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View article: Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis
Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis Open
Background This Consensus Workshop dealt with diagnostic methodologies in the context of surveillance, screening, assessment of stage and grade, prognosis, monitoring and prediction of periodontal status. Several elements provided the impe…
View article: Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier
Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier Open
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a critical regulator of neutrophil function at the oral mucosal barrier. We demonstrate that commensal microbiota tri…
View article: Editorial: The impact of inflammation on the oral microbiome
Editorial: The impact of inflammation on the oral microbiome Open
EDITORIAL article Front. Oral. Health, 22 September 2023Sec. Oral Infections and Microbes Volume 4 - 2023 | https://doi.org/10.3389/froh.2023.1293228
View article: Increased STAT3 Activation in Periodontitis Drives Inflammatory Bone Loss
Increased STAT3 Activation in Periodontitis Drives Inflammatory Bone Loss Open
Periodontitis is one of the most prevalent human inflammatory diseases. It is characterized by periodontal tissue destruction, progressively driven by the host response. In this regard, cytokines associated with tissue destruction, such as…
View article: Cover Image, Volume 37, Issue 5
Cover Image, Volume 37, Issue 5 Open
The cover image is based on the Original Article A reappraisal of microbiome dysbiosis during experimental periodontitis by Marion Arce et al., https://doi.org/10.1111/omi.12382.
View article: Editorial: Oral Microbiome and Inflammation Connection to Systemic Health
Editorial: Oral Microbiome and Inflammation Connection to Systemic Health Open
ANID/Chilean National Fund for Scientific and Technologic Development (FONDECYT)\t11180505\t
\nR01DE025037\t
\nR01DE027374\t
\nUnited States Department of Health & Human Services
\nNational Institutes of Health (NIH) - USA
\nNIH National I…
View article: A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen
A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen Open
Recent studies describe in detail the shifts in composition of human-associated polymicrobial communities from health to disease. However, the specific processes that drive the colonization and overgrowth of pathogens within these communit…
View article: A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen
A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen Open
Recent studies describe in detail the shifts in composition of human-associated polymicrobial communities from health to disease. However, the specific processes that drive the colonization and overgrowth of pathogens within these communit…
View article: Establishment and Stability of the Murine Oral Microbiome
Establishment and Stability of the Murine Oral Microbiome Open
Commensal microbiomes exert critical functions at barrier sites. In particular, establishment of the commensal microbiome after birth dictates immune functionality and tissue homeostasis at mucosal surfaces. To investigate the establishmen…
View article: Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis Open
A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites of disease initiation. The common occurrence of periodontal dysbiosis in RA…
View article: Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome
Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome Open
The importance of the microbiome in health and its disruption in disease is continuing to be elucidated. However, the multitude of host and environmental factors that influence the microbiome are still largely unknown. Here, we examined UD…
View article: Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis
Human defects in STAT3 promote oral mucosal fungal and bacterial dysbiosis Open
Studies in patients with genetic defects can provide unique insights regarding the role of specific genes and pathways in humans. Patients with defects in the Th17/IL-17 axis, such as patients harboring loss-of-function STAT3 mutations (au…
View article: <i>Aggregatibacter actinomycetemcomitans</i> –induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis
<i>Aggregatibacter actinomycetemcomitans</i> –induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis Open
Aggregatibacter actinomycetemcomitans generates citrullinated autoantigens involved in rheumatoid arthritis through its pore-forming toxin leukotoxin A.
View article: Colitis susceptibility in p47 phox−/− mice is mediated by the microbiome
Colitis susceptibility in p47 phox−/− mice is mediated by the microbiome Open
Our findings suggest that the microbiome signature established at birth may play a bigger role than phagocyte-derived reactive oxygen species in mediating colitis susceptibility in CGD mice. These data further support bacteria-related dise…
View article: Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network Open
Immune cell networks in tissues play a vital role in mediating local immunity and maintaining tissue homeostasis, yet little is known of the resident immune cell populations in the oral mucosa and gingiva. We have established a technique f…
View article: Host response mechanisms in periodontal diseases
Host response mechanisms in periodontal diseases Open
Periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including Porphyromonas gingivalis, Aggregatibacter actinomy…
View article: Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology
Subgingival Microbial Communities in Leukocyte Adhesion Deficiency and Their Relationship with Local Immunopathology Open
Leukocyte Adhesion Deficiency I (LAD-I) is a primary immunodeficiency caused by single gene mutations in the CD18 subunit of β2 integrins which result in defective transmigration of neutrophils into the tissues. Affected patients suffer fr…