tools for evaluating the community-wide effect of malaria interventions. During the design stage, CRT sample sizes need to be inflated to account for the cluster-heterogeneity in measured outc…
View article: Author Correction: Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia
Author Correction: Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia Open
View article: Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania
Community responses to a novel house design: A qualitative study of “Star Homes” in Mtwara, southeastern Tanzania Open
Introduction To evaluate the impact of a novel design “Star Home” on the incidence of malaria, respiratory tract infections and diarrheal diseases among children, randomly selected households in Mtwara, Tanzania were offered a free, new St…
View article: Roll out and prospects of the malaria vaccine R21/Matrix-M
Roll out and prospects of the malaria vaccine R21/Matrix-M Open
In this Perspective article, Lorenz von Seidlein outlines the promise of two malaria vaccines, and discusses some of the considerations for their roll out.
View article: Acceptability of improved cook stoves-a scoping review of the literature
Acceptability of improved cook stoves-a scoping review of the literature Open
Improved cooking stoves (ICS) are intended to reduce indoor air pollution and the inefficient use of fuel yet there is often reticence to shift permanently to ICS. Drawing on a scoping review, this article aims to provide a comprehensive o…
View article: Effectiveness and Safety of High Dose Primaquine and Tafenoquine in Plasmodium vivax Patients (EFFORT) - A Multi-Centre, Open Label, Superiority Randomised Controlled Trial
Effectiveness and Safety of High Dose Primaquine and Tafenoquine in Plasmodium vivax Patients (EFFORT) - A Multi-Centre, Open Label, Superiority Randomised Controlled Trial Open
View article: Effectiveness of Coronavac Primary Series with and Without Booster Against Hospitalized COVID-19 During the Omicron-Predominant Epidemic Wave in the Philippines: A Test-Negative Case-Control Study
Effectiveness of Coronavac Primary Series with and Without Booster Against Hospitalized COVID-19 During the Omicron-Predominant Epidemic Wave in the Philippines: A Test-Negative Case-Control Study Open
View article: How do study participants want to be informed about study results: Findings from a malaria trial in Cambodia, Ethiopia, Pakistan, and Indonesia
How do study participants want to be informed about study results: Findings from a malaria trial in Cambodia, Ethiopia, Pakistan, and Indonesia Open
Background: Researchers acknowledge the need to share study results with the patients and their communities, but this is not done consistently due to a plethora of barriers, including a paucity of data to guide best practice approaches in …
View article: Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders
Malaria elimination challenges in countries approaching the last mile: a discussion among regional stakeholders Open
In countries approaching malaria elimination, resourcing community-based health workers could play a critical role in enhancing malaria surveillance, early case detection and treatment, including interventions targeting migrant populations…
View article: Systematic review and individual patient data meta-analysis on glucose- 6 – phosphate dehydrogenase activities measured by a semi-quantitative handheld Biosensor
Systematic review and individual patient data meta-analysis on glucose- 6 – phosphate dehydrogenase activities measured by a semi-quantitative handheld Biosensor Open
Measurement of glucose-6-phosphate dehydrogenase (G6PD) activity guides hypnozoitocidal treatment of P. vivax malaria. The G6PD Standard (SDBiosensor, Republic of Korea) here referred to as “Biosensor” is a quantitative point-of-care diagn…
View article: Regional action needed to halt antimalarial drug resistance in Africa
Regional action needed to halt antimalarial drug resistance in Africa Open
View article: Correction: Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages
Correction: Expanding the role of village malaria workers in Cambodia: Implementation and evaluation of four health education packages Open
[This corrects the article DOI: 10.1371/journal.pone.0283405.].
View article: Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background
Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background Open
View article: Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia
Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia Open
View article: Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia
Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia Open
The mosquito-lethal effect of commercially available standard and long-lasting ivermectin formulations were evaluated in cattle and buffalo against wild-caught Anopheles on Sumba Island, Indonesia. Cattle have substantially higher blood-le…
View article: Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial
Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial Open
Background Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention random…
View article: Implementation of Glucose-6-Phosphate Dehydrogenase (G6PD) testing for Plasmodium vivax case management, a mixed method study from Cambodia
Implementation of Glucose-6-Phosphate Dehydrogenase (G6PD) testing for Plasmodium vivax case management, a mixed method study from Cambodia Open
Plasmodium vivax remains a challenge for malaria elimination since it forms dormant liver stages (hypnozoites) that can reactivate after initial infection. 8-aminoquinolone drugs kill hypnozoites but can cause severe hemolysis in individua…