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View article: Methodology for the Development of the Allergic Rhinitis and Its Impact on Asthma ( <scp>ARIA</scp> )‐EAACI 2024–2025 Guidelines: From Evidence‐to‐Decision Frameworks to Digitalised Shared Decision‐Making Algorithms
Methodology for the Development of the Allergic Rhinitis and Its Impact on Asthma ( <span>ARIA</span> )‐EAACI 2024–2025 Guidelines: From Evidence‐to‐Decision Frameworks to Digitalised Shared Decision‐Making Algorithms Open
The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines produced their first edition in 1999, with subsequent revisions in 2008, 2010, 2016 and 2019. A new iteration of ARIA—ARIA 2024–2025—in collaboration with EAACI is currently …
View article: Molecular allergens drive risk stratification and immunotherapy in Hymenoptera venom allergy
Molecular allergens drive risk stratification and immunotherapy in Hymenoptera venom allergy Open
View article: Analysis of trends in single inhaler triple therapy (SITT) use and clinical characteristics of patients with severe asthma: data from the IRSA registry
Analysis of trends in single inhaler triple therapy (SITT) use and clinical characteristics of patients with severe asthma: data from the IRSA registry Open
Background. Triple therapy with inhaled corticosteroids (ICS), long-acting β₂-agonists (LABA), and long-acting muscarinic antagonists (LAMA) is recommended for severe asthma patients with uncontrolled symptoms. Single-inhaler triple therap…
View article: Is Shampooing Enough to Certify Hospital Dogs? Considering the Role of Owners and Trainers
Is Shampooing Enough to Certify Hospital Dogs? Considering the Role of Owners and Trainers Open
View article: Pollen-induced asthma: a specific pheno-endotype of disease?
Pollen-induced asthma: a specific pheno-endotype of disease? Open
Asthma is a heterogeneous syndrome with a significant social and economic impact. While the knowledge of pheno-endotypes has advanced in severe asthma, little attention has been paid to the phenotypes of mild-moderate asthma. Along this li…
View article: ARIA-Italy multidisciplinary consensus on nasal polyposis and biological treatments: Update 2025
ARIA-Italy multidisciplinary consensus on nasal polyposis and biological treatments: Update 2025 Open
In recent years, it was recognized that type-2 inflammation connects nasal polyposis and severe asthma (SA) in addition to other type-2 diseases. Thus, some biological drugs developed for SA appeared to exert a favourable effect also in na…
View article: Skin prick test wheal size: a potential predictor of respiratory allergies?
Skin prick test wheal size: a potential predictor of respiratory allergies? Open
Dear Editor,The skin prick test is the most commonly used method for diagnosing IgE-mediated sensitizations in conditions like bronchial asthma, allergic rhinitis, and food allergies... ******************************** Promoted by the Ital…
View article: <scp>EAACI</scp> Guidelines on Environmental Science for Allergy and Asthma—Recommendations on the Impact of Indoor Air Pollutants on the Risk of New‐Onset Asthma and on Asthma‐Related Outcomes
<span>EAACI</span> Guidelines on Environmental Science for Allergy and Asthma—Recommendations on the Impact of Indoor Air Pollutants on the Risk of New‐Onset Asthma and on Asthma‐Related Outcomes Open
The EAACI Guidelines used the GRADE approach to evaluate the impact of major indoor air pollutants (dampness and mould, cleaning agents, volatile organic compounds and pesticides) on the risk of new‐onset asthma and on asthma‐related outco…
View article: Expert opinion on gray areas in asthma management: A lesson from the innovative project “revolution in asthma” of the Italian thoracic society (AIPO‐ITS)
Expert opinion on gray areas in asthma management: A lesson from the innovative project “revolution in asthma” of the Italian thoracic society (AIPO‐ITS) Open
Background Despite the availability of numerous guidelines for asthma management, their recommendations are not consistently implemented in clinical practice. This discrepancy between guidelines and real‐world practice among Italian health…
View article: A narrative review on allergy and exposure to domestic and non-domestic animals: favorable and unfavorable effects
A narrative review on allergy and exposure to domestic and non-domestic animals: favorable and unfavorable effects Open
The aim of this contribution was to highlight the "favorable" and "unfavorable" roles of domestic and non-domestic animals on airway sensitization processes and on the type/severity of the clinical symptoms induced by their exposure. We pe…
View article: Climate change and allergic diseases: A scoping review
Climate change and allergic diseases: A scoping review Open
Introduction Increased greenhouse gas emissions since the industrial age have led to higher global temperatures and frequency and severity of climate events, such as heat waves, wildfires, floods, and storms. These changes are adversely af…
View article: Concurrent validity, cut‐offs and ability to change of patient‐reported outcome measures for rhinitis and asthma in MASK‐air<sup>®</sup>
Concurrent validity, cut‐offs and ability to change of patient‐reported outcome measures for rhinitis and asthma in MASK‐air<sup>®</sup> Open
Patient‐reported outcome measures (PROMs) are used to assess a patient's health status at a particular point in time. They are essential in the development of person‐centred care. This paper reviews studies performed on PROMs for assessing…
View article: Co-sensitizations to Gibberellin Regulated Proteins (GRPs) in Italy: results of a polycentric study
Co-sensitizations to Gibberellin Regulated Proteins (GRPs) in Italy: results of a polycentric study Open
Background. Gibberellin Regulated Proteins (GRPs) are small glycoproteins that induce allergy to various types of fruit. This study aimed to evaluate co-sensitization to cypress pollen and other molecules responsible for fruit aller…
View article: <scp>IgE</scp> Antibody Associations With Allergic Disease Phenotypes Using <scp>ISAC</scp> and <scp>ALEX</scp> Assays
<span>IgE</span> Antibody Associations With Allergic Disease Phenotypes Using <span>ISAC</span> and <span>ALEX</span> Assays Open
Over the past two decades, molecular allergen research has significantly advanced allergy diagnostics [1]. This progress has deepened our understanding of IgE-mediated responses, establishing clear links between specific allergens and clin…
View article: Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study
Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study Open
Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their associati…
View article: The impact of exposure to tobacco smoke and e‐cigarettes on asthma‐related outcomes: Systematic review informing the EAACI guidelines on environmental science for allergic diseases and asthma
The impact of exposure to tobacco smoke and e‐cigarettes on asthma‐related outcomes: Systematic review informing the EAACI guidelines on environmental science for allergic diseases and asthma Open
To inform the clinical practice guidelines' recommendations developed by the European Academy of Allergy and Clinical Immunology systematic reviews (SR) assessed using GRADE on the impact of environmental tobacco smoke (ETS) and active smo…
View article: Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation
Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation Open
Global warming and climate change have increased the pollen burden and the frequency and intensity of wildfires, sand and dust storms, thunderstorms, and heatwaves—with concomitant increases in air pollution, heat stress, and flooding. The…
View article: Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study
Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study Open
View article: The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
The impact of indoor pollution on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma Open
Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new‐onset asthma (incidence) and (ii) adverse asthma‐related outcomes (impact). MEDLIN…
View article: Investigating Sensitization to Novel Foods: A Real-Life Prevalence Study of IgE-Mediated Reactivity to Cricket, Locust, and Mealworm in Insect Food-Naïve Allergic Individuals
Investigating Sensitization to Novel Foods: A Real-Life Prevalence Study of IgE-Mediated Reactivity to Cricket, Locust, and Mealworm in Insect Food-Naïve Allergic Individuals Open
Background: With the global population on the rise, edible insects are considered a potential solution to food security, although concerns about risks such as anaphylaxis have been expressed. Methods: We tested 2014 participants using the …
View article: Why is Pet (cat/dog) allergen immunotherapy (AIT) such a controversial topic? Current perspectives and future directions
Why is Pet (cat/dog) allergen immunotherapy (AIT) such a controversial topic? Current perspectives and future directions Open
Dogs and cats are the most common pets worldwide. In Italy, the prevalence of allergic sensitization to cats and dogs is 16% and 9% respectively. The limited standardization of allergenic extracts, especially for dogs, emphasizes the impor…
View article: The impact of outdoor pollution and extreme temperatures on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
The impact of outdoor pollution and extreme temperatures on asthma‐related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma Open
Air pollution is one of the biggest environmental threats for asthma. Its impact is augmented by climate change. To inform the recommendations of the EAACI Guidelines on the environmental science for allergic diseases and asthma, a systema…
View article: Mollusk allergy in shrimp-allergic patients: still a complex diagnosis. An Italian multicenter study
Mollusk allergy in shrimp-allergic patients: still a complex diagnosis. An Italian multicenter study Open
Introduction | Shellfish allergy is an important cause of food allergies worldwide. Both in vivo and in vitro diagnostics failure nowadays is caused by the poor quality of the extracts associated with the scarce availability of allergenic …
View article: Phl p 5 levels more strongly associated than grass pollen counts with allergic respiratory health
Phl p 5 levels more strongly associated than grass pollen counts with allergic respiratory health Open
View article: IgE-mediated reactivity to non-specific lipid transfer protein (nsLTP): clinical implications and management ‒ a consensus document of the Association of Italian Territorial and Hospital Allergists and Immunologists (AAIITO)
IgE-mediated reactivity to non-specific lipid transfer protein (nsLTP): clinical implications and management ‒ a consensus document of the Association of Italian Territorial and Hospital Allergists and Immunologists (AAIITO) Open
The primary cause of adult-onset food allergy in Mediterranean countries is IgE-mediated reactivity to non-specific Lipid Transfer Protein (nsLTP), with a prevalence of 9.5% in Italy. nsLTP is heat- and pepsin-stable due to its 3D structur…
View article: Optimization of the diagnosis and characterization of gibberellin-regulated protein sensitization
Optimization of the diagnosis and characterization of gibberellin-regulated protein sensitization Open
View article: Clinical severity of LTP syndrome is associated with an expanded IgE repertoire, FDEIA, FDHIH, and LTP mono reactivity
Clinical severity of LTP syndrome is associated with an expanded IgE repertoire, FDEIA, FDHIH, and LTP mono reactivity Open
Background. Lipid transfer proteins (LTP) allergy is often a challenge for clinicians. We evaluated a multiplex diagnostic approach with diverse cofactors to stratify LTP syndrome risk. Methods. Of the 1,831 participants scre…
View article: Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study
Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study Open
View article: Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study
Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study Open
In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.
View article: Severe asthma: follow-up after one year from the Italian Registry on Severe Asthma (IRSA)
Severe asthma: follow-up after one year from the Italian Registry on Severe Asthma (IRSA) Open
Background. Asthma affects millions of people worldwide, with a subgroup suffering from severe asthma (SA). Biologics have revolutionized SA treatment, but challenges remain in managing different patient traits. This study analyzed …