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View article: NOVEL IONS IN HADRONTHERAPY: AN IN-VITRO AND IN-SILICO STUDY USING A CLINICAL HELIUM BEAM FOR EVALUATION OF ITS THERAPEUTIC POTENTIAL
NOVEL IONS IN HADRONTHERAPY: AN IN-VITRO AND IN-SILICO STUDY USING A CLINICAL HELIUM BEAM FOR EVALUATION OF ITS THERAPEUTIC POTENTIAL Open
View article: CELLULAR IRRADIATION WITH 583 KEV PROTONS FOR BNCT: A RADIOBIOLOGICAL STUDY TOWARDS ACCURATE ESTIMATION OF THE NITROGEN DOSE CONTRIBUTION
CELLULAR IRRADIATION WITH 583 KEV PROTONS FOR BNCT: A RADIOBIOLOGICAL STUDY TOWARDS ACCURATE ESTIMATION OF THE NITROGEN DOSE CONTRIBUTION Open
View article: Microdosimetric characterization of a clinical helium beam using a MicroPlus-Bridge detector and a diamond detector for RBE assessment
Microdosimetric characterization of a clinical helium beam using a MicroPlus-Bridge detector and a diamond detector for RBE assessment Open
Objective . This study aims to perform a comprehensive microdosimetric characterization of a clinical helium ion beam at the Heidelberg ion-beam Therapy center, assessing radiation quality along a spread-out Bragg peak (SOBP) and providing…
View article: Cellular irradiation with 583 keV protons at the CIRCE tandem accelerator: adosimetric and radiobiological investigation for BNCT applications
Cellular irradiation with 583 keV protons at the CIRCE tandem accelerator: adosimetric and radiobiological investigation for BNCT applications Open
Boron Neutron Capture Therapy (BNCT) exploits the 10 B(n, α ) 7 Li reaction to deliver localized high-LET radiation to tumour cells enriched with 10 B-labelled drugs. However, other neutron-induced reactions, including 14 N(n,p) 14 C, also…
View article: From ultrafast laser-generated radiation to clinical impact: a roadmap for radiobiology and cancer research at the extreme light infrastructure (ELI)
From ultrafast laser-generated radiation to clinical impact: a roadmap for radiobiology and cancer research at the extreme light infrastructure (ELI) Open
View article: ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons
ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons Open
The ELIMAIA-ELIMED beamline, powered by the L3 HAPLS petawatt laser, enables the irradiation of biological samples with intermediate-energy laser-driven protons (LDP) in a multi-shot regime. In the pilot radiobiological experiment, protons…
View article: A GATE Monte Carlo study on ICRP110 phantoms for BNCT dosimetry evaluation
A GATE Monte Carlo study on ICRP110 phantoms for BNCT dosimetry evaluation Open
Boron Neutron Capture Therapy (BNCT) is attracting renewed attention due to advancements in compact proton accelerators for the production of neutron beams, and new BNCT facilities are being planned all around the world. A key aspect in BN…
View article: Discrimination of Different Human Cell Lines by Using FT-IR Spectra Spectroscopy
Discrimination of Different Human Cell Lines by Using FT-IR Spectra Spectroscopy Open
Fourier transform infrared (FT-IR) spectroscopy is a powerful analytical technique used to obtain molecular fingerprints of various biological samples. This study aims to compare the FT-IR spectra of three distinct cell lines, SH-SY5Y (neu…
View article: First Dosimetric and Biological Verification for Spot-Scanning Hadron Arc Radiation Therapy With Carbon Ions
First Dosimetric and Biological Verification for Spot-Scanning Hadron Arc Radiation Therapy With Carbon Ions Open
The first proof-of-principle of carbon ions SHArc delivery was performed, and experimental evidence suggests this novel modality as an attractive approach for treating hypoxic tumors.
View article: FIRST BIOPHYSICAL VERIFICATION FOR SPOT-SCANNING HADRON ARC RADIOTHERAPY WITH HELIUM AND CARBON IONS
FIRST BIOPHYSICAL VERIFICATION FOR SPOT-SCANNING HADRON ARC RADIOTHERAPY WITH HELIUM AND CARBON IONS Open
View article: RadPhysBio: A Radiobiological Database for the Prediction of Cell Survival upon Exposure to Ionizing Radiation
RadPhysBio: A Radiobiological Database for the Prediction of Cell Survival upon Exposure to Ionizing Radiation Open
Based on the need for radiobiological databases, in this work, we mined experimental ionizing radiation data of human cells treated with X-rays, γ-rays, carbon ions, protons and α-particles, by manually searching the relevant literature in…
View article: Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice
Impact on the Transcriptome of Proton Beam Irradiation Targeted at Healthy Cardiac Tissue of Mice Open
Proton beam therapy is considered a step forward with respect to electromagnetic radiation, thanks to the reduction in the dose delivered. Among unwanted effects to healthy tissue, cardiovascular complications are a known long-term radioth…
View article: Fluorescence In Situ Hybridization-Based Chromosome Aberration Analysis Unveils the Mechanistic Basis for Boron-Neutron Capture Therapy’s Radiobiological Effectiveness
Fluorescence In Situ Hybridization-Based Chromosome Aberration Analysis Unveils the Mechanistic Basis for Boron-Neutron Capture Therapy’s Radiobiological Effectiveness Open
Boron-Neutron Capture Therapy (BNCT) is a tumor-selective radiotherapy, based on the nuclear capture reaction 10B(n,α)7Li producing short range α-particles and recoiling 7Li nuclei exclusively confined to boron-enriched cancer cells. These…
View article: Seed Priming by Low-Dose Radiation Improves Growth of Lactuca sativa and Valerianella locusta
Seed Priming by Low-Dose Radiation Improves Growth of Lactuca sativa and Valerianella locusta Open
Valerian salad and lettuce are edible species that are easy to grow rapidly, and have traits useful for commercial purposes. The consumption of these species is increasing worldwide for their nutritional properties. Seed germination and se…
View article: A Comparison between Different Acquisition Modes for FT-IR Spectra Collection from Human Cell Lipid Extracts
A Comparison between Different Acquisition Modes for FT-IR Spectra Collection from Human Cell Lipid Extracts Open
Lipids are organic compounds that contribute to numerous cellular functions. Fourier Transform Infrared spectroscopy can be particularly useful in investigating the biochemical features of the lipid content of cells and their changes induc…
View article: A Sphingolipidomic Profiling Approach for Comparing X-ray-Exposed and Unexposed HepG2 Cells
A Sphingolipidomic Profiling Approach for Comparing X-ray-Exposed and Unexposed HepG2 Cells Open
An analytical method based on tandem mass spectrometry-shotgun is presently proposed to obtain sphingolipidomic profiles useful for the characterization of lipid extract from X-ray-exposed and unexposed hepatocellular carcinoma cells (HepG…
View article: Evaluation of morpho-physiological responses and genotoxicity in <i>Eruca sativa</i> (Mill.) grown in hydroponics from seeds exposed to X-rays
Evaluation of morpho-physiological responses and genotoxicity in <i>Eruca sativa</i> (Mill.) grown in hydroponics from seeds exposed to X-rays Open
Due to its potential applications in cultivated plants, ionizing radiation (IR) and its effect on organisms is increasingly studied. Here we measured the effects of ionizing radiation on Eruca sativa by analyzing plants from irradiated see…
View article: Data from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Data from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. A…
View article: Data from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Data from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ovarian cancers. BRCA1 functions to maintain genomic stability through critical roles in DNA repair, cell-cycle arrest, and transcriptional control. A…
View article: Supplementary Methods from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Supplementary Methods from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
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View article: Supplementary Figure Legends from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Supplementary Figure Legends from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
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View article: Supplementary Figure Legends from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Supplementary Figure Legends from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
PDF file - 75K
View article: Supplementary Methods from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Supplementary Methods from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
PDF file - 124K
View article: Supplementary Figures 1 - 6 from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Supplementary Figures 1 - 6 from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
PDF file - 2823K, Supplementary Figure 1. Estrogen metabolites cause DNA double strand breaks in S- phase cells. Supplementary Figure 2. BRCA1 supresses estrogen metabolite mediated DSBs and is required for their repair. Supplementary Figu…
View article: Supplementary Figures 1 - 6 from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability
Supplementary Figures 1 - 6 from BRCA1 Deficiency Exacerbates Estrogen-Induced DNA Damage and Genomic Instability Open
PDF file - 2823K, Supplementary Figure 1. Estrogen metabolites cause DNA double strand breaks in S- phase cells. Supplementary Figure 2. BRCA1 supresses estrogen metabolite mediated DSBs and is required for their repair. Supplementary Figu…
View article: An FTIR Spectroscopy Investigation on Different Methods of Lipid Extraction from HepG2 Cells
An FTIR Spectroscopy Investigation on Different Methods of Lipid Extraction from HepG2 Cells Open
Fourier transform infrared (FTIR) spectroscopy is a non-invasive technique that is largely used for studying lipidomics. Lipids are a primary class of biological molecules that play numerous vital roles in various processes. In the present…
View article: Differential Radiomodulating Action of Olea europaea L. cv. Caiazzana Leaf Extract on Human Normal and Cancer Cells: A Joint Chemical and Radiobiological Approach
Differential Radiomodulating Action of Olea europaea L. cv. Caiazzana Leaf Extract on Human Normal and Cancer Cells: A Joint Chemical and Radiobiological Approach Open
The identification of a natural compound with selectively differential radiomodulating activity would arguably represent a valuable asset in the striving quest for widening the therapeutic window in cancer radiotherapy (RT). To this end, w…
View article: Evaluation of Proton-Induced Biomolecular Changes in MCF-10A Breast Cells by Means of FT-IR Microspectroscopy
Evaluation of Proton-Induced Biomolecular Changes in MCF-10A Breast Cells by Means of FT-IR Microspectroscopy Open
Radiotherapy (RT) with accelerated beams of charged particles (protons and carbon ions), also known as hadrontherapy, is a treatment modality that is increasingly being adopted thanks to the several benefits that it grants compared to conv…
View article: A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach
A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach Open
Protontherapy (PT) is a fast-growing cancer therapy modality thanks to much-improved normal tissue sparing granted by the charged particles’ inverted dose-depth profile. Protons, however, exhibit a low biological effectiveness at clinicall…
View article: Editorial: Ionizing Radiation and Human Health: A Multifaceted Relationship
Editorial: Ionizing Radiation and Human Health: A Multifaceted Relationship Open
(https://doi.org/10.3389/fonc.2021.682647) propose an approach conceptually similar to 3 that of BNCT, termed proton boron capture therapy (PBCT) as a strategy to make proton 4 therapy amenable towards radiotherapy-resilient tumors, toward…