Lorenzo Antonelli
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View article: An analytical methodology for the quantitative profiling of fat-soluble antioxidants in maternal blood, umbilical cord blood and meconium
An analytical methodology for the quantitative profiling of fat-soluble antioxidants in maternal blood, umbilical cord blood and meconium Open
The determination of fat-soluble antioxidants represents a significant analytical challenge, particularly when dealing with biological matrices available only in limited quantities, such as those collected from preterm infants. This paper …
View article: Smart and sustainable 3D-printed electrochemical device for diclofenac remediation and monitoring in water
Smart and sustainable 3D-printed electrochemical device for diclofenac remediation and monitoring in water Open
In recent years, emerging contaminants in water, such as pesticides and pharmaceuticals, have gained significant attention, underscoring the need for innovative purification and monitoring solutions. Diclofenac, a widely used nonsteroidal …
View article: Electrochemical (bio)sensors for cancer therapy monitoring
Electrochemical (bio)sensors for cancer therapy monitoring Open
View article: Sorption of cortisone on polypropylene, polystyrene, and polyethylene microplastics
Sorption of cortisone on polypropylene, polystyrene, and polyethylene microplastics Open
View article: Composite microbeads of cellulose acetate upcycled from waste for water remediation
Composite microbeads of cellulose acetate upcycled from waste for water remediation Open
View article: Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis
Expanding the molecular landscape of fragments binding to trypanothione reductase, a legitimate target for drug design against human African trypanosomiasis Open
Crystallographic fragment screening is a powerful methodology that enables the identification of low molecular weight ligands and has shown great promises in drug discovery. In this work we report the results of a fragment screening carrie…
View article: The complex world of eutectic solvents: Guidelines for a correct characterization and use in sample preparation
The complex world of eutectic solvents: Guidelines for a correct characterization and use in sample preparation Open
Mixtures with low-temperature phase transitions have been known since the late 19th century, when the term “eutaxia” was first introduced. A major turning point came in 2003, when Abbott and colleagues coined the term “deep eutectic solven…
View article: Exploring the extraction capabilities of natural cyclodextrin-nanosponges: The improvement moving from α- to γ-cyclodextrin-based polymers
Exploring the extraction capabilities of natural cyclodextrin-nanosponges: The improvement moving from α- to γ-cyclodextrin-based polymers Open
Cyclodextrins (CD) are cyclic oligosaccharides known for their capability to form inclusion complexes with molecules of appropriate size. CDs can also be used as polyfunctional monomers in polymerization reactions to prepare specialised so…
View article: One-step extraction for a high throughput multiresidue analysis of chiral and achiral pesticides in milk
One-step extraction for a high throughput multiresidue analysis of chiral and achiral pesticides in milk Open
View article: Upcycling Waste: Designing Cellulose Acetate Microbeads for Advanced Water Remediation
Upcycling Waste: Designing Cellulose Acetate Microbeads for Advanced Water Remediation Open
View article: One-Step Extraction for High Throughput Multiresidue Analyses of Chiral and Achiral Pesticides in Milk
One-Step Extraction for High Throughput Multiresidue Analyses of Chiral and Achiral Pesticides in Milk Open
View article: ESI MS Studies of <i>T. Brucei</i> Trypanothione Reductase and its Reactions With Selected Metal Compounds
ESI MS Studies of <i>T. Brucei</i> Trypanothione Reductase and its Reactions With Selected Metal Compounds Open
Trypanothione reductase from Trypanosoma brucei ( Tb TR) is a key enzyme of the parasite responsible for human African trypanosomiasis. Tb TR catalyzes the reduction of trypanothione, an antioxidant dithiol that protects trypanosomatid par…
View article: The <i>Z</i> isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin <scp>B</scp> <sub>6</sub> salvage pathway and a potential chemotherapeutic target
The <i>Z</i> isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin <span>B</span> <sub>6</sub> salvage pathway and a potential chemotherapeutic target Open
Pyridoxal 5′‐phosphate (PLP), the catalytically active form of vitamin B 6 , acts as a cofactor in many metabolic processes. In humans, PLP is produced in the reactions catalysed by pyridox(am)ine 5′‐phosphate oxidase (PNPO) and pyridoxal …
View article: Current trends to green food sample preparation. A review
Current trends to green food sample preparation. A review Open
Food analysis plays an important role in preserving the integrity and quality of food. Despite these noble goals, most official methods for the analysis of nutrients (vitamins, carotenoids, etc.) antioxidants (polyphenols, etc.), and conta…
View article: Sorcin in Cancer Development and Chemotherapeutic Drug Resistance
Sorcin in Cancer Development and Chemotherapeutic Drug Resistance Open
SOluble Resistance-related Calcium-binding proteIN (sorcin) earned its name due to its co-amplification with ABCB1 in multidrug-resistant cells. Initially thought to be an accidental consequence of this co-amplification, recent research in…
View article: Recovery of cellulose acetate bioplastic from cigarette butts: realization of a sustainable sorbent for water remediation
Recovery of cellulose acetate bioplastic from cigarette butts: realization of a sustainable sorbent for water remediation Open
View article: Nanocomposite microbeads made of recycled polylactic acid for the magnetic solid phase extraction of xenobiotics from human urine
Nanocomposite microbeads made of recycled polylactic acid for the magnetic solid phase extraction of xenobiotics from human urine Open
View article: Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase Open
Adequate levels of pyridoxal 5′‐phosphate (PLP), the catalytically active form of vitamin B 6 , and its proper distribution in the body are essential for human health. The PLP recycling pathway plays a crucial role in these processes and i…
View article: Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis
Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis Open
Trypanothione reductase (TR) is a suitable target for drug discovery approaches against leishmaniasis, although the identification of potent inhibitors is still challenging. Herein, we harnessed a fragment-based drug discovery (FBDD) strat…
View article: Solid-phase extraction combined with dispersive liquid-liquid microextraction for the analysis of glucocorticoids in environmental waters using liquid chromatography-tandem mass spectrometry
Solid-phase extraction combined with dispersive liquid-liquid microextraction for the analysis of glucocorticoids in environmental waters using liquid chromatography-tandem mass spectrometry Open
This paper illustrates an enrichment procedure based on the combination of solid phase extraction (SPE) with dispersive liquid-liquid microextraction (DLLME) for the determination of ng/L concentration levels of glucocorticoids in river wa…
View article: An enantioselective high-performance liquid chromatography-mass spectrometry method to study the fate of quizalofop-P-ethyl in soil and selected agricultural products
An enantioselective high-performance liquid chromatography-mass spectrometry method to study the fate of quizalofop-P-ethyl in soil and selected agricultural products Open
View article: Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands
Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands Open
The σ1 receptor (σ1-R) is an enigmatic endoplasmic reticulum resident transmembrane protein implicated in a variety of central nervous system disorders and whose agonists have neuroprotective activity. In spite of σ1-R’s physio-pathologica…
View article: Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site
Inhibition of Leishmania infantum Trypanothione Reductase by New Aminopropanone Derivatives Interacting with the NADPH Binding Site Open
Background: As a result of the paucity of treatment, Leishmaniasis continues to provoke about 60,000 deaths every year worldwide. New molecules are needed, and drug discovery research is oriented toward targeting proteins crucial for paras…
View article: Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation
Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation Open
Synthetic therapeutic peptides (STP) are intensively studied as new‐generation drugs, characterized by high purity, biocompatibility, selectivity and stereochemical control. However, most of the studies are focussed on the bioactivity of S…
View article: The Training needs of the Manager of Allied Health Professions
The Training needs of the Manager of Allied Health Professions Open
Background: Since its establishment under Italian law 251/2000, the role of the head of health professions has felt the need to develop and expand managerial skills. Despite the existence of training courses for general managers of health …