Loretta Dorstyn
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View article: Understanding Developmental Cell Death Using Drosophila as a Model System
Understanding Developmental Cell Death Using Drosophila as a Model System Open
Cell death plays an essential function in organismal development, wellbeing, and ageing. Many types of cell deaths have been described in the past 30 years. Among these, apoptosis remains the most conserved type of cell death in metazoans …
View article: Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
Phosphorylation by Aurora B kinase regulates caspase-2 activity and function Open
Mitotic catastrophe (MC) is an important oncosuppressive mechanism that serves to eliminate cells that become polyploid or aneuploidy due to aberrant mitosis. Previous studies have demonstrated that the activation and catalytic function of…
View article: Caspase-2-mediated cell death is required for deleting aneuploid cells
Caspase-2-mediated cell death is required for deleting aneuploid cells Open
Caspase-2, one of the most evolutionarily conserved of the caspase family, has been implicated in maintenance of chromosomal stability and tumour suppression. Caspase-2 deficient (Casp2-/-) mice develop normally but show premature ageing-r…
View article: Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice Open
The apoptotic cysteine protease caspase-2 has been shown to suppress tumourigenesis in mice and its reduced expression correlates with poor prognosis in some human malignancies. Caspase-2-deficient mice develop normally but show ageing-rel…
View article: Fat, sex and caspase-2
Fat, sex and caspase-2 Open
Caspases are a family of cysteine-dependent aspartate-specific proteolytic enzymes, known best for their roles in cell death and immune responses.1 Caspase-2, one of the first members of this family to be identified, is the most evolutiona…