Lorenzo Giordani
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View article: Across the space: applications of spatial transcriptomic technology in healthy and diseased muscle
Across the space: applications of spatial transcriptomic technology in healthy and diseased muscle Open
In recent years, spatial transcriptomics (ST) has emerged as a groundbreaking technology with the potential to transform and accelerate our understanding of cellular crosstalk. While single-cell approaches have uncovered an unexpected leve…
View article: GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD
GDF5 modulation of MuSC pool as a potential therapeutic benefit for DMD Open
Duchenne muscular dystrophy (DMD) is a fatal disease caused by dystrophin deficiency, leading to degeneration of the entire musculature. To improve muscle pathophysiology and gene therapy for DMD, we investigated the potential of growth di…
View article: Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation
Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation Open
View article: Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS
Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS Open
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease causing progressive paralysis due to motor neuron degeneration with no curative therapy despite extensive biomedical research. One of the primary targets of ALS is sk…
View article: VIB Hackathon on spatial omics tools and methods
VIB Hackathon on spatial omics tools and methods Open
During a three-day hackathon, work was performed on various topics within the field of spatial omics data analysis. The topics were organized in five workgroups and included benchmarking, pipelines, spatial transcriptomics, spatial proteom…
View article: Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation
Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation Open
View article: Author Correction: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis
Author Correction: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis Open
View article: Injury-experienced satellite cells retain long-term enhanced regenerative capacity
Injury-experienced satellite cells retain long-term enhanced regenerative capacity Open
View article: Editorial: Cellular heterogeneity in physiological and pathological myogenesis
Editorial: Cellular heterogeneity in physiological and pathological myogenesis Open
EDITORIAL article Front. Cell Dev. Biol., 15 June 2023Sec. Stem Cell Research Volume 11 - 2023 | https://doi.org/10.3389/fcell.2023.1235520
View article: Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation
Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation Open
Modulations in chromatin structure orchestrate gene expression and direct stem cell fate. More specifically, the histone 3 lysine 9 Methyltransferase Setdb1 controls transcriptional repression to regulate pluripotency and self-renewal. Whi…
View article: Injury-experienced satellite cells retain long-term enhanced regenerative capacity
Injury-experienced satellite cells retain long-term enhanced regenerative capacity Open
Background Inflammatory memory or trained immunity is a recently described process in immune and non-immune tissue resident cells, whereby previous exposure to inflammation mediators leads to a faster and stronger responses upon secondary …
View article: Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle Open
Spatial Transcriptomics Data of murine skeletal muscle undergoing reversible nerve injury. Accompanying the manuscript, D'Ercole et al. "Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skele…
View article: Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle Open
View article: Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle Open
SUMMARY Striated muscle is a highly organized structure composed by well-defined anatomical domains with integrated but distinct assignments. So far, the lack of a direct correlation between tissue architecture and gene expression has limi…
View article: A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis
A negative feedback loop between fibroadipogenic progenitors and muscle fibres involving endothelin promotes human muscle fibrosis Open
Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle fibrosis occurs in response to t…
View article: Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity
Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity Open
Aging-associated muscle wasting and impaired regeneration are caused by deficiencies in muscle stem cell (MuSC) number and function. We postulated that aged MuSCs are intrinsically impaired in their responsiveness to omnipresent mechanical…
View article: Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle
Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skeletal muscle Open
Spatial Transcriptomics Data of murine skeletal muscle undergoing reversible nerve injury. Accompanying the manuscript, D'Ercole et al. "Spatially resolved transcriptomics reveals innervation-responsive functional clusters in skele…
View article: Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche
Myofiber stretch induces tensile and shear deformation of muscle stem cells in their native niche Open
View article: Activation of skeletal muscle–resident glial cells upon nerve injury
Activation of skeletal muscle–resident glial cells upon nerve injury Open
Here, we report on the identification of Itga7-expressing muscle-resident glial cells activated by loss of neuromuscular junction (NMJ) integrity. Gene expression analysis at the bulk and single-cell level revealed that these cells are dis…
View article: TGFβ signaling curbs cell fusion and muscle regeneration
TGFβ signaling curbs cell fusion and muscle regeneration Open
View article: GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism
GREM1 is epigenetically reprogrammed in muscle cells after exercise training and controls myogenesis and metabolism Open
Exercise training improves skeletal muscle function, notably through tissue regeneration by muscle stem cells. Here, we hypothesized that exercise training reprograms the epigenome of muscle cell, which could account for better muscle func…
View article: 240th ENMC workshop: The involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25–27 January 2019, Hoofddorp, The Netherlands
240th ENMC workshop: The involvement of skeletal muscle stem cells in the pathology of muscular dystrophies 25–27 January 2019, Hoofddorp, The Netherlands Open
View article: La signalisation TGFβ contrôle la fusion cellulaire et la régénération musculaire
La signalisation TGFβ contrôle la fusion cellulaire et la régénération musculaire Open
View article: High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations
High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle-Resident Cell Populations Open
View article: TGFβ signaling curbs cell fusion and muscle regeneration
TGFβ signaling curbs cell fusion and muscle regeneration Open
Summary Fusion of muscle progenitor cells is necessary for skeletal muscle development and repair. Cell fusion is a multistep process involving cell migration, adhesion, membrane remodeling and actin-nucleation pathways to generate multinu…
View article: Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy
Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy Open
Fibro-adipogenic progenitors (FAPs) are currently defined by their anatomical position, expression of non-specific membrane-associated proteins, and ability to adopt multiple lineages in vitro. Gene expression analysis at single-cell level…
View article: Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis
Denervation-activated STAT3–IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis Open
View article: L’analyse par cytométrie de masse des muscles âgés et dystrophiques permet d’identifier des nouvelles populations distinctes des cellules satellites
L’analyse par cytométrie de masse des muscles âgés et dystrophiques permet d’identifier des nouvelles populations distinctes des cellules satellites Open
View article: High-dimensional single-cell cartography reveals novel skeletal muscle resident cell populations
High-dimensional single-cell cartography reveals novel skeletal muscle resident cell populations Open
Adult tissue repair and regeneration require the activation of resident stem/progenitor cells that can self-renew and generate differentiated progeny. The regenerative capacity of skeletal muscle relies on muscle satellite cells (MuSCs) an…
View article: High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle Resident Cell Populations
High-Dimensional Single-Cell Cartography Reveals Novel Skeletal Muscle Resident Cell Populations Open