Lori Hand
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View article: Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients
Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients Open
Importance Pantoprazole reduces clinically important upper gastrointestinal bleeding in critically ill patients. However, the cost-effectiveness of this strategy is unclear. Objective To assess the cost-effectiveness of daily intravenous p…
View article: Coenrolment in a Stress Ulcer Prophylaxis Trial: Protocol for a Substudy of Characteristics and Consequences
Coenrolment in a Stress Ulcer Prophylaxis Trial: Protocol for a Substudy of Characteristics and Consequences Open
Background Coenrolment is defined as the enrolment of an individual patient into more than one study. This protocol describes a study of coenrolment nested in a randomized, blinded, parallel-group trial of stress ulcer prophylaxis comparin…
View article: Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria
Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria Open
Importance Accurate and timely confirmation of death by neurologic criteria (DNC) is essential for clinical decision-making and organ-donation processes, yet currently available ancillary tests have suboptimal diagnostic performance or lim…
View article: Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study
Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study Open
PROSPECT (Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial): NCT02462590.
View article: Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit
Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit Open
In adults with sepsis receiving vasopressor therapy in the ICU, those who received intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. (Funded by the Lotte and John H…
View article: Additional file 2: of Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study
Additional file 2: of Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study Open
Table S6. Compositional differences between respiratory specimens of patients deceased versus discharged alive from the hospital. (XLS 68 kb)
View article: Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors
Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors Open
Introduction Research on the management of deceased organ donors aims to improve the number and quality of transplants and recipient outcomes. In Canada, this research is challenged by regionalisation of donation services within provinces …
View article: Contemporary Ventilation Strategies And Adjunctive Therapies For Acute Respiratory Distress Syndrome (Ards)
Contemporary Ventilation Strategies And Adjunctive Therapies For Acute Respiratory Distress Syndrome (Ards) Open
Over the past 5 years, several interventions have been shown in randomized clinical trials (RCTs) to reduce mortality in patients with ARDS. The current use of these interventions in clinical practice, along with those of unproven benefit,…