Lori A. Flood
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View article: Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling
Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling Open
The molecular basis of selectivity in G-protein receptor coupling has been explored by comparing the abilities of G-protein heterotrimers containing chimeric Galpha subunits, comprised of various regions of Gi1alpha, Gtalpha, and Gqalpha, …
View article: Agonist Regulation of D2 Dopamine Receptor/G Protein Interaction
Agonist Regulation of D2 Dopamine Receptor/G Protein Interaction Open
The D(2) dopamine receptor has been expressed in Sf21 insect cells together with the G proteins G(o) and G(i2), using the baculovirus system. Expression levels of receptor and G protein (alpha, beta, and gamma subunits) in the two preparat…
View article: Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions
Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions Open
The recognition between G protein and cognate receptor plays a key role in specific cellular responses to environmental stimuli. Here we explore specificity in receptor-G protein coupling by taking advantage of the ability of the 5-hydroxy…